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Том 6 №1 2004 год - Нефрология и диализ

Роль оксидативного стресса в патологии сердечно-сосудистой системы у больных с заболеваниями почек (Сообщение I. Патофизиология оксидативного стресса)


Саенко Ю.В. Шутов А.М.

Аннотация: Оксидативный стресс является составной частью патогенеза многих заболеваний. Причиной возникновения окислительного стресса является увеличение продукции свободных радикалов и (или) снижение эффективности антиоксидантных систем организма. В обзоре рассмотрены основные типы свободно-радикальных молекул и радикальных реакций. Освещены основные источники возникновения свободно-радикальных молекул в клетках и представлены механизмы свободно-радикального повреждения клеток и тканей. Особое внимание уделено внеклеточным и внутриклеточным физиологическим антиоксидантным системам. Дана характеристика основных типов антиоксидантных молекул и ферментов, а также их роли в поддержании внутриклеточного окислительно-восстановительного потенциала. Первое сообщение касается патофизиологии оксидативного стресса, второе будет посвящено клиническим аспектам проблемы.

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Ключевые слова: заболевания почек, оксидативный стресс, сердечно-сосудистая патология, хроническая почечная недостаточность

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