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Том 6 №3 2004 год - Нефрология и диализ

Механизмы нефросклефоза; фармакологическая ингибиция внутрипочечной ренин-ангиотензиновой системы как основа нефропротективной стратегии при хронических заболеваниях нативных почек и почечного трансплантата (Обзор литературы)


Томилина Н.А. Багдасарян А.Р.

Аннотация: Вопрос о механизмах прогрессирования хронических заболеваний почек является одним из центральных в современной нефрологии. На протяжении последних двух с половиной десятилетий его изучение ознаменовалось рядом открытий, которые позволили сформулировать современную концепцию патогенеза нефросклероза. Стало очевидным, в частности, что прогрессирование любых хронических заболеваний почек, независимо от их природы, определяется действием совокупности одних и тех же клеточных и молекулярных механизмов, которые с биологической точки зрения представляют собой комплекс процессов, направленных на репарацию тканей организма в ответ на их повреждение [101, 102].

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Ключевые слова: ингибиторы АПФ, нефропротекция, нативные почки и трансплантат

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