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Том 12 №3 2010 год - Нефрология и диализ

Катастрофический антифосфолипидный синдром у молодой больной системной красной волчанкой


Козловская Н.Л. Томилина Н.А. Столяревич Е.С. Бирюкова Л.С. Скрябина И.А. Кальянова Е.В. Варясин В.В. Жукова М.Е.

Аннотация: В статье приводятся сведения о КАФС, в том числе основные концепции патогенеза, клинические проявления, морфологические особенности, подходы к диагностике и лечению, подчеркиваются его отличия от классических вариантов АФС – первичного и вторичного при СКВ. Обзор иллюстрирован клиническим наблюдением больной КАФС, развившимся как основное проявление СКВ. На примере представленного случая разбираются некоторые аспекты дифференциальной диагностики КАФС с другими микроангиопатическими синдромами – ГУС/ТТП и ДВС.

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Ключевые слова: катастрофический антифосфолипидный синдром (КАФС), системная красная волчанка (СКВ), тромботическая тромбоцитопеническая пурпура, тромботическая микроангиопатия, ДВС-синдром, полиорганная недостаточность, catastrophic antiphospholipid syndrome (CAPS), systemic lupus erythematosus (SLE), thrombotic thrombocytopenic purpura, trombotic microangiopathies, disseminated intravascular coagulation syndrome

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