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Том 4 №3 2002 год - Нефрология и диализ

Цитокины и адгезивные молекулы в патогенезе хронического гломерулонефрита (Обзор литературы, часть I)


Вашурина Т.В. Сергеева Т.В.

Аннотация: За последние десять лет, благодаря интенсивному развитию иммунологии, клеточной и молекулярной биологии, был достигнут большой прогресс в изучении и понимании патогенеза гломерулонефрита (ГН). Патогенез гломерулонефрита условно может быть разделен на две стадии: иммунную и воспалительную [152]. Первая стадия включает различные звенья иммунного ответа на чужеродные или собственные антигены (АГ) и заканчивается образованием иммунных комплексов (ИК), нефритогенных лимфоцитов или аутоантител [152].

Для цитирования: Вашурина Т.В., Сергеева Т.В. Цитокины и адгезивные молекулы в патогенезе хронического гломерулонефрита (Обзор литературы, часть I). Нефрология и диализ. 2002. 4(3):171-181. doi:


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Ключевые слова: хронический гломерулонефрит, цитокины, адгезивные молекулы

Список литературы:
  1. Богомазов С.Ю., Гладских О.П., Иванов А.А. и др. Цитокины и внеклеточный матрикс при экспериментальных гломерулопатиях. Арх. патологии 1997; 59; 6: 45-50.
  2. Кетлинский С.А., Калинина Н.М. Цитокины мононуклеарных фагоцитов в регуляции реакции воспаления и иммунитета. Иммунология 1995; 3: 30-44.
  3. Пальцев М.А., Иванов А.А. Возможные механизмы развития гломерулосклероза при нефропатиях различного генеза. Арх. патологии 1994; 56; 6: 13-16.
  4. Пальцев М.А., Иванов А.А. Межклеточные взаимодействия. М.: Медицина, 1995; 26.
  5. Сергеева Т.В., Вознесенская Т.С., Клочков С.А. Клинические проявления мезангиопролиферативного гломерулонефрита у детей. Рос. педиатр. журнал 1999; 1: 7-10.
  6. Сергеева Т.В., Цыгин А.Н., Чумакова О.А. и др. Факторы прогрессирования гломерулонефрита у детей. Рос. педиатр. журнал 2000; 5: 20-22.
  7. Соловьев А.А. Клинико-иммунологические и морфологические особенности ХГН у детей: Автореф. дисс. … канд. мед. наук. 1998; 45.
  8. Студеникин М.Я., Наумова В.И., Гнатюк А.И. и др. Классификация гломерулонефрита у детей. Педиатрия 1977; 2: 3-8.
  9. Фрейдлин И.С. Ключевая позиция макрофагов в цитокиновой регуляторной сети. Иммунология 1995; 3: 44-48.
  10. Хиллис Г.С., Маклеод А.М. Роль интегриновых рецепторов адгезии при заболеваниях почек. Нефрология 1997; 1; 1: 11-26.
  11. Цыгин А.Н. Патогенетические основы первичного нефротического синдрома и лечения его стероидрезистентных вариантов у детей: Автореф. дисс. … д-ра мед. наук. 1996; 42.
  12. Цыгин А.Н., Сенцова Т.Б., Сергеева Т.В. и др. Уровень растворимого рецептора к интерлейкину-2 и фактора некроза опухоли-α в сыворотке крови детей с нефротическим синдромом. Педиатрия 1997; 2: 53-56.
  13. Цыгин А.Н., Сергеева Т.В. Лечение гломерулонефрита у детей. Рус. мед. журнал 1998; 6; 9: 580-585.
  14. Шубич М.Г., Авдеева М.Г., Вакуленко А.Д. Адгезивные межклеточные взаимодействия. Арх. патологии 1997; 59; 6: 3-9.
  15. Ярилин А.А. Система цитокинов и принципы ее функционирования в норме и при патологии. Иммунология 1997; 5: 7-14.
  16. Akutsu Y. Study of correlation between urinary IL-6 level and mesangial lesion in childhood onset IgA nephropathy. Hokkaido Igaku Zasshi 1994; 69; 4: 686-696.
  17. Alexopoulos E., Apostolos K., Papadimitriou M. Increased glomerular and interstitial LFA-1 expression in proteinuric immunoglobulin A nephropathy. Am J Kidney Dis 1996; 27; 3: 327-333.
  18. Baba Y., Akagi H., Fukushima K. et al. Quantitative analysis of interleukin 6 (IL-6) in patients with IgA nephropathy after tonsillectomy. Auris Nasus Larynx 1999; 26; 2: 177-180.
  19. Bagga A., Vasudev A.S., Moudgil A., Srivastava R.N. Peripheral blood lymphocyte subsets in idiopathic nephrotic syndrome of childhood. Indian J Med Res 1996; 104: 292-295.
  20. Bai L.Q., Chen X.M., Mao J. Effects of methylprednisolone pulse therapy on TNF-alpha levels in chronic nephritis. Chung Hua Nei Ko Tsa Chih 1994; 33; 12: 827-829.
  21. Bakker W.W., Baller J.F.W., Luijk W.H.J. A kallikrein-like molecule and plasma vasoactivity in minimal change disease. Contrib Nephrol 1988; 67: 31-36.
  22. Ballardie F.W., Gordon M.T., Sharpe P.T. et al. Intrarenal cytokine mRNA expression and location in normal and IgA nephropathy tissue: TGF-alpha, TGF-beta, IGF-1, IL-4 and IL-6. Nephrol Dial Transplant 1994; 9; 11: 1545-1552.
  23. Baraldi A., Zambruno G., Furci L. et al. Beta 1 and beta 3 integrin upregulation in rapidly progressive glomerulonephritis. Nephrol Dial Transplant 1995; 10; 7: 1155-1161.
  24. Baricos W.H., Cortez S.L., Deboisblanc M. et al. Transforming growth factor-beta is a potent inhibitor of extracellular matrix degradation by cultured human mesangial cells. J Am Soc Nephrol 1999; 10; 4: 790-795.
  25. Baskin B., Pettersson E., Rekola S. et al. Studies of the molecular basis of IgA production, subclass regulation and class-switch recombination in IgA nephropathy patients. Clin Exp Immunol 1996; 106; 3: 509-517.
  26. Battistini B., Chailler P., D’Orleans-Juste P. et al. Growth regulatory properties of endothelins. Peptides 1993; 14: 385-399.
  27. Baud L., Fouqueray B., Belloqo A. Switching off renal inflammation by anti-inflammatory mediators: The facts, the promise and the hope. Kidney Int 1998; 53: 1118-1126.
  28. Bock G.H., Ongkingco J.R., Patterson L.T., Ruley J. et al. Serum and urine soluble interleukin-2 receptor in idiopathic nephrotic syndrome. Pediatr Nephrol 1993; 7; 5: 523-528.
  29. Border W.A., Noble N.A., Yamamoto T. et al. Natural inhibitor of TGF-beta protects against scarring in experimental kidney disease. Nature 1992; 360: 361-364.
  30. Border W.A., Okuda S., Languino L.K. et al. Supression of experimental glomerulonephritis by antiserum against TGF-beta. Nature 1990; 346: 371-374.
  31. Border W.A., Okuda S., Ruoslahti E. et al. Transforming growth factor-beta regulates production of proteoglycans by mesangial cells. Kidney Int 1990; 37: 689-695.
  32. Boucher D., Gogusev J., Droz D. Expression of IL6 and TNF-alpha in normal and pathological kidney. C R Seances Soc Biol Fil 1993; 7; 4: 425-433.
  33. Bustos C., Gonzalez E., Mulley R. et al. Increase of tumor necrosis factor-alpha synthesis and gene expression in peripheral blood mononuclear cells of children with idiopathic nephrotic syndrome. Eur J Clin Invest 1994; 24; 12: 799-805.
  34. Campos A., Rivera F., Egido J., Parera M. T-cell alterations in immunoglobulin A nephropathy. Int J Clin Pharmacol Res 1992; 12; 4: 191-195.
  35. Chabdan S.H., Tesch G.H., Foti R. et al. Interleukin-10 differentially modulates MHC class II expression by mesangial cells and macrophages in vitro and in vivo. Immunology 1998; 94: 72-78.
  36. Chabdan S.H., Tesch G.H., Foti R. et al. Interleukin-10 is a mesangial cell growth factor in vitro and in vivo. Lab Invest 1997; 76: 619-627.
  37. Chen A., Chen W.P., Sheu L.F., Lin C.Y. Pathogenesis of IgA nephropathy: in vitro activation of human mesangial cells by IgA immune complex leads to cytokine secretion. J Pathol 1994; 173; 2: 119-126.
  38. Chen W.P., Lin C.Y. Augmented expression of interleukin-6 and interleukin-1 genes in the mesangium of IgM mesangial nephropathy. Nephron 1994; 68; 1: 10-19.
  39. Chen X., Xu Q., Tang L. Expression of intercellular adhesion molecule-1 and vascular adhesion molecule-1 in kidney of patients with lupus nephritis and membranoproliferative glomerulonephritis. Chung Hua Ping Li Hsueh Tsa Chih 1995; 24; 3: 149-151.
  40. Chrul S., Zochniak K., Zochniak J. et al. CD3-CD25 lymphocyte population and blood serum IL-2R in children with liponephrosis. Pol Merkuriusz Lek 2000; 8; 46: 214-215.
  41. Coleeman D.L., Ruef C. Interleukin-6: an autocrine regulator of mesangial cell growth. Kidney Int 1992; 41: 604-606.
  42. Couser W.G. Pathogenesis of glomerular damage in glomerulonephritis. Nephrol Dial Transplant 1998; 13: 10-15.
  43. Dal Canton A., Fuiano G., Sepe V. et al. Mesangial expression of intercellular adhesion molecule-1 in primary glomerulosclerosis. Kidney Int 1992; 41; 4: 951-955.
  44. Daniel V., Trautmann Y., Konrad M. et al. T-lymphocyte populations, cytokines and other growth factors in serum and urine of children with idiopathic nephrotic syndrome. Clin Nephrol 1997; 47; 5: 289-297.
  45. De Fijter J.W., Daha M.R., Schroeiiers W.E. et al. Increased IL-10 production by stimulated whole blood cultures in primary IgA nephropathy. Clin Exp Immunol 1998; 11: 429-434.
  46. Del Prete G., De Carli M., Almerigogna F. et al. Human IL-10 is produced by both Type 1 Helper (Th1) and Type 2 Helper (Th2)
  47. T cell clones and inhibits their antigen-specific proliferation and Cytokine Production. J Immunol 1993; 150: 353-360.
  48. Diamond J.R., Pesck I. Glomerular tumor necrosis factor and interleukin-1 during acute phase aminonucleoside nephrosis. An immunohistochemical study. Lab Invest 1991; 64: 21-28.
  49. Dohi K., Iwano M., Muraguchi A. et al. The prognostic significance of urinary interleukin-6 in IgA nephropathy. Clin Nephrol 1991; 35; 1: 1-5.
  50. Donovan K.L., Coles G.A., Williams J.D. Tumor necrosis factor-alpha augments the pro-inflammatory interaction between PMN and GBM via a CD18 dependent mechanism. Kidney Int 1995; 48; 3: 698-704.
  51. Douthwaite J.A., Johnson T.S., Haylor J.L. et al. Effects of transforming growth factor-beta1 on renal extracellular matrix components and their regulating proteins. J Am Soc Nephrol 1999; 10; 10: 2109-2119.
  52. Eitner F., Westerhuis R., Burg M. et al. Role of interleukin-6 in mediating mesangial cell proliferation and matrix production in vivo. Kidney Int 1997; 51; 1: 69-78.
  53. Fiorentino D.F., Zlotnik A., Mosmann T.R. et al. IL-10 inhibits cytokine prodution by activated macrophages. J Immunol 1991; 147: 3815-3822.
  54. Floege J., Burns M.W., Alpers C.E. et al. Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model. Kidney Int 1992; 41: 297-309.
  55. Floege J., Eng E., Young B.A. et al. Heparin suppress mesangial cell proliferation and matrix expansion in experimental mesangioproliferative glomerulonephritis. Kidney Int 1993; 43: 369-370.
  56. Fortis C., Galli L., Consogno G. et al. Serum levels of soluble cell adhesion molecules (ICAM-1, VCAM-1, E-selectin) and of cytokine TNF-alpha increase during interleukin-2 therapy. Clin Immunol Immunopathol 1995; 76; 2: 142-147.
  57. Fouqueray B., Boutard V., Philippe C. et al. Mesangial cell-derived interleukin-10 modulates mesangial cell response to lipopolysaccharide. Am J Patol 1995; 147: 176-182.
  58. Frank C., Herrmann M., Fernandez S. et al. Dominant T cells in idiopathic nephrotic syndrome of childhood. Kidney Int 2000; 57; 2: 510-517.
  59. Fujinaka H., Yamamoto T., Feng L. et al. Crucial role of CD8-positive lymphocytes in glomerular expression of ICAM-1 and cytokines in crescentic glomerulonephritis of WKY rats. J Immunol 1997; 158; 10: 4978-4983.
  60. Fukatsu A., Matsuo S., Tamai H. et al. Distribution of interleukin-6 in normal and diseased human kidney. Lab Invest 1991; 65; 1: 61-66.
  61. Fukui M., Nakamura T., Ebihara I. et al. Low-protein diet attenuates increased gene expression of platelet-derived growth factor and transforming growth factor-beta in experimental glomerular sclerosis. J Lab Clin Med 1993; 121: 224-234.
  62. Futrakul N., Butthep P., Patumraj S. et al. Enhanced tumor necrosis factor in the serum and renal hypoperfusion in nephrosis associated with focal segmental glomerulosclerosis. Ren Fail 2000; 22; 2: 213-217.
  63. Garin E.H. Circulating mediators of proteinuria in idiopathic minimal lesion nephrotic syndrome. Pediatr Nephrol 2000; 14; 8-9: 872-878.
  64. Gearing A.J.H., Newman W. Circulating adhesion molecules in disease. Immunol Today 1993; 14; 10: 506-512.
  65. Gharaee-Kermani M., Denholm E.M., Phan S.H. Costimulation of fibroblast collagen and transforming growth factor-beta1 gene expression by monocyte chemoattractant protein-1 via specific receptors. J Biol Chem 1996; 271: 17779-17784.
  66. Gomez Guerrero C., Lopez Armada M.J., Gonzalez E. et al. Soluble IgA and IgG aggregates are catabolized by cultured rat mesangial cells and induce production of TNF-alpha and IL-6, and proliferation. J Immunol 1994; 153; 11: 5247-5255.
  67. Gordon C., Richards N., Howie A.J. et al. Urinary IL-6: a marker for mesangial proliferative glomerulonephritis? Clin Exp Immunol 1991; 86; 1: 145-149.
  68. Hamar P., Peti Peterdi J., Razga Z. et al. Coinhibition of immune and renin-angiotensin systems reduces the pace of glomerulosclerosis in the rat remnant kidney. J Am Soc Nephrol 1999; 10: 234-238.
  69. Hattori M., Nikolic Paterson D.J., Miyazaki K. et al. Mechanisms of glomerular macrophage infiltration in lipid-induced renal injury. Kidney Int Suppl 1999; 71: 47-50.
  70. Hattori T., Fujitsuka N., Kurogi A., Shindo S. Effects of neutralizing antibodies on cytokine treatment for anti-GBM nephritis in mouse. Nippon Jinzo Gakkai Shi 1996; 38; 12: 563-570.
  71. Heck S., Bender K., Kullmann M. et al. I-kβ alpha-independent downregulation of NF-kβ activity by glucocorticoid receptor. EMBO J 1997; 16: 4698-4707.
  72. Henderson B. Therapeutic modulation of cytokines. Annals Rheumatic Disease 1995; 54; 6: 519-523.
  73. Heslan J.M., Branellec A.I., Pilatte Y. et al. Differentiation between vascular permeability factor and IL-2 in lymphocyte supernatants from patients with minimal-change nephrotic syndrome. Clin Exp Immunol 1991; 86; 1: 157-162.
  74. Hill P.A., Lan H.Y., Nikolic Paterson D.J., Atkins R.C. The ICAM-1/LFA-1 interaction in glomerular leukocytic accumulation in anti-GBM glomerulonephritis. Kidney Int 1994; 45; 3: 700-708.
  75. Hirata E., Iwano M., Hirayama T. et al. Rapid measurement of urinary IL-6 by ELISA: urinary IL-6 as a marker of mesangial proliferation. Nippon Jinzo Gakkai Shi 1994; 36; 1: 33-37.
  76. Honkanen E., Teppo A.M., Tornroth T. et al. Urinary transforming growth factor-beta in membranous glomerulonephritis. Nephrol Dial Transplant 1997; 12; 12: 2562-2568.
  77. Horii Y., Iwano M., Hirata E. et al. Role of interleukin-6 in the progression of mesangial proliferative glomerulonephritis. Kidney Int 1993; 39: 71-75.
  78. Hrvacevic R., Topalov D., Stojanovic R. et al. Serum and urinary interleukin-6 levels in patients with primary glomerulonephritis. Srp Arh Celok Lek 1996; 124; 1: 40-42.
  79. Hulton S.A., Shah V., Byrne M.R. et al. Lymphocyte subpopulations, interleukin-2 and interleukin-2 receptor expression in childhood nephrotic syndrome. Pediatr Nephrol 1994; 8; 2: 135-139.
  80. Ihm C.G., Kim J.P., Park J.K. et al. The expression of beta 1 integrin and intercellular adhesion molecule-1 on mesangial cells and its modulation in glomerulonephritis. Korean J Intern Med 1994; 9; 2: 93-98.
  81. Ihm C.G., Park J.K., Hong S.P. et al. Circulating factors in sera or peripheral blood mononuclear cells in patients with membranous nephropathy or diabetic nephropathy. J Korean Med Sci 1997; 12; 6: 539-544.
  82. Inaba S., Takahashi T., Ishihara S. et al. Serum tumor necrosis factor in mesangial IgA glomerulonephritis with macroscopic hematuria in children. Nephron 1996; 72; 4: 518-522.
  83. Isaka Y., Fuijiwara Y., Ueda N. et al. Glomerulosclerosis induced by in vivo transfection of TGF-beta or platelet derived growth factor gene into the rat kidney. J Clin Invest 1993; 92: 2597-2601.
  84. Iwano M., Dohi K., Hirata E. et al. Induction of interleukin-6 synthesis in mouse glomeruli and cultured mesangial cells. Nephron 1992; 62; 1: 58-65.
  85. Janssen U., Ostendorf T., Gaertner S. et al. Improved survival and amelioration of nephrotoxic nephritis in intercellular adhesion molecule-1 knockout mice. J Am Soc Nephrol 1998; 9; 10: 1805-1814.
  86. Jones D.B. Glomerulonephritis. Am J Pathol 1953; 29: 33-43.
  87. Kacprzyk F. The importance of interleukin-6 (IL-6) in pathogenesis and diagnosis of renal glomerular diseases. Postepy Hig Med Dosw 1995; 49; 4: 513-522.
  88. Kacprzyk F., Chrzanowski W. Tumor necrosis factor (TNF) and interleukin-6 (IL-6) in patients with glomerulonephritis. Pol Arch Med Wewn 1996; 96; 3: 224-233.
  89. Kagami S., Kondo S., Loster K. et al. α1β1 integrin-mediated collagen matrix remodeling by rat mesangial cells is differentially regulated by transforming growth factor-beta and platelet-derived growth factor-β. J Am Soc Nephrol 1999; 10; 4: 779-789.
  90. Kanai H., Mitushashi N., Ono R. et al. Increased excretion of urinary transforming growth factor-beta in patients with focal glomerular sclerosis. Nephron 1994; 66: 391-395.
  91. Kawamura O. Antinephritis effect of anti-ICAM-1 monoclonal antibody and anti-LFA-1 monoclonal antibody on accelerated-type anti-GBM nephritis in rats. Nippon Jinzo Gakkai Shi 1994; 36; 2: 103-112.
  92. Ketteler M., Noble N.A., Border W.A. Transforming growth factor-beta and angiotensin II: the missing link from glomerular hyperfiltration to glomerulosclerosis. Annu Rev Physiol 1995; 57: 279-295.
  93. Kitamura M., Burton S., English J. et al. Transfer of a mutated gene encoding active transforming growth factor-beta1 suppresses mitogenesis and IL-1 response in the glomerulus. Kidney Int 1995; 48: 1747-1757.
  94. Kitamura M., Suto T.S. TGF-beta and glomerulonephritis: anti-inflammatory versus prosclerotic actions. Nephrol Dial Transplant 1997; 12; 4: 669-679.
  95. Kitching A.R., Tipping P.G., Power P.A. et al. IL-10 treatment of experimental mesangial proliferative glomerulonephritis reduces glomerular inflammatory cell recruitment and cellular proliferation. J Am Soc Nephrol 1999; 10: 514A.
  96. Kluth D.C., Rees A.J. New approaches to modify glomerular inflammation. J Nephrol 1999; 12; 2: 66-75.
  97. Kobayashi M., Muro K., Yoh K. et al. Effects of FK506 on experimental membranous glomerulonephritis induced by cationized bovine serum albumin in rats. Nephrol Dial Transplant 1984; 13; 10: 2501-2508.
  98. Kulidjiant A.A., Inman R., Isserutz T. Rodent models of lymphocyte migration. Sem Immunol 1999; 11; 2: 85-93.
  99. Lai K.N., Ho R.T., Li P.K. Transforming growth factor-beta mRNA expression in CD4+ T cells from patients with primary glomerulonephritidis. Scand J Urol Nephrol 1996; 30; 3: 223-226.
  100. Lai K.N., Wong K.C., Li P.K. et al. Circulating leukocyte-endothelial adhesion molecules in IgA nephropathy. Nephron 1994; 68; 3: 294-300.
  101. Le Hir M., Haas C., Marino M., Ryffel B. Prevention of crescentic glomerulonephritis induced by anti-glomerular membrane antibody in tumor necrosis factor-deficient mice. Lab Invest 1998; 78; 12: 1625-1631.
  102. Lee W.T., Ahn J.H., Park J.K. et al. Tumor necrosis factor alpha from peripheral blood mononuclear cells of IgA nephropathy and mesangial cell proliferation. Korean J Intern Med 1994; 9; 1: 1-8.
  103. Lee T.W., Kim M.J. Production of interleukin-2 (IL-2) and expression of IL-2 receptor in patients with IgA nephropathy. Korean J Intern Med 1992; 7; 1: 31-38.
  104. Lee T.W., Park J.K., Ahn J.H. et al. Role of mononuclear cells of IgA nephropathy on ICAM-1 expression in mesangial cells. Korean J Intern Med 1998; 13; 1: 27-32.
  105. Levin M., Gascoine P., Turner M.W. et al. A highly cationic protein in plasma and urine of children with steroid-responsive nephrotic syndrome. Kidney Int 1989; 36: 867-877.
  106. Ma L., Zou W., Zhang Z. In situ expression of intercellular adhesion molecule-1 in human glomerulonephritis. Chung Hua I Hsueh Tsa Chih 1995; 75; 4: 201-203.
  107. Maeda H., Kuwahara H., Ichimura Y. et al. TGF-β enchances macrophage ability to produce IL-10 in normal and tumor-bearing mice. J Immunol 1995; 155: 4926-4932.
  108. Maksic D., Spasic P., Dimitrijevic J. et al. Significance of inflammatory cytokines in the pathogenesis of IgA nephropathy. Vojnosanit Pregl 1998; 55; 2: 141-149.
  109. Maksic D.J., Dimitrijevic J., Spasic P. et al. Correlation of inflammatory cytokines in the urine and serum with clinico-laboratory and pathohistologic features in patients with IgA nephropathy. Srp Arh Celok Lek 1996; 124; 1: 37-40.
  110. Mandreoli M., Beltrandi E., Casadei M. et al. Lymphocyte release of soluble IL-2 receptors in patients with minimal change nephropathy. Clin Nephrol 1992; 37; 4: 177-182.
  111. Markovic-Lipkovski J., Muller C.A., Risler T. et al. Mononuclear leukocytes, expression of HLA class II antigens and intercellular adhesion molecule 1 in focal segmental glomerulosclerosis. Nephron 1991; 59; 2: 286-293.
  112. Matsumoto K. Decreased release of IL-10 by monocytes from patients with lipoid nephrosis. Clin Exp Immunol 1995; 102: 603-607.
  113. Matsumoto K. Interleukin-10 inhibits vascular permeability factor release by perypheral blood mononuclear cells in patients with lipoid nephrosis. Nephron 1997; 75: 154-159.
  114. Matsumoto K. Spontaneous and LPS-stimulated release of tumor necrosis factor-alpha by peripheral blood monocytes in patients with focal glomerular sclerosis. Nephron 1995; 70; 1: 118-119.
  115. Matsumoto K., Atkins R.C. Glomerular cells and macrophages in the progression of experimental focal and segmental glomerulosclerosis. Am J Pathol 1989; 134: 933-945.
  116. Matsumoto K., Ohi H., Kanmatsuse K. Interleukin-10 and interleukin-13 synergize to inhibit vascular permeability factor release by perypheral blood mononuclear cells from patients with lipoid nephrosis. Nephron 1997; 77: 212-218.
  117. Matsumoto K., Ohi H., Kanmatsuse K. Interleukin-4 cooperates with interleukin-10 to inhibit vascular permeability factor release by perypheral blood mononuclear cells from patients with minimal-change nephrotic syndrome. Am J Nephrol 1999; 19: 21-27.
  118. Meerschaert J., Furie M.B. The adhesion molecules used by monocytes for migration across endothelium include CD11a/CD18, CD11b/CD18 and VLA-4 on monocytes and JCAM-1, VCAM-1, and other ligands on endothelium. J Immunol 1995; 154; 8: 4099-4112.
  119. Moore K.W., O’Garra A., de Waal Malefyt R. et al. Interleukin-10. Annu Rev Immunol 1993; 1: 165-190.
  120. Moriyama T., Fujibayashi M., Fujiwara Y. et al. Angiotensin II stimulates interleukin-6 release from cultured mouse mesangial cells. J Am Soc Nephrol 1995; 6; 1: 95-101.
  121. Mozes M.M., Bottinger E.P., Jacot T.A. et al. Renal expression of fibrotic matrix proteins and of transforming growth factor-beta isoforms in TGF-beta transgenic mice. J Am Soc Nephrol 1999; 10; 2: 271-280.
  122. Mrowka C., Heintz B., Sieberth H.G. VCAM-1, ICAM-1, and
  123. E-selectin in IgA nephropathy and Schonlein-Henoch syndrome: differences between tissue expression and serum concentration. Nephron 1999; 81; 3: 256-263.
  124. Muller G.A., Muller C.A., Markovic-Lipkovski J. Adhesion molecules in renal diseases. Ren Failure 1996; 18: 711-724.
  125. Mulligan M.S., Johnson K.J., Todd R.F et al. Requirements for leukocyte adhesion molecules in nephrotoxic nephritis. J Clin Invest 1993; 91; 2: 577-587.
  126. Nabel E.G., Shum L., Pompili V.J. et al. Direct transfer transforming growth factor-beta1 gene into arteries stimulates of fibrocellular hyperplasia. Proc Natl Acad Sci USA 1993; 90: 10759-10769.
  127. Nakamura A., Suzuki T., Kohsaka T. Renal tubular function modulates urinary levels of interleukin-6. Nephron 1995; 70; 4: 416-420.
  128. Nakamura T., Ebihara I., Fukui M. et al. Altered glomerular steady-state levels of tumour necrosis factor-alpha mRNA during nephrotic and sclerotic phases of puromycin aminonucleoside nephrosis in rats. Clin Sci Colch 1993; 84; 3: 349-356.
  129. Nakamura T., Miller D., Ruoslahti E. et al. Production of extracellular matrix by glomerular epithelial cells is regulated by transforming growth factor-beta1. Kidney Int 1992; 41: 1213-1221.
  130. Nakazato Y., Hayashida T., Kanno Y. et al. Interleukin (IL)-1 and IL-4 synergistically stimulate NF-IL6 activity and IL-6 production in human mesangial cells. Kidney Int 1998; 54; 1: 71-79.
  131. Neuhaus T.J., Shah V., Callard R.E. et al. T-lymphocyte activation in steroid-sensitive nephrotic syndrome in childhood. Nephrol Dial Transplant 1995; 10; 10: 1348-1352.
  132. Neuhaus T.J., Wadhwa M., Callard R., Barrat T.M. Increased IL-2, IL-4 and interferon-gamma (IFN-gamma) in steroid-sensitive nephrotic syndrome. Clin Exp Immunol 1995; 100; 3: 475-479.
  133. Nguyen T.T., Shou I., Funabiki K. et al. Correlations among expression of glomerular intercellular adhesion molecule 1 (ICAM-1), levels of serum soluble ICAM-1, and renal histopathology in patients with IgA nephropathy. Am J Nephrol 1999; 19; 4: 495-499.
  134. Nishikawa K., Guo Y.J., Miyasaka M. et al. Antibodies to intercellular adhesion molecule-1/lymphocyte function-associated antigen 1 prevents crescent formation in rat autoimmune glomerulonephritis. J Exp Med 1993; 177; 3: 667-677.
  135. Nitta K., Yumura W., Uchida K. et al. Expression of intercellular adhesion molecule-1 on cultured glomerular endothelial cells by pro-inflammatory cytokines and lipopolysaccharide. Nippon Jinzo Gakkai Shi 1995; 42; 3: 361-366.
  136. Noronha I.L., Niemir Z., Stein H. et al. Cytokines and growth factors in renal disease. Nephrol Dial Transplant 1995; 10; 6: 775-786.
  137. Oda T., Kimura M., Hishida A., Yamashita A. et al. Cell-to-cell interaction is required to induce proteinuria in in situ immune complex glomerulonephritis. J Lab Clin Med 1998; 132; 2: 112-123.
  138. Ogawa T., Yorioka N., Ito T. et al. Precise ultrastructural localization of endothelial leukocyte adhesion molecule-1, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in patients with IgA nephropathy. Nephron 1997; 75; 1: 54-64.
  139. Ohta K., Takano N., Seno A. et al. Detection and clinical usefulness of urinary interleukin-6 in the diseases of the kidney and the urinary tract. Clin Nephrol 1992; 38; 4: 185-189.
  140. Okuda S., Languino L.R., Ruoslahti E. et al. Elevated expression of TGF-beta and proteoglycan production in experimental glomerulonephritis. J Clin Invest 68: 453-462.
  141. Ooi B.S., Cohen D.J., Veis J.H. Biology of the mesangial cell in glomerulonephritis - role of cytokines. Proc Soc Exp Biol Med 1996; 213; 3: 230-237.
  142. Ootaka T., Saito T., Soma J. et al. Glomerulointerstitial interaction of adhesion molecules in IgA nephropathy and membranoproliferative glomerulonephritis. Am J Kidney Dis 1997; 29; 6: 843-850.
  143. Ootaka T., Saito T., Soma J. et al. Intercellular adhesion molecule-1/leukocyte function associated antigen-1-mediated and complement receptor type 4-mediated infiltration and activation of glomerular immune cells in immunoglobulin A nephropathy. Am J Kidney Dis 1996; 28; 1: 40-46.
  144. Ozen S., Saatci U., Tinaztepe K. et al. Urinary tumor necrosis factor levels in primary glomerulopathies. Nephron 1994; 66; 3: 291-294.
  145. Pai R., Bassa B., Kirschenbaum M.A., Kamanna V.S. TNF-alpha stimulates monocyte adhesion to glomerular mesangial cells. The role of intercellular adhesion molecule-1 gene expression and protein kinases. J Immunol 1996; 156; 7: 2571-2579.
  146. Parera M., Rivera F., Egido J., Campos A. The role of interleukin-2 (IL-2) and serum-soluble IL-2 receptor cells in idiopathic IgA nephropathy. Clin Immunol Immunopathol 1992; 63; 2: 196-199.
  147. Patey N., Lesavre P., Halbwachs Mecarelli L., Noel L.H. Adhesion molecules in human crescentic glomerulonephritis. J Pathol 1996; 179; 4: 414-420.
  148. Pawluczyk I.Z., Harris K.P. Cytokine interactions promote synergistic fibronectin accumulation by mesangial cells. Kidney Int 1998; 54; 1: 62-70.
  149. Pesce C.M., Striker L.J., Peten E. et al. Glomerulosclerosis at both early and late stages is associated with increased cell turnover in mice transgenic for growth hormone. Lab Invest 1991; 65: 601-605.
  150. Pigott R., Dillon L.P., Hemingway I.H. et al. Soluble forms of
  151. E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells. Biochem Biophys Res Commun 1992; 187; 2: 584-590.
  152. Pippin J.W., Qu Q., Meijer L. et al. Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist. J Clin Invest 1997; 100: 2512-2520.
  153. Pirotzki E., Dellatre R.M., Hellegouarch A. et al. Interleukin-6 production by tumor necrosis factor and lipopolysaccharide-stimulated rat renal cells. Clin Immunol Immunopathol 1990; 56: 271-279.
  154. Ranieri E., Gesualdo L., Petrarulo F., Schena F.P. Urinary IL-6/EGF ratio: a useful prognostic marker for the progression of renal damage in IgA nephropathy. Kidney Int 1996; 50; 6: 1990-2001.
  155. Ring G.H., Lakkis F.G. T lymphocyte-derived cytokines in experimental glomerulonephritis: testing the Th1/Th2 hypothesis. Nephrol Dial Transplant 1998; 13; 5: 1101-1103.
  156. Rothlein R., Mainoff E.A., Czajkowski M. et al. A form of circulating ICAM-1 in human serum. J Immunol 1991; 147; 11: 3788-3793.
  157. Rovin B.H., Dickerson J.A., Tan L.C. Activation of nuclear factor-kappa beta correlates with MCP-1 expression by human mesangial cells. Kidney Int 1995; 48: 1263-1271.
  158. Roy Chaudhury P., Wu B., Mc Donald S. et al. Phenotypic analysis of the glomerular and periglomerular mononuclear cell infiltrates in the Thy 1.1 model of glomerulonephritis. Lab Invest 1995; 72; 5: 524-531.
  159. Ryffel B., Car B.D., Gunn H. et al. Interleukin-6 exacerbates glomerulonephritis in (NZB x NZW) F1 mice. Am J Pathol 1994; 144; 5: 927-937.
  160. Ryffel B., Eugster H., Haas C., Le Hir M. Failure to induce anti-glomerular basement membrane glomerulonephritis in TNF alpha/beta deficient mice. Int J Exp Pathol 1998; 79; 6: 453-460.
  161. Sakurai H., Shigemori N., Hisada Y. et al. Suppression of NF-kappa B and AP-1 activation by glucocorticoids in experimental glomerulonephritis in rats: molecular mechanisms of anti-nephritic action. Biochim Biophys Acta 1997; 1362; 2-3: 252-262.
  162. Saltis J., Agrotis A., Bobil A. Regulation and interactions of transforming growth factor-beta with cardiovascular cells: Implications for development and disease. Clin Exp Pharmacol Physiol 1996; 23: 193-200.
  163. Satriano J.A., Hora K., Shan Z. et al. Regulation of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor-1 by IFN-gamma, tumor necrosis factor-alpha, IgG aggregates, and cAMP in mause mesangial cells. J Immunol 1993; 150: 1971-1978.
  164. Savin V.J., Sharma R., Sharma M. et al. Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis. N Engl J Med 1996; 334: 878-883.
  165. Saxena S., Mittal A., Andal A. Pattern of interleukins in minimal-change nephrotic syndrome of childhood. Nephron 1993; 65; 1: 56-61.
  166. Schalhoub R.J. Pathogenesis of lipoid nephrosis: A disorder of T-cell function. Lancet 1974; 2: 556-560.
  167. Schankland S.J., Johnson R.J. TGF-beta in glomerular disease. Miner Electrolyte Metab 1998; 24: 168-173.
  168. Schiller B., Moran J. Focal glomerulosclerosis in the remnant kidney model - an inflammatory disease mediated by cytokines. Nephrol Dial Transplant 1997; 12; 3: 430-437.
  169. Schnaper H.W. Balance between matrix synthesis and degradation. Pediatr Nephrol 1995; 9; 1: 104-111.
  170. Schneider A., Panzer U., Zahner G. et al. Monocyte chemoattractant protein-1 mediates collagen deposition in experimental glomerulonephritis by transforming growth factor-beta. Kidney Int 1999; 56; 1: 135-144.
  171. Schocklmann H.O., Lang S., Sterzel B. Regulation of mesangial cell proliferation. Kidney Int 1999; 56; 4: 1199-1207.
  172. Segerer S., Nelson P.J., Schlondorff P. Chemokines, Chemokine Receptors, and Renal disease: From Basis Science to pathophysiologic and therapeutic studies. J Am Soc Nephrol 2000; 11; 1: 152-176.
  173. Sharma M., Sharma R., Mc Carthy E.T. et al. The FSGS factor: enrichment and in vivo effect of activity from focal segmental glomerulosclerosis plasma. J Am Soc Nephrol 1999; 10: 552-561.
  174. Shu K.H., Lee S.H., Cheng C.H. et al. Impact of interleukin-1 receptor antagonist and tumor necrosis factor-alpha gene polymorphism on IgA nephropathy. Kidney Int 2000; 58; 2: 783-789.
  175. Soma J., Saito T., Ootaka T. et al. Differences in glomerular leukocyte infiltration between IgA nephropathy and membranoproliferative glomerulonephritis. Nephrol Dial Transplant 1998; 13; 3: 608-616.
  176. Stachowski J.S., Barth C., Michalkiewiez J. et al. Th1/Th2 balance and CD45-positive T cell subsets in primary nephrotic syndrome. Pediatr Nephrol 2000; 14; 8-9: 779-785.
  177. Suranyi M.G., Guasch A., Hall B.M., Myers B.D. Elevated levels of tumor necrosis factor-alfa in the nephrotic syndrome in humans. Am J Kidney Dis 1993; 21; 3: 251-259.
  178. Suthanthiran M., Khanna A., Cukran D. et al. Transforming growth factor-beta1 hyperexpression in African-American end-stage renal disease patients. Kidney Int 1999; 53; 3: 639-644.
  179. Suthanthiran M., Strom T.B. Immunoregulatory drugs: mechanistic basis for use in organ transplantation. Pediatr Nephrol 1997; 11; 5: 651-657.
  180. Suzuki J., Tomizawa S., Arai H. et al. Purification of two types of TNF inhibitors in the urine of the patient with chronic glomerulonephritis. Nephron 1994; 66; 4: 386-390.
  181. Taga K., Mostowski H., Tosato G. Human IL-10 Can Directly Inhibit T-cell growth. Blood 1993; 81: 2964-2971.
  182. Takemura T., Yoshioka K., Murakami K. et al. Cellular localization of inflammatory cytokines in human glomerulonephritis. Virchows Arch 1994; 424; 5: 459-464.
  183. Taniguchi Y., Yorioka N. Interleukin-6 localization and the prognosis of IgA nephropathy. Nephron 1999; 81; 1: 94-98.
  184. Taniguchi Y., Yorioka N., Oda H., Yamakido M. Platelet-derived growth factor, interleukin (IL)-1 beta, IL-6R and tumor necrosis factor-alpha in IgA nephropathy. An immunohistochemical study. Nephron 1996; 74; 4: 652-660.
  185. Thornhill M.H., Wellicome S.M., Mahious P.S. et al. Tumor necrosis factor combines with IL-4 or JFN-gamma to selectively enhance endothelial cell adhesiveness for T cells: The contribution of vascular cell adhesion molecule-dependent and independent binding mechanisms. J Immunol 1991; 146: 592-598.
  186. Tomino Y., Funabiki K., Ohmuro H. et al. Urinary levels of interleukin-6 and disease activity in patients with IgA nephropathy. Am J Nephrol 1991; 11; 6: 459-464.
  187. Tomino Y., Ohmuro H., Kuramoto T. et al. Expression of intercellular adhesion molecule-1 and infiltration of lymphocytes in glomeruli of patients with IgA nephropathy. Nephron 1994; 67; 3: 302-307.
  188. Topaloglu R., Saatci U., Arikan M. et al. T-cell subsets, interleukin-2 receptor expression and production of interleukin-2 in minimal change nephrotic syndrome. Pediatr Nephrol 1994; 8; 6: 649-652.
  189. Velde A., de Waal Malefyt R., Huijbens R. et al. IL-10 stimulates monocyte FcR surface expression and cytotoxic activity. J Immunol 1992; 149: 4048-4052.
  190. Vora M., Romero L.I., Karasek M.A. Interleukin-10 induces E-selectin on smoll and large blood vessel endothelial cells. J Exp Med 1996; 184: 821-829.
  191. Wada J., Shikata K., Makino H. et al. The critical role of intercellular adhesion molecule-1 in Masugi nephritis in rats. Nephron 1996; 73; 2: 264-272.
  192. Wagrowska Danilewicz M., Danilewicz M. Intercellular adhesion molecule-1 (ICAM-1), leucocyte function-associated antigen-1 (LFA-1) and leucocyte infiltration in proliferative human glomerulonephritis. Acta Histochem 1998; 100; 2: 201-215.
  193. Waldnerr R., Noronha I.L., Niemier Z. et al. Expression of cytokines and growth factors in human glomerulonephritides. Pediatr Nephrol 1993; 7: 471-478.
  194. Wanidvoranum C., Strober W. Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis. J Immunol 1993; 151: 6853-6861.
  195. Willems F., Marchant A., Delville J.-P. et al. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol 1994; 24: 1007-1009.
  196. Wilson H.M., Minto A.W., Brown P.A. et al. Transforming growth factor-beta isoforms and glomerular injury in nephrotoxic nephritis. Kidney Int 2000; 57; 6: 2434-2444.
  197. Wolf G., Schneider A., Wenzel U. et al. Regulation of glomerular TGF-beta expression in the contralateral kidney of two-kidney, one-clip hypertensive rats. J Am Soc Nephrol 1998; 9; 5: 763-772.
  198. Wu T.H., Tsai C.Y., Yang W.C. Excessive expression of the tumor necrosis factor-alpha gene in the kidneys of patients with membranous glomerulonephritis. Chung Hua I Hsueh Tsa Chih Taipei 1998; 61; 9: 524-530.
  199. Wu T.H., Wu S.C., Huang T.P. et al. Increased excretion of tumor necrosis factor alpha and interleukin 1 beta in urine from patients with IgA nephropathy and Schonlein-Henoch purpura. Nephron 1996; 74; 1: 79-88.
  200. Yano N., Endoh M., Nomoto Y. et al. Phenotypic characterization of cytokine expression in patients with IgA nephropathy. J Clin Immunol 1997; 17; 5: 396-403.
  201. Yap H.K., Cheung W., Murugasu B. et al. Th1 and Th2 cytokine mRNA profiles in childhood nephrotic syndrome: evidence for increased IL-13 mRNA expression in relapse. J Am Soc Nephrol 1999; 10; 3: 529-537.
  202. Ye X.F., Yorioka N., Oda H. et al. Role of intercellular adhesion molecule-1, lymphocyte function-associated antigen-1, and macrophages in ddY mouse nephropathy. Hiroshima J Med Sci 1997; 46; 2: 75-80.
  203. Yokoyama H., Takaeda M., Wada T. et al. Glomerular ICAM-1 expression related to circulating TNF-alpha in human glomerulonephritis. Nephron 1997; 76; 4: 425-433.
  204. Yoshioka K., Takemura T., Murakami K. et al. In situ expression of cytokines in IgA nephritis. Kidney Int 1993; 44: 825-833.
  205. Yssel H., de Waal Malefyt R., Roncarolo M.G. et al. IL-10 is produced by subsets of human CD4+ T-cell clones and peripheral blood T-cell. J Immunol 1992; 149: 2378-2384.
  206. Yu L.F., Chen X.M., Bo L.Q. Tumor necrosis factor alpha in IgA nephropathy. Chung Hua Nei Ko Tsa Chih 1993; 32; 5: 322-323.
  207. Zahran M., Nessim L. ICAM-1 in pediatric renal disease. Pediatr Nephrol 2000; 14; 6: 48 (abstract).
  208. Ziyadeh F.N., Sharma K., Erichsen M. et al. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by activation of transforming growth factor-beta. J Clin Invest 1994; 93: 536-542.

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