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Том 12 №1 2010 год - Нефрология и диализ

Место блокаторов РАС в нефропротективной стратегии при хронической болезни почек (Обзор литературы)


Николаев А.Ю. Ермоленко В.М.

Аннотация: Представлен обзор литературы, посвященный клиническим аспектам применения блокаторов РАС при хронической болезни почек. Анализируется связь антигипертензивного и антипротеинурического эффектов – ведущих механизмов нефропротекции. Рассматриваются факторы риска осложнений терапии, а также проблема резистентности, связанная с феноменом «ускользания» альдостерона и ренина от блокаторoв РАС.

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Ключевые слова: хроническая болезнь почек, нефропротекция, ингибиторы ангиотензинпревращающего фермента, блокаторы АТI-рецепторов ангиотензина II, острая почечная недостаточность, резистентность к блокаторам РАС, chronic kidney disease, nephroprotection, ACE inhibitors, blockers of АТI-receptors of angiotensin II, acute kidney failure, resistance to RAS blockers

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