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Том 18 №4 2016 год - Нефрология и диализ

Хроническая HCV-инфекция в условиях заместительной почечной терапии


Зубкин М.Л. Червинко В.И. Крюков Е.В. Фролова Н.Ф. Ушакова А.И. Логунов О.В. Котенко О.Н.

Аннотация: Несмотря на значительное снижение распространенности хронической HCV-инфекции среди больных, получающих заместительную почечную терапию, проблема сохраняет свою актуальность в первую очередь для тех, кому планируется или была выполнена пересадка почки, поскольку инфицирование вирусом гепатита С неблагоприятно влияет как на выживаемость реципиентов, так и на сроки функционирования трансплантатов. Применение противовирусной терапии интерфероном ограничивалось значительным числом серьезных нежелательных явлений в диализной популяции и было противопоказано для реципиентов почечного трансплантаа ввиду высокого риска развития необратимых кризов отторжения. Назначение рибавирина, напротив, считалось недопустимым у больных, получающих лечение гемодиализом, в связи с возможностью усугубления нефрогенной анемии. Внедрение в клиническую практику современных препаратов прямого противовирусного действия радикально повысило эффективность и безопасность лечения хронической HCV-инфекции. Однако применение этих препаратов при тяжелой почечной дисфункции имеет ряд важных особенностей, в первую очередь, в связи с возможностью неблагоприятных межлекарственных взаиодействий с иммуносупрессантами, назначаемыми после трансплантации почки. В настоящем обзоре рассматриваются характер течения и прогноз хронической HCV-инфекции у больных на заместительной почечной терапии, а также возможности, условия и тактика применения новых противовирусных препаратов в этой популяции.

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Ключевые слова: хроническая HCV-инфекция, заместительная почечная терапия, препараты прямого противовирусного действия, chronic hepatitis C virus infection, renal replacement therapy direct-acting antiviral agents

Список литературы:
  1. Савин Е.А. Вирусные гепатиты (частные аспекты проблемы). Санкт-Петербург: Наука. 1996. 190.
  2. Станке А.А., Балакирев Э.М., Червинко В.И. и др. Изменения в структуре генотипов НCV у больных, получающих лечение программным гемодиализом. Тезисы VII Российской научно-практической конференции с международным участием «Вирусные гепатиты - эпидемиология, диагностика, лечение и профилактика». 2007. c. 70-71.
  3. Томилина Н.А., Бикбов Б.Т. Заместительная терапия терминальной хронической почечной недостаточности в Российской Федерации в 1998-2013 гг. Отчет по данным Российского регистра заместительной почечной терапии. Часть вторая. Нефрология и диализ. 2016. 18(2): 98-164.AASLD/IDSA HCV Guidance Panel. Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Hepatology. 2015. 62(3): 932-954.
  4. Abbott KC, Lentine KL, Bucci JR et al. Impact of diabetes and hepatitis after kidney transplantation on patients who are affected by hepatitis C virus. J Am Soc Nephrol. 2004. 15: 3166-3174.
  5. Abbott KC, Krista L, Lentine KL, et al. The Impact of Transplantation with Deceased Donor Hepatitis C-Positive Kidneys on Survival in Wait-Listed Long-term Dialysis Patients. American Journal of Transplantation 2004. 4(12): 2032-2037.
  6. Ahmad A, Hasan F, Abdeen S et al. Transjugular liver biopsy in patients with end-stage renal disease. J Vasc Interv Radiol. 2004. 15: 257-260.
  7. Aslinia FM, Wasan SK, Mindikoglu AL et al. End-stage renal disease and African American race are independent predictors of mild liver fibrosis in patients with chronic hepatitis C infection. J Viral Hepat. 2012. 19(5): 371-376.
  8. Badalamenti S, Catania A, Lunghi G et al. Changes in viremia and circulating interferon-alpha during hemodialysis in hepatitis C virus-positive patients: only coincidental phenomena? Am J Kidney Dis. 2003.42:143-150.
  9. Baid-Agrawal S, Pascual M, Moradpour D et al. Hepatitis C virus infection and kidney transplantation in 2014: what’s new? Am J Transplant. 2014. 14: 2206-2220.
  10. Barril G, Traver JA. Prevalence of hepatitis C virus in dialysis patients in Spain. Nephrol Dial Transplant. 1995. 10(6): 78-80.
  11. Belga S, Doucette KE. Hepatitis C in non-hepatic solid organ transplant candidates and recipients: A new horizon. World J Gastroenterol. 2016. 22(4): 1650-1663.
  12. Bhamidimarri KR, Czul F, Peyton A et al. Safety, efficacy and tolerability of half-dose sofosbuvir plus simeprevir in treatment of Hepatitis C in patients with end stage renal disease. J Hepatol. 2015. 63(3): 763-5.
  13. Bianco A, Bova F, Nobile CG et al. Healthcare workers and prevention of hepatitis C virus transmission: exploring knowledge, attitudes and evidence-based practices in hemodialysis units in Italy. BMC Infect Dis. 2013. 13: 76.
  14. Bruchfeld A, Lindahl K, Reichard O et al. Pegylated interferon and ribavirin treatment for hepatitis C in haemodialysis patients. J Viral Hepat 2006. 13(5): 316-321.
  15. Bunchorntavakul C, Maneerattanaporn M, Chavalitdhamrong D. Management of patients with hepatitis C infection and renal disease World J Hepatol. 2015. 7(2): 213-225.
  16. Burra P, Buda A, Livi U et al. Occurrence of post-transplant lymphoproliferative disorders among over thousand adult recipients: Any role for hepatitis C infection? Eur J Gastroenterol Hepatol. 2006. 18: 1065-1070.
  17. Caillard S, Lelong C, Pessione F et al. Post-transplant lymphoproliferative disorders occurring after renal transplantation in adults: Report of 230 cases from the French Registry. Am J Transplant. 2006. 6: 2735-2742.
  18. Carbone M, Cockwell P, Neuberger J. Hepatitis C and kidney transplantation. Int J Nephrol. 2011. 2011: 593291.
  19. Cosio FG, Roche Z, Agarwal A et al. Prevalence of hepatitis C in patients with idiopathic glomerulopathies in native and transplant kidneys. Am J Kidney Dis. 1996. 28(5): 752-758.
  20. Cotler SJ, Diaz G, Gundlapalli S et al. Characteristics of hepatitis C in renal transplant candidates. J Clin Gastroenterol. 2002. 35(2): 191-5.
  21. Craxi A. EASL Clinical Practice Guidelines: management of hepatitis C virus infection. European. Association for the Study of the Liver. J Hepatol. 2011. 55(2): 245-264.
  22. Cruzado JM, Carrera M, Torras J et al. Hepatitis C virus infection and de novo glomerular lesions in renal allografts. Am J Transplant. 2001. 1(2): 171-178.
  23. Desnoyer A, Pospai D, Le MP et al. Pharmacokinetics, safety and efficacy of a full dose sofosbuvir-based regimen given daily in hemodialysis patients with chronic hepatitis C. J Hepatol. 2016. [Epub ahead of print] doi: 10.1016/j.jhep.2016.02.044
  24. EASL Recommendations on Treatment of Hepatitis C 2015. Journal of Hepatology. 2015. 63(1): 199-236.
  25. Eason JD, Gonwa TA, Davis CL et al. Proceedings of consensus conference on simultaneous liver kidney transplantation. Am J Transplant. 2008. 8: 2243-2251.
  26. eMedFusion. Drug interaction chart. 2015. Available from: http://www.hep-druginteractions.org.
  27. Espinosa M, Martin-Malo A, Alvarez de Lara MA et al. High ALT levels predict viremia in anti-HCV-positive HD patients if a modified normal range of ALT is applied. Clin Nephrol. 2000. 54: 151-156.
  28. Etik DO, Ocal S, Boyacioglu AS. Hepatitis C infection in hemodialysis patients: A review. World J Hepatol. 2015. 7(6): 885-895.
  29. Fabrizi F, Dulai G, Dixit V et al. Meta-analysis: interferon for the treatment of chronic hepatitis C in dialysis patients. Aliment Pharmacol Ther. 2003. 18(11-12): 1071-1081.
  30. Fabrizi F, Lunghi G, Andrulli S et al. Influence of hepatitis C virus (HCV) viraemia upon serum aminotransferase activity in chronic dialysis patients. Nephrol Dial Transplant. 1997. 12: 1394-1398.
  31. Fabrizi F, Martin P, Dixit V et al. Biological dynamics of viral load in hemodialysis patients with hepatitis C virus. Am J Kidney Dis. 2000. 35: 122-129.
  32. Fabrizi F, Martin P, Dixit V et al. Hepatitis C virus antibody and survival after renal transplantation: meta-analysis of observational studies. Am J Transplant. 2005. 5: 1452-1461.
  33. Fabrizi F, Martin P, Dixit V et al. Meta-analysis: Effect of hepatitis C virus infection on mortality in dialysis. Aliment Pharmacol Ther. 2004. 20(11-12): 1271-1279.
  34. Fabrizi F, Martin P, Dixit V et al. Post-transplant diabetes mellitus and HCV seropositive status after renal transplantation: Meta-analysis of clinical studies. Am J Transplant. 2005. 5: 2433-2440.
  35. Fabrizi F, Messa P, Martin P. Impact of hemodialysis therapy on hepatitis C virus infection: a deeper insight. Int J Artif Organs. 2009. 32: 1-11.
  36. Fabrizi F, Takkouche B, Lunghi G et al. The impact of hepatitis C virus infection on survival in dialysis patients: meta-analysis of observational studies. J Viral Hepat. 2007. 14: 697-703.
  37. Ferri C, Sebastiani M, Giuggioli D et al. Hepatitis C virus syndrome: A constellation of organ- and non-organ specific autoimmune disorders, B-cell non-Hodgkin’s lymphoma, and cancer. W J Hepatol. 2015. 7(3): 327-343.
  38. Finni PE, Souza ER, Rioja S et al. Is hepatitis C a risk factor to posttransplant diabetes mellitus after renal transplantation in patients using tacrolimus? Transplant Proc. 2004. 36(4): 884-885.
  39. Fissell RB, Bragg-Gresham JL, Woods JD et al. Patterns of hepatitis C prevalence and seroconversion in hemodialysis units from three continents: the DOPPS. Kidn Int. 2004. 65: 2335-2342.
  40. Freeman AJ, Dore GJ, Law MG et al. Estimating progression to cirrhosis in chronic hepatitis C virus infection. Hepatology. 2001. 34: 809-816.
  41. Furusyo N, Hayashi J, Ariyama I et al. Maintenance hemodialysis decreases serum hepatitis C virus (HCV) RNA levels in hemodialysis patients with chronic HCV infection. Am J Gastroenterol. 2000. 95: 490-496.
  42. Gentil MA, Luna E, Rodriguez-Algarra G et al. Incidence of diabetes mellitus requiring insulin treatment after renal transplantation in patients with hepatitis C. Nephrol Dial Transplant. 2002. 17(5): 887-891.
  43. Ghany MG, Strader DB, Thomas DL, Seeff LB. American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology. 2009. 49(4): 1335-1374.
  44. Girndt M, Sester M, Sester U et al. Molecular aspects of T- and B-cell function in uremia. Kidney Int Suppl. 2001. 78: 206-211.
  45. Gordon CE, Balk EM, Becker BN et al. KDOQI US commentary on the KDIGO clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C in CKD. Am J Kidney Dis. 2008. 52: 811-825.
  46. Gressner AM, Sittel D. Plasma pyridoxal 5-phosphate concentrations in relation to apo-aminotransferase levels in normal, uraemic, and post-myocardial infarct sera. J Clin Chem Clin Biochem 1985. 23: 631-636.
  47. Guh JY, Lai Y, Yang CY et al. Impact of decreased serum transaminase levels on the evaluation of viral hepatitis in hemodialysis patients. Nephron. 1995. 69: 459-465.
  48. Hanafiah MK, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology. 2013. 57(4): 1333-1342.
  49. Herwig-Ulf Meier-Kriesche, Friedrich K. Port, Akinlolu O. Ojo et al. Effect of waiting time on renal transplant outcome Kidney International 2000. 58(3): 1311-1317
  50. Hill L. Hepatitis C Virus Direct-Acting Antiviral Drug Interactions and Use in Renal and Hepatic Impairment. Top Antivir Med. 2015. 23(2): 92-96.
  51. Huang JW, Yen CJ, Pai MF et al. Association between serum aspartate transaminase and homocysteine levels in hemodialysis patients. Am J Kidney Dis. 2002. 40: 1195-1201.
  52. Ishida H, Agishi T, Koyama I et al. Hemodialysis paradox: survey on the incidence rate of hepatocellular carcinoma in antihepatitis virus C-antibody-positive chronic hemodialysis patients. Artif Organs. 2001. 25(1): 58-60.
  53. Ishiki Y, Ohnishi H, Muto Y et al. Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and has a potent antihepatitis effect in vivo. Hepatology. 1992. 16: 1227-1235.
  54. Izopet J, Rostaing L, Sandres K et al. Longitudinal analysis of hepatitis C virus replication and liver fibrosis progression in renal transplant recipients. J Infect Dis. 2000. 181: 852-858.
  55. Kamar N, Marion O, Rostaing L et al. Efficacy and safety of sofosbuvir-based antiviral therapy to treat hepatitis C virus infection after kidney transplantation. Am J Transplant 2016. 16(5): 1474-1479.
  56. Kamar N, Rostaing L, Selves J et al. Natural history of hepatitis C virus-related liver fibrosis after renal transplantation. Am J Transplant. 2005. 5(7): 1704-1712.
  57. Kidney Disease: Improving Global Outcomes (KDIGO). KDIGO clinical practice guidelines for the prevention, diagnosis, evaluation, and treatment of Hepatitis C in chronic kidney disease. Kidney Int Suppl. 2008. 109: 1-99.
  58. Kim YS, Cho SG, Cho ML et al. B cell-associated immune profiles in patients with end-stage renal disease (ESRD). Exp Mol Med. 2012. 44(8): 465-472.
  59. Kosloski MP, Dutta S, Zhao W, et al. Fharmacokinetics, safety, and tolerability of next generation direct acting antivirals ABT-493 and ABT-530 in subjects with renal impairtment. J Hepatol. 2016. 2(64): 405-406.
  60. Ladino M, Pedraza F, Roth D. Hepatitis C Virus Infection in Chronic Kidney Disease. J Am Soc Nephrol. 2016. [Epub ahead of print] doi.org/10.1681/asn.2016010030
  61. Lavanchy D. The global burden of hepatitis C. Liver Int. 2009. 29: 74-81.
  62. Liu CH, Kao JH. Treatment of hepatitis C virus infection in patients with end-stage renal disease. J Gastroenterol Hepatol. 2011. 26: 228-239.
  63. Liu CH, Liang CC, Huang KW et al. Transient elastography to assess hepatic fibrosis in hemodialysis chronic hepatitis C patients. Clin J Am Soc Nephrol. 2011. 6: 1057-1065.
  64. Liu C-H, Liang C-C, Liu C-J, et al. Pegylated interferon -2a plus low-dose ribavirin for the retreatment of dialysis chronic hepatitis C patients who relapsed from prior interferon monotherapy GUT. 2009. 58: 314-316.
  65. López-Medrano F, Fernández-Ruiz M, Morales JM et al. Impact of hepatitis C virus infection on the risk of infectious complications after kidney transplantation: data from the RESITRA/REIPI cohort.Transplantation. 2011. 92(5): 543-549.
  66. Marcellin P, Asselah T, Boyer N. Fibrosis and disease progression in hepatitis C. Hepatology. 2002. 36(1): 47-56.
  67. Marinaki S, Boletis J, Sakellariou S et al. Hepatitis C in hemodialysis patients. World J Hepatol. 2015. 7(3): 548-558.
  68. Maruyama A, Partovi N, Yoshida EM et al. A review of direct-acting antivirals for the treatment of hepatitis C in patients with advanced chronic kidney disease. Nephrology Dialysis Transplantation. 2015. 1-6. doi: 10.1093/ndt/gfv361.
  69. McIntyre PG, McCruden EA, Dow BC et al. Hepatitis C virus infection in renal dialysis patients in Glasgow. Nephrol Dial Transplant. 1994. 9: 291-295.
  70. McLaughlin KJ, Cameron SO, Good T et al. Nosocomial transmission of hepatitis С virus within British dialysis center. Nephrol Dial Transplant. 1997. 12: 304-309.
  71. Morales JM, Fabrizi F. Hepatitis C and its impact on renal transplantation. Nat Rev Nephrol. 2015. 11(3): 172-182.
  72. Morales JM, Pascual-Capdevila J, Campistol JM et al. Membranous glomerulonephritis associated with hepatitis C virus infection in renal transplant patients. Transplantation. 1997. 63: 1634-1639.
  73. Muller GY, Zabaleta ME, Arminio A et al. Risk factors for dialysis-associated hepatitis C in Venezuela. Kidney Int. 1992. 41: 1005-1008.
  74. Munoz R, Ramírez E, Fernandez I et al. Correlation between fibroscan, liver biopsy, and clinical liver function in patients with hepatitis C virus infection after renal transplantation. Transplant Proc. 2009. 41: 2425-2426.
  75. Nazario HE, Ndungu M, Modi AA. Sofosbuvir and simeprevir in hepatitis C genotype 1-patients with end-stage renal disease on haemodialysis or GFR №30 ml/min. Liver Int. 2016. 36(6): 798-801.
  76. Negro F, Forton D, Craxì A et al. Extrahepatic morbidity and mortality of chronic hepatitis C. Gastroenterology. 2015. 149(6): 1345-1360.
  77. Neto MC, Draibe SA, Silva AE et al. Incidence of and risk factors for hepatitis B virus and hepatitis C virus infection among hemodialysis and CAPD patients: evidence for environmental transmission. Nephrol Dial Transplant. 1995. 10: 240-246.
  78. Niu MT, Coleman PJ, Alter MJ. Multicenter study of hepatitis C virus infection in chronic hemodialysis patients and hemodialysis center staff members.Am J Kidney Dis. 1993. 22: 568-573.
  79. Oguchi H, Miyasaka M, Tokunaga S et al. Hepatitis virus infection (HBV and HCV) in eleven Japanese hemodialysis units. Clin Nephrol. 1992. 38: 36-43.
  80. Okano J, Shiota G, Kawasaki H. Protective action of hepatocyte growth factor for acute liver injury caused by D-galactosamine in transgenic mice. Hepatology. 1997. 26: 1241-1249.
  81. Okoh EJ, Bucci JR, Simon JF et al. HCV in patients with end-stage renal disease. Am J Gastroenterol. 2008. 103: 2123-2134.
  82. Olmer M, Bouchouareb D, Zandotti C et al. Transmission of the hepatitis C virus in hemodialysis unit: evidence for nosocomial infection. Clin nephrol. 1997. 47: 263-270.
  83. Ono K, Ono T, Matsumata T. The pathogenesis of decreased aspartate aminotransferase and alanine aminotransferase activity in the plasma of hemodialysis patients: the role of vitamin B6 deficiency. Clin Nephrol. 1995. 43: 405-408.
  84. Ozkok A, Yildiz A. Hepatitis c virus associated glomerulopathies. World J Gastroenterol. 2014. 20(24): 7544-7554.
  85. Pahl MV, Gollapudi S, Sepassi L et al. Effect of end-stage renal disease on B-lymphocyte subpopulations, IL-7, BAFF and BAFF receptor expression. Nephrol Dial Transplant. 2010. 25: 205-212.
  86. Pawa S, Ehrinpreis M, Mutchnick M et al. Percutaneous liver biopsy is safe in chronic hepatitis C patients with end-stage renal disease. Clin Gastroenterol Hepatol. 2007. 5: 1316-1320.
  87. Pimenov NN, Chulanov VP, Komarova SV et al. Hepatitis C in Russia: current epidemiology and approaches to improving diagnosis and surveillance. Epidemiol Infect Dis. 2012. 4: 4-10.
  88. Pockros PJ, Reddy KR, Mantry PS et al. Efficacy of direct-acting antiviral combination for patients with hepatitis C virus genotype 1 infection and severe renal impairment or end-stage renal disease. Gastroenterology. 2016. [Epub ahead of print] doi: 10.1053/j.gastro.2016.02.078
  89. Rao VK, Ma J. Chronic viral hepatitis enhances the risk of infection but not acute rejection in renal transplant recipients. Transplantation. 1996. 62(12): 1765-9.
  90. Reddy KR, Bruno S, Rossaro L, et al. Predictors of sustained virologic response among treatment-naive patients with hepatitis C virus genotype 1 when treated with boceprevir plus peginterferonalfa-2b/ribavirin. J Hepatol. 2011. 54: 190.
  91. Rendina M, Schena A, Castellaneta NM et al. The treatment of chronic hepatitis C with peginterferon alfa-2a (40kDa) plus ribavirin in haemodialysed patients awaiting renal transplant. J Hepatol 2007. 46: 768-774.
  92. Rostaing L, Chatelut E, Payen JL et al. Pharmacokinetics of alphaIFN-2b in chronic hepatitis C virus patients undergoing chronic hemodialysis or with normal renal function: clinical implications. J Am SocNephrol. 1998. 9(12): 2344-2348.
  93. Roth D, Bloom R. Selection and management of hepatitis C virus-infected patients for the kidney transplant waiting list. Contrib Nephrol. 2012. 176: 66-76.
  94. Roth D, Cirocco R, Zucker K et al. De novo membranoproliferative glomerulonephritis in hepatitis C virus-infected renal allograft recipients. Transplantation. 1995. 59: 1676-1682.
  95. Roth D, Nelson DR, Bruchfeld A et al. Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4-5 chronic kidney disease (the C-SURFER study): a combination phase 3 study. Lancet. 2015. 386: 1537-1545.
  96. Sawinski D, Kaur N, Ajeti A et al. Successful Treatment of Hepatitis C in Renal Transplant Recipients With Direct-Acting Antiviral Agents. Am J Transplant. 2016. 16(5): 1588-1595.
  97. Sawinski D, Bloom RD. Novel Hepatitis C Treatment and the Impact on Kidney Transplantation.Transplantation. 2015. 99(12): 2458-2466.
  98. Scalea JR, Barth RN, Munivenkatappa R et al. Shorter waitlist times and improved graft survivals are observed in patients who accept hepatitis C virus+ renal allografts. Transplantation. 2015. 99(6): 1192-1196.
  99. Scott DR, Wong JK, Spicer TS et al. Adverse impact of hepatitis C virus infection on renal replacement therapy and renal transplant patients in Australia and New Zealand. Transplantation. 2010. 90: 1165-1171.
  100. Shepard CW, Finelli L, Alter MJ. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis. 2005. 5: 558-567.
  101. Singh T, Guirguis J, Anthony S, et al. Sofosbuvir-based treatment is safe and effective in patients with chronic hepatitis C infection and end stage renal disease: a case series. Liver Int. 2016. 36(6): 802-6.
  102. Stuyver L, Claeys H, Wyseur A et al. Hepatitis C virus in hemodailysis unit: molecular evidence for nosocomial transmission. Kidney Int. 1996. 49: 889-895.
  103. Suda G, Kudo M, Nagasaka A et al. Efficacy and safety of daclatasvir and asunaprevir combination therapy in chronic hemodialysis patients with chronic hepatitis C. J Gastroenterol. 2016. [Epub ahead of print] doi.org/10.1007/s00535-016-1162-8.
  104. Thévenot T, Regimbeau C, Ratziu V et al. Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C in naive patients: 1999 update. J Viral Hepat: 2001. 8(1): 48-62.
  105. Toyoda H, Kumada T, Tada T et al. Safety and efficacy of dual direct-acting antiviral therapy (daclatasvir and asunaprevir) for chronic hepatitis C virus genotype 1 infection in patients on hemodialysis. J Gastroenterol. 2016. [Epub ahead of print] doi.org/10.1007/s00535-016-1174-4.
  106. Toz, H, Nart D, Turan I et al. The acquisition time of infection: a determinant of the severity of hepatitis C virus-related liver disease in renal transplant patients. Clin. Transplant. 2009. 23: 723-731.
  107. Trevizoli JE, de Paula Menezes R, Ribeiro Velasco LF et al. Hepatitis C is less aggressive in hemodialysis patients than in nonuremic patients. Clin J Am Soc Nephrol. 2008. 3(5): 1385-1390.
  108. Van Lеusen R, Adang RPR, de Vries RA et al. Pegylated interferon alfa-2a (40 kD) and ribavirin in haemodialysis patients with chronic hepatitis C. Nephrol Dial Transplant 2008. 23: 721-725.
  109. Wolf JL, Williams D, Coplon N et al. Low aspartate aminotransferase activity in serum of patients undergoing chronic hemodialysis. Clin Chem. 1972. 18(6): 567-568.
  110. Yasuda K, Okuda K, Endo N et al. Hypoaminotransferasemia in patients undergoing long-term hemodialysis: clinical and biochemical appraisal. Gastroenterology. 1995. 109: 1295-1300.
  111. Zampieron A, Jayasekera H, Elseviers M et al. European study on epidemiology and management of hepatitis C virus (HCV) infection in the haemodialysis population. Part 3: prevalence and incidence. EDTNA ERCA J. 2006. 32: 42-44.

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