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Том 8 №1 2006 год - Нефрология и диализ

Молекулярные механизмы интерстициального фиброза при прогрессирующих заболеваниях почек (Обзор литературы)


Чеботарева Н.В. Бобкова И.Н. Козловская Л.В.

Аннотация: Прогрессирование хронических заболеваний почек с нарастанием почечной недостаточности, требующей заместительной почечной терапии на терминальной стадии, является одной из основных проблем в теоретической и практической нефрологии. Всестороннее изучение иммуновоспалительных механизмов поражения почек, в частности большого спектра провоспалительных и профиброгенных молекулярных медиаторов тканевого повреждения, позволило более детально представить значение процессов клеточной пролиферации, накопления и расщепления экстрацеллюлярного матрикса (ЭЦМ) в развитии фиброзно-склеротических изменений почечной ткани, особенно быстром при несостоятельности механизмов самозащиты почки (ингибиторов цитокинов, антиоксидантов, белков теплового шока и др.).

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Ключевые слова: хронический гломерулонефрит, интерстициальный фиброз, мочевые показатели, моноцитарный хемотаксический протеин-1 (МСР-1), трансформирующий фактор роста - β1 (TGF-β1)

Список литературы:
  1. Картамышева Н.Н., Чумакова О.В., Кучеренко А.Г., Сергеева Т.В. Межклеточные взаимодействия в патогенезе тубуло-интерстициального повреждения. Нефрология и диализ 2002; 4(4): 255-259.
  2. Козловская Л.В., Тареева И.Е., Мухин Н.А., Неверов Н.И., Каррыева Б.Ч. Мочевые тесты воспаления при гломерулонефрите. Тер. архив 1994: 6: 11-15.
  3. Назаров П.Г. кн.: Реактанты острой фазы воспаления: Наука 2001: 423 c.
  4. Пальцев М.А., Иванов А.А. кн.: Межклеточные взаимодействия: М.: Медицина 1995.
  5. Плиева О.К. Влияние препаратов с антипротеинурическим действием на экскрецию с мочой больных факторов эндотелия и локально-почечного фибринолиза/протеолиза. Автореферат диссертации на соискание ученой степени кандидата медицинских наук. М.: 2003.
  6. Abbate M., Benigni A., Bertani T., Remuzzi G. Nephrotoxicity of increased glomerular protein traffic. Nephrol Dial Transplant 1999; 14: 304-312.
  7. Abbate M., Zoja C., Corna D. et al. In progressive nephropathies overload of tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation. J Am Soc Nephrol 1998; 9:1213-1224.
  8. Alexopoulus E., Seron D., Hatley R.B. et al. Lupus nephritis: correlation of interstitial cells with glomerular function. Kidney Int 1990; 37: 100.
  9. Alfrey A.C., Fromment D.H., Hammond W.S. Role of iron in tubulointerstitial injury in nephrotoxic serum nephritis. Kidney Int 1989; 36: 753.
  10. Anders H.J., Vielhauer V., Schlondorff D. Chemokines and chemokine receptors are involved in the resolution or progression of renal disease. Kidney Int 2003; 63: 401-415.
  11. Ando T., Okuda S., Yanagida T. et al. Localization of TGFβ and its receptors in the kidney. Miner Electrolyte Metab 1998; 24 (2-3): 149-153.
  12. Baggioli M., Dewald B., Moser B. Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv Immunol 1994; 55: 97-179.
  13. Baricos W.H., Cortez S.L., Deboisblanc M., Xin S. Transforming growth factor β is a potent inhibitor of extracellular matrix degradation by cultured human mesangial cells. J Am Soc Nephrol 1999; 10: 790-795.
  14. Becker G.J., Hewitson T.D. The role of tubulointerstitial injury in chronic renal failure. Curr Opin Nephrol Hypertens 2000; 9: 133-138.
  15. Benigni A. Tubulointerstitial disease mediators of injury: the role of endothelin. Nephrol Dial Transplant 2000; 15(6): 50-52.
  16. Bertani T., Cutillo F., Zoja C., Remuzzi G. et al. Tubulointerstitial lesions mediate renal damage in adriamycin glomerulopathy. Kidney Int 1986; 30: 488-496.
  17. Biancone L., David S., Della Pietra V., Montrucchio G., Cambi V., Camussi G. Alternative pathway activation of complement by cultured human proximal tubular epithelial cells. Kidney Int 1994; 45: 451.
  18. Boffa J.-J., Lu Y., Placier S., Stefanski A., Dussaule J.-C., Chatziantoniou C. Regression of renal vascular and glomerular fibrosis: role of angiotensin II receptor antagonism and matrix metalloproteinases. J Am Soc Nephrol 2003; 14: 1132-1144.
  19. Bohle A., Muller G.A., Wehrmann W. et al. Pathogenesis of chronic renal failure in the primary glomerulopathies, renal vasculopathies and chronic interstitial nephritides. Kidney Int 1996; 54: 2-9.
  20. Border W.A., Noble N.A. Transforming growth factor-b in tissue fibrosis. N Eng J Med 1994; 331: 1286-1292.
  21. Border W.A., Okuda S., Languino L.R., Sporn M.B., Ruoslahti E. Supression of experimental glomerulonephritis by antiserum against transforming growth factor β1. Nature 1990; 346: 371-374.
  22. Bottinger E.P., Bitzer M. TGF-β signaling in renal disease. J Am Soc Nephrol 2002; 13: 2600-2610.
  23. Burton C.J., Combe C., Walls J., Harris K.P.G. Secretion of chemokines and cytocines by tubular epithelial cells in responce to proteins. Nephrol Dial Transplant 1999; 14: 2628-2633.
  24. Cockwell P., Howie A.J., Adu D. et al. In situ analysis of C-C chemokine mRNA in human glomerulonephritis. Kidney Int 1998; 54(3): 827.
  25. D'Amico G. Influence of clinical and histilogical features on actuarial renal survival in adult patients with idiopathic IgA nephropathy, membranous nephropathy and membranoproliferative glomerulonephritis: survey of the recent literature. Am J Kidney Dis 1992; 20: 315-323.
  26. D'Amico G. Tubulo-interstitial damage in glomerular diseases: its role in the progression of the renal damage. Nephrol Dial Transplant 1998; 13 (1): 80-85.
  27. David S., Biancone L., Caserta C., Bussolati B., Cambi V., Camussi G. Alternative pathway complement activation induces proinflammatory activity in human proximal tubular epithelial cells. Nephrol Dial Transplant 1997; 12: 51-56.
  28. Douthwaite J.A., Johnson T.S., Haylor J.L., Watson P., El Nahas A.M. Effects of transforming growth factor-β on renal extracellular matrix components and their regulating proteins. J Am Soc Nephrol 1999; 10: 2109-2119.
  29. Eddy A.A. Proteinuria and interstitial injury. Nephrol Dial Transplant 2004; 19: 277-281.
  30. Eddy A.A., McCulloch L., Adams J., Liu E. Interstitial nephritis induced by protein-overload proteinuria. Am J Pathol 1989; 135: 719-733.
  31. Evan A.P., Tanner G.A. Proximal tubule morphology after single nephron obstruction in the rat kidney. Kidney Int 1986; 30: 818-827.
  32. Fan J.M., Ng Y.Y., Hill P.A. et al. Transforming growth factor beta regulates tubular epithelial-myofibroblasts transdifferentiation in vitro. Kidney Int 1999; 56(4): 1455-1467.
  33. Flaumenhaft R., Abe M., Mignatti P., Rifkin D.B. Basic fibroblast growth factor-induced activation of latent transforming growth factor β in endothelial cells: regulation of plasminogen activator activity. J Cell Biol 1992; 118: 901-909.
  34. Gilbert R.E., Akdeniz A., Allen T.J., Jerums G. Urinary transforming growth factor-β in patients with diabetic nephropathy: implications for the pathogenesis of tubulointerstitial pathology. Nephrol Dial Transplant 2001; 16: 2442-2443.
  35. Goumenos D.S., Tsakas S., Nahas A.M.E., Alexandri S., Oldroyd S., Kalliakmani P., Vlachojannis J.G. Transforming growth factor-ß1 in the kidney and urine of patients with glomerular disease and proteinuria. Nephrol Dial Transplant 2002; 17: 2145-2152.
  36. Goumenos D.S., Tsamandas A.C., Oldroyd S., Sotsiou F., Tsakas S., Petropoulou C., Bonikos D., Nahas M.E., Vlachojannis J.G. Transforming growth factor β1 and myofibroblasts: a potential pathway towards renal scarring in human glomerular disease. Nephron 2001; 87 (3): 240-248.
  37. Guijarro C., Egido J. Transcription factor- κB (NF- κB) and renal disеase. Kidney Int 2001; 59: 415-424.
  38. Honkanen E., Teppo A., Tornroth T., Groop P., Gronhagen-Riska C. Urinary transforming growth factor-beta 1 in membranous glomerulonephritis. Nephrol Dials Transplant 1997; 12 (12): 2562-2568.
  39. Houlihan C., Akdeniz A., Tsalamandris C., Cooper M.E., Jerums G., Gilbert R.E. Urinary transforming growth factor β excretion in patients with hypertension, type 2 diabetes and elevated albumin excretion rate. Diabetes Care 2002; 25: 1072-1077.
  40. Isaka Y., Brees D.K., Ikegaya K. Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nat Med 1996; 2: 418-423.
  41. Kelley V.R., Rovin B.H. Chemokines: therapeutic targets for autoimmune and inflammatory renal disease. Springer Seminars in Immunopathology 2003; 24: 411-421.
  42. Kim S.-J., Angel P., Lafyatis R. et al. Autoinduction of transforming growth factor β1 is mediated by the AP-1 complex. Mol Cell Biol 1990; 10: 1492-1497.
  43. Kriz W., Hartmann I., Hosser H. et al. Tracer studies in the rat demonstrate misdirected filtration and peritubular filtrate spreading in nephrons with segmental glomerulosclerosis. J Am Soc Nephrol 2001; 12: 496-506.
  44. Liu Z.-H., Chen S.-F., Zhou H., Chen H.-P., Li L.-S. Glomerular expression of C-C chemokines in different typs of human crescentic glomerulonephritis. Nephrol Dial Transplant 2003; 18: 1526-1534.
  45. Lloyd C.M., Minto A.W., Dorf M.E. et al. RANTES and Monocyte Chemoattractant Protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescentic formation and interstitial fibrosis. J Exp Med 1997; 185(7): 1371-1380.
  46. Mackensen S., Grund K.E., Sindjie M., Bohle A. Influence of the renal cortical interstitium on the serum creatinine clearance in different chronic sclerosing interstitial nephritides. Nephron 1979; 24: 30-34.
  47. Magil A.B. Tubulointerstitial lesions in human membranous glomerulonephritis: Relationship to proteinuria. Am J Kidney Dis 1995; 25: 375-379.
  48. Marcussen N. Atubular glomeruli in cisplatin-induced chronic interstitial nephropathy. APMIS 1990; 98: 1087-1097.
  49. Marcussen N. Tubulointerstitial damage leads to atubular glomeruli: significance and possible role in progression. Nephrol Dial Transplant 2000; 15 (Supple 6): 74-75.
  50. Matsusaka T., Katori H., Miyazaki Y. et al. Angiotensin II as a player in fibrosis. Nephrol Dial Transplant 2000; 15 (6): 64-65.
  51. Meyer T.W. Tubular injury in glomerular disease. Kidney Int 2003; 63: 774-787.
  52. Muller G.A., Marcovic-Lipkovski J., Frank J. The role of interstitial cells in the progression of renal diseases. J Am Soc Nephrol 1992; 2: 198.
  53. Munger J.S., Harpel J., Gleizes P.E., Mazzieri R., Nunes I., Rifkin D.B. Latent transforming growth factor-β: structural features and mechanism of activation. Kidney Int 1997; 51: 1376-1382.
  54. Ng Y.Y., Huang T.P., Yang W.C. Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats. Kidney Int 1998; 54: 864-876.
  55. Ohashi R., Kitamura H., Yamanaka N. Peritubular capillary injury during the progression of experimental glomerulonephritis in rats. J Am Soc Nephrol 2000; 11: 47-56.
  56. Okada H., Danoff T.M., Kalluri R., Neilson E.G. The early role of FSP1 in epithelial-mesenchymal transformation. Am J Physiol 1997; 273: 563-574.
  57. Okon K. Tubulo-interstitial changes in glomerulopathy. Prognostic significance. Pol J Pathol 2003; 54 (3): 163-169.
  58. Okuda S., Languino L.R., Ruoslahti E., Border W.A. Elevated expression of transforming growth factor β and proteoglycan production in experimental glomerulonephritis: possible role in expansion of the mesangial extracellular matrix. J Clin Invest 1990; 86: 453-462.
  59. Panzer U., Thaiss F., Zahner G. et al. Monocyte chemoattractant protein-1 and osteopontin differentially regulate monocytes recruitment in experimental glomerulonephritis. Kidney Int 2001; 59: 1762-1769.
  60. Prodjosudjadi W., Gerritsma J.S., Klar-Mohamad N. et al. Production and cytokine-mediated regulation of monocyte chemoattractant protein-1 by human proximal tubular epithelial cells. Kidney Int 1995; 48: 1477-1486.
  61. Remuzzi G., Bertani T. Pathophysiology of progressive nephropathies. The New England Journal of Medicine 1998; 12: 1448-1455.
  62. Risdon R.A., Sloper J.C., Wardener H.E. Relationship between renal function and histologic changes in renal-biopsy specimens from patients with persistents glomerular nephritis. Lancet 1968; 2: 363-370.
  63. Roberts A.B. Molecular and cell biology of TGF-beta. Miner Electrolyte Metab 1998; 24(2-3): 111-119.
  64. Rodemann H.P., Muller G.A., Knecht A., Norman J.T., Fine L.G. Fibroblasts of rabbit kidney in culture. I. Characterization and identification of cell-specific marcers. Am J Physiol 1991; 261: 283-291.
  65. Sato M., Muragaki Y., Saika S., Roberts A.B., Ooshima A. Targeted disruption of TGF-β1/Smad3 signaling protect against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 2003; 15: 112(10): 1486-1494.
  66. Schainuk L., Striker G., Cutler R. et al. Structural-functional correlations in renal disease. Hum Pathol 1970; 1: 631-641.
  67. Schena F.P. Cytokine network and resident renal cells in glomerular diseases. Nephrol Dial Transplant 1999; 14 (1): 22-26.
  68. Schnaper H.W., Hayashida T., Hubchak S.C., Poncelet A.-C. TGF-β signal transduction and mesangial cell fibrogenesis. Am J Physiol Renal Physiol 2003; 284 (2): 243-252.
  69. Schneider A., Panzer U., Zahner G. et al. Monocyte chemoattractant protein-1 mediates collagen deposition in experimental glomerulonephritis by transforming growth factor-beta. Kidney Int 1999; 56 (1): 135-144.
  70. Schreiner G.F. Renal toxicity of albumin and other lipiproteins. Curr Opin Nephrol Hypertens 1995; 151: 369-373.
  71. Segerer S., Nelson P., Schlondorff D. Chemokines, Chemokine Receptors and renal disease: from basic science to pathophysiologic and therapeutic studies. J Am Soc Nephrol 2000; 11: 152-176.
  72. Shirato K., Osava H., Kaizuka M., Nakamura N., Sugawara T., Nakamura M., Tamura M., Yamabe H., Okumura K. Trombin stimulates production of fibronectin by human proximal tubular epithelial cell via a transforming growth factor β-dependent mechanism. Nephrol Dial Transplant 2003; 18: 2248-2254.
  73. Stephan M., Conrad S., Eggert T. et al. Urinary concentration and tissue messenger RNA expression of monocyte chemoattractant protein-1 as an indicator of the degree of hydronephrotic atrophy in partial ureteral obstruction. J Urol 2002; 167: 1497-1502.
  74. Strutz F., Neilson E.G. New insights into mechanism of fibrosis in immune renal injury. Springer Semin Immunopathol 2003; 24: 459-476.
  75. Taal M.W., Zandi-Nejad K., Weening B. et al. Proinflammatory gene expression and macrophage recruitment in the rat remnant kidney. Kidney Int 2000; 58: 1664-1676.
  76. Tam F.W.K., Sanders J.-S., George A., Hammad T., Miller C., Dougan T., Cook H.T., Kallenberg C.G.M., Gaskin G., Levy J.B., Pusey C.D. Urinary monocyte chemoattractant protein-1 (MCP-1) is a marker of active renal vasculitis. Nephrol Dial Transplant 2004; 19: 2761-2768.
  77. Terrell T.G., Working P.K., Chow C.P., Green J.D. Pathology of recombinant human transforming growth factor β1 in rats and rabbits. Int Rev Exp Pathol 1993; 51: 3590-3594.
  78. Tesch G.H., Maifert S., Schwarting A. et al. Monocyte chemoattractant protein -1-dependent leukocytic infiltrates are responsible for autoimmunune disease in MRL-faslpr mice. J Exp Med 1999; 190: 1813.
  79. Tesch G.H., Schwarting A., Kinoshita K., Lan H.Y., Rollins B.J., Kelley V.R. Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis. J Clin Invest 1999; 103(1): 73-80.
  80. Viedt C., Dechend R., Fei J., Hansch G.M., Kreuzer J., Orth S.R. MCP-1 induces inflammatory activation of human tubular epithelial cells: involvement of the transcription factors, nuclear factor kB and Activating protein-1. J Sm Soc Nephrol 2002; 13: 1534-1547.
  81. Viedt C., Orth S. Monocyte chemoattractant protein-1 (MCP-1) in the kidney: does it more than simply attract monocytes? Nephrol Dial Transplant 2002; 17: 2043-2047.
  82. Wada T., Furuichi K., Segawa C., Shimizu M., Sakai N., Takeda S. et al. MIP-1α and MCP-1 contribute crescents and interstitial lesions in human crescentic glomerulonephritis. Kidney Int 1999; 56: 995-1003.
  83. Wada T., Yokoyama H., Furuichi K. et al. Intervention of crescentic glomerulonephritis by antibodies to monocyte chemotactic and activating factor (MCAF/MCP-1). FASEB J 1996; 10: 1418-1425.
  84. Wada T., Yokoyama H., Kobayashi K. Chemokines: new target molecules in renal diseases. Clin Exp Nephrol 2000; 4: 273-280.
  85. Wada T., Yokoyama H., Su S., Mukaida N., Iwano M., Dohi K., Takahashi Y., Sasaki T., Furuichi K., Segawa C., Hisada Y., Ohta S., Takasawa K., Kobayashi K., Matsushima K. Monitoring urinary levels of Monocyte chemotactic and activating factor reflects disease activity of lupus nephritis. Kidney Int 1996; 49: 761-767.
  86. Wadle E.N. Nuclear factor κB for nephrologists. Nephrol Dial Transplant 2001; 16: 1764-1768.
  87. Wang S., Hirschberg R. BMP7 antagonizes TGF-β-dependent fibrogenesis in mesangial cells. Am J Physiol Renal Physiol 2003; 284: 1006-1013.
  88. Wang Y., Rangan G.K., Tay Y.C. et al. Induction of monocyte chemoattractant protein-1 by albumin is mediated by nuclear factor kB in proximal tubule cells. J am Soc Nephrol 1999; 10: 1204-1213.
  89. Wehrmann M., Bohle A., Held H., Schumm G., Kendziorra H., Presslar H. Long-term prognosis of focal sclerosis glomerulonephritis. An analysis of 250 cases with particular regard to tubulointerstitial changes. Clin Nephrol 1990; 33: 115-122.
  90. Wolf G. Angiotensin II as a mediator of tubulointerstitial injury. Nephrol Dial Transplant 2000; 15 (6): 61-63.
  91. Yamamoto T., Noble N.A., Cohen A.H., Nast C.C., Hishida A., Gold L.I., Border W.A. Expression of transforming growth factor β isoforms in human glomerular diseases. Kidney Int 1996; 49: 461-469.
  92. Yamamoto T., Noble N.A., Miller D.E., Border W.A. Sustained expression of TGF-β1 underlies development of progressive kidney fibrosis. Kidney Int 1994; 45: 916-927.
  93. Yokoyama H., Wada T., Furuichi K., Segawa C., Shimizu M., Kobayashi K. et al. Urinary levels chemokines (MCAF/MCP-1, IL-8) reflect distinct disease activities and phases of human IgA nephropathy. J Leukocyte Biol 1998; 63: 493-499.

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