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Том 8 №3 2006 год - Нефрология и диализ

Сосудистое поражение почек при антифосфолипидном синдроме (Обзор литературы)

Козловская Н.Л.

Аннотация: Последние десятилетия отмечены возрастающим интересом исследователей к широкому кругу заболеваний, в основе прогрессирования которых лежат механизмы сосудистого повреждения. Он включает в себя атеросклероз, гипертоническую болезнь, сахарный диабет, системные васкулиты. В конце XX в. в этот круг вошел описанный G.R.V. Hughes антифосфолипидный синдром (АФС) - симптомокомплекс, проявляющийся венозными и/или артериальными тромбозами, привычным невынашиванием беременности и тромбоцитопенией, которые сочетаются с гиперпродукцией антител к фосфолипидам (АФЛ) [50, 54, 55]. По современным представлениям последние обуславливают развитие гиперкоагуляционного состояния свертывающей системы крови (аутоиммунной тромбофилии), реализующегося тромбообразованием в сосудах как крупного, так и малого калибра, что может приводить к развитию полиорганной ишемии, а иногда и полиорганной недостаточности

Для цитирования: Козловская Н.Л. Сосудистое поражение почек при антифосфолипидном синдроме (Обзор литературы). Нефрология и диализ. 2006. 8(3):206-219. doi:

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Ключевые слова: антифосфолипидный синдром, антифосфолипидные антитела, АФС-ассоциированная нефропатия, тромботическая микроангиопатия

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