nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-1026Research ArticleНАБЛЮДЕНИЯ ИЗ ПРАКТИКИCASE REPORTSМалоиммунный полулунный гломерулонефрит как осложнение первичного cиндрома ШегренаPauci-immune crescentic glomerulonephritis complicating Sjögren’s syndromeКаганМ. Ю.KaganM. Iu.mkaganorenburg@yahoo.comВоробьеваО. А.VorobyevaO. A.noemail@neicon.ruГУЗ «Областная детская клиническая больница», г. ОренбургRussian FederationГУЗ «Ленинградское областное патологоанатомическое бюро» г. Санкт-ПетербургRussian Federation2009190620251115356Copyright © Каган М.Ю., Воробьева О.А., 20252025Каган М.Ю., Воробьева О.А.Kagan M.I., Vorobyeva O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/1026

Синдром Шегрена (СШ) - аутоиммунное заболевание, для которого характерны лимфоцитарная инфильтрация и нарушение функций слюнных, слезных и других экзокринных желез. Первичный синдром Шегрена (ПСШ) встречается в основном у взрослых, наиболее часто у женщин среднего возраста, и редко у детей. Тубулоинтерстициальный нефрит с субклинической почечной дисфункцией, является частым ренальным осложнением ПСШ. Очень редко при ПСШ развивается гломерулонефрит (ГН), который в большинстве случаев представлен мембранозной нефропатией или мембрано-пролиферативным ГН. Мы приводим описание малоиммунного полулунного ГН, осложнившего ПСШ у 12-летней девочки. По имеющимся у нас данным подобное сочетание не было ранее описано у детей.

Primary Sjogren’s syndrome (PSS) is an autoimmune disease characterized by lymphocytic infiltration of the salivary and lacrimal glands. PSS is common in adults, especially in middle aged women, but rare in children. The most common form of renal involvement in PSS is a tubulointerstitial nephritis. Renal dysfunction is usually mild or subclinical. Glomerulonephritis (GN) is rare in patients with PSS and most patients have membranous or membranoproliferative GN. We report a 12-year-old girl with PSS who developed a pauci immune crescentic GN. To our knowledge, this association has not been previously described in children.

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The authors declare that there are no conflicts of interest present.