nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-1030Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESБезопасно ли внутривенное введение низкомолекулярного декстрана железа для коррекции анемии у больных с хронической почечной недостаточностью?Low molecular weight dextran of iron: is it safely for treatment of anemia in patients with chronic kidney disease?ЕрмоленкоВ. М.ErmolenkoV. M.nephrology@mail.ruМихайловаН. А.MikhaylovaN. A.nephrology@mail.ruБатэрдэнэС. .BaterdeneS. .nephrology@mail.ruКафедра нефрологии и гемодиализа ГОУ ДПО РМАПО Росздрава, г. МоскваRussian Federation200919062025112109116Copyright © Ермоленко В.М., Михайлова Н.А., Батэрдэнэ С..., 20252025Ермоленко В.М., Михайлова Н.А., Батэрдэнэ С...Ermolenko V.M., Mikhaylova N.A., Baterdene S...Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/1030

В сравнительном плане обобщены литературные данные о соединениях железа, используемых для в/в введения в первую очередь у больных с ХБП, находящихся на заместительной терапии. Особое внимание уделено зарегистрированному в конце 2008 г. низкомолекулярному декстрану железа (космоферу), уже успешно в течение длительного времени используемого в США и зарегистрированного кроме России еще в 50 странах. Анализ литературных данных позволил сделать однозначный вывод, что космофер по безопасности и эффективности практически не уступает зарекомендовавшему себя на российском рынке веноферу, а благодаря ряду структурных особенностей допускает одномоментное использование больших доз препарата, экономя рабочее время персонала и удешевляя лечение.

In this work literature data conserning iron compounds used for intravenous administration in patients with CKD treated by dialysis were summarized. Special attention is paid to low molecular weight dextran of iron (Cosmofer) registered in 2008 and being successfully used during a significant period of time in the United States. It is already registered in 50 countries besides Russia. Analysis of published data allows us make an unambiguous conclusion that Cosmofer provides practically equal safety and efficacy as Venofer - already well-known drug in Russian market. On the other hand, due to some structural features a single-step use of large doses of Cosmofer is possible. This saves time of the personnel and makes therapy cheaper.

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The authors declare that there are no conflicts of interest present.