nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-1351Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESНеамилоидная форма отложения моноклональных иммуноглобулинов в почках (Обзор литературы)Non-amyloid form of monoclonal immunoglobulin deposition disease (Review)ВоробьеваО. А.VorobyevaO. A.slvorob@lopab.spb.ruХмельницкаяН. М.KhmelnitskayaN. M.noemail@neicon.ruНастС. .NastC. C.noemail@neicon.ruКоэнА. .CohenA. H.noemail@neicon.ruКафедра патологической анатомии с курсом цитологии, Санкт-Петербургская медицинская академия последипломного образования, г. Санкт-Петербург, РоссияRussian FederationОтдел патологии и лабораторной медицины, Медицинский центр Cedars-Sinai, г. Лос-Анжелес, СШАRussian Federation20072306202592149154Copyright © Воробьева О.А., Хмельницкая Н.М., Наст С..., Коэн А..., 20252025Воробьева О.А., Хмельницкая Н.М., Наст С..., Коэн А...Vorobyeva O.A., Khmelnitskaya N.M., Nast C.C., Cohen A.H.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/1351

Моноклональные иммуноглобулины, а именно их компоненты в виде легких или тяжелых цепей, являются продуктом функционирования клона плазматических клеток и медиаторами специфических тканевых изменений, наблюдаемых при плазмоцитарных дискразиях. Патогенный эффект может реализовываться несколькими путями: увеличением концентрации молекул моноклонального иммуноглобулина, изменением их физико-химических свойств, или же сочетанием этих факторов одновременно. Термином «плазмоцитарная дискразия» принято обозначать любое нарушение функции плазматических клеток, сопровождающееся, как правило, продукцией аномальных по количеству и качеству иммуноглобулинов или их компонентов [3, 7]. Для такого патологического белка - моноклонального иммуноглобулина - применяется термин «парапротеин». Поражение ткани почки при плазмоцитарных дискразиях имеет несколько форм: амилоидная и неамилоидная формы отложения моноклональных иммуноглобулинов и нефропатия Бенс-Джонса.

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