nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-1356Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESКомплемент-фиксирующие антитела к BK вирусу у реципиентов аллотрансплантатов почкиComplement-fixing antibodies to BK virus in kidney transplant recipientsЕжковИ. А.EzhkovI. A.ezhkovv@rambler.ruКимИ. Г.KimI. G.noemail@neicon.ruСтроковА. Г.StrokovA. G.noemail@neicon.ruБарановаФ. С.BaranovaF. S.noemail@neicon.ruАбрамовВ. Ю.AbramovV. Yu.noemail@neicon.ruФГУ НИИ трансплантологии и искусственных органов Росздрава РФ, Московский городской нефрологический центр, городская клиническая больница № 52; г. МоскваRussian Federation20072306202592177180Copyright © Ежков И.А., Ким И.Г., Строков А.Г., Баранова Ф.С., Абрамов В.Ю., 20252025Ежков И.А., Ким И.Г., Строков А.Г., Баранова Ф.С., Абрамов В.Ю.Ezhkov I.A., Kim I.G., Strokov A.G., Baranova F.S., Abramov V.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/1356

BK-вирусная нефропатия трансплантата, вызванная реактивацией BK вируса является важной причиной потери аллотрансплантата почки. В настоящей работе нами представлены данные о комплемент-фиксирующих антителах (КФА) к BK вирусу у реципиентов аллотрансплантатов почки, больных, находящихся на программном гемодиализе и доноров крови. КФА были выявлены у 63/181 (35%) реципиентов аллотрансплантатов почки, у 7/41 (17%) больных, находящихся на программном гемодиализе, и у 3/38 (8%) доноров крови. Титры КФА у больных, находящихся на программном гемодиализе, и доноров крови не превышали 1:20, тогда как у реципиентов аллотрансплантатов почки выявлялись и более высокие титры (1:40 и 1:80). Нами проанализирована частота выявления КФА в зависимости от сроков после трансплантации; в группе со сроком более года она составила 45%, тогда как до года только 16%. Результаты данного исследования подтверждают имеющуюся точку зрения о высокой частоте реактивации BKV у реципиентов аллотрансплантата почки и являются первой попыткой получить сведения о BK вирусной инфекции в популяции реципиентов аллотрансплантатов почки в России.

BK virus-associated nephropathy caused by reactivation of BK virus is a major reason of allograft loss. In this article we present our findings for complement-fixing antibodies (CFA) to BK virus in kidney transplant recipients, patients on hemodialysis and healthy blood donors. CFA were observed in 63/181 (35%) of kidney transplant recipients, 7/41 (17%) of patients on hemodialysis and in 3/38 (8%) of blood donors. The patients on hemodialysis and blood donors had maximal titers 1:20 whereas the kidney transplant recipients had CFA titers 1:40 or 1:80. We also analyzed the frequency of revealing CFA a function of duration of posttransplant period; it was 45% in group of patients with posttransplant period more than 1 year, and only 16% in group about one year. This work provides the first set of data about BK virus infection in the population of kidney transplant recipients in Russia. The results confirm an existing point of view that there is high frequency of BK virus reactivation in kidney transplant recipients.

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The authors declare that there are no conflicts of interest present.