nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-1513Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESЗначение генетики и протеомики в понимании механизмов развития и прогрессирования нефротического синдрома у детейThe role of genetics and proteomics in understanding the mechanisms of progression of nephrotic syndrome in childrenИгнатоваМ. С.IgnatovaM. S.nephrolog@pedklin.ruШатохинаО. В.ShatokhinaO. V.noemail@neicon.ruПриходинаЛ. С.PrikhodinaL. S.noemail@neicon.ruФГУ «МНИИ педиатрии и детской хирургии росмедтехнологий», г. МоскваRussian Federation20072306202594401407Copyright © Игнатова М.С., Шатохина О.В., Приходина Л.С., 20252025Игнатова М.С., Шатохина О.В., Приходина Л.С.Ignatova M.S., Shatokhina O.V., Prikhodina L.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/1513

Под нефротическим синдромом (НС) понимается клинический симптомокомплекс, включающий: - протеинурию с потерей белка с мочой 3 и более граммов за сутки у взрослых, ³50 мг/кг/24 ч или ³40 м2/ч (утренняя порция) у детей; - гипопротеинемию с гипоальбуминемией (альбумин плазмы £25 г/л); - гиперлипидемию, включающую гиперхолестеринемию и триглицеридемию; - отеки (не обязательно, так как возможен «неполный», безотечный НС). В связи с бурным развитием генетики, которое произошло после открытия генома человека, в ведущих нефрологических изданиях появились публикации, указывающие на необходимость изучения нефрологами основ генетики, что позволит улучшить диагностику, в том числе различных вариантов НС, и облегчит выбор терапевтической тактики

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The authors declare that there are no conflicts of interest present.