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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nid</journal-id><journal-title-group><journal-title xml:lang="ru">Нефрология и диализ</journal-title><trans-title-group xml:lang="en"><trans-title>Nephrology and Dialysis</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1680-4422</issn><issn pub-type="epub">2618-9801</issn><publisher><publisher-name>Российское диализное общество</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">nid-1524</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Молекулярные механизмы интерстициального фиброза при прогрессирующих заболеваниях почек (Обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Molecular mechanisms of interstitial fibrosis in the progression of renal diseases (review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чеботарева</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tchebotareva</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бобкова</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Bobkova</surname><given-names>I. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козловская</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlovskaja</surname><given-names>L. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Отдел нефрологии НИЦ ММА им. И.М.Сеченова, г. Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>23</day><month>06</month><year>2025</year></pub-date><volume>8</volume><issue>1</issue><fpage>26</fpage><lpage>35</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чеботарева Н.В., Бобкова И.Н., Козловская Л.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Чеботарева Н.В., Бобкова И.Н., Козловская Л.В.</copyright-holder><copyright-holder xml:lang="en">Tchebotareva N.V., Bobkova I.N., Kozlovskaja L.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nephro.ru/jour/article/view/1524">https://journal.nephro.ru/jour/article/view/1524</self-uri><abstract><p>Прогрессирование хронических заболеваний почек с нарастанием почечной недостаточности, требующей заместительной почечной терапии на терминальной стадии, является одной из основных проблем в теоретической и практической нефрологии. Всестороннее изучение иммуновоспалительных механизмов поражения почек, в частности большого спектра провоспалительных и профиброгенных молекулярных медиаторов тканевого повреждения, позволило более детально представить значение процессов клеточной пролиферации, накопления и расщепления экстрацеллюлярного матрикса (ЭЦМ) в развитии фиброзно-склеротических изменений почечной ткани, особенно быстром при несостоятельности механизмов самозащиты почки (ингибиторов цитокинов, антиоксидантов, белков теплового шока и др.).</p></abstract><kwd-group xml:lang="ru"><kwd>хронический гломерулонефрит</kwd><kwd>интерстициальный фиброз</kwd><kwd>мочевые показатели</kwd><kwd>моноцитарный хемотаксический протеин-1 (МСР-1)</kwd><kwd>трансформирующий фактор роста - β1 (TGF-β1)</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Картамышева Н.Н., Чумакова О.В., Кучеренко А.Г., Сергеева Т.В. 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