nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-1531Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESI/D полиморфизм гена АПФ и Т174М полиморфизм гена ангиотензиногена при нефротическом синдроме у детейAngiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms and angiotensinogen (AGT) gene T174M polymorphisms in nephrotic syndrome in childrenШарноваЖ. П.SharnovaZh. P.noemail@neicon.ruЦыгинА. Н.TsyginA. N.noemail@neicon.ruТихомировЕ. Е.TikhomirovE. E.noemail@neicon.ruЦыгинаЕ. Н.TsyginaE. N.noemail@neicon.ruПинелисВ. Г.PinelisV. G.noemail@neicon.ruНаучный Центр Здоровья Детей РАМН г. МоскваRussian Federation200623062025816468Copyright © Шарнова Ж.П., Цыгин А.Н., Тихомиров Е.Е., Цыгина Е.Н., Пинелис В.Г., 20252025Шарнова Ж.П., Цыгин А.Н., Тихомиров Е.Е., Цыгина Е.Н., Пинелис В.Г.Sharnova Z.P., Tsygin A.N., Tikhomirov E.E., Tsygina E.N., Pinelis V.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/1531

Для исследования роли I/D полиморфизма гена АПФ и Т174М полиморфизма гена ангиотензиногена (АТГ) в развитии и прогрессировании нефротического синдрома (НС) у детей, мы определили генотип ангиотензин-превращающего фермента и ангиотензиногена у 80 русских детей с НС, включая 15 детей с ХПН. Частота генотипов достоверно не отличалась между нефротическими больными и контролем (n = 165). Распределение генотипов АПФ и АТГ было схожим среди больных с фокально-сегментарным гломерулосклерозом (n = 12), стероид-чувствительным нефротическим синдромом (n = 32), нефротическим синдромом с артериальной гипертензией (n = 22) и контролем. Преобладание DD генотипа АПФ было достоверно в группе больных с ХПН (47% vs 21%; c2 = 4,44; p < 0,05). Таким образом, DD генотип может служить фактором риска прогрессирования НС до стадии ХПН.

To investigate the impact of the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms and angiotensinogen (AGT) gene T174M polymorphisms on the prevalence and progression of nephrotic syndrom (NS) in children, we determined the ACE I/D genotype and AGT genotype in 80 Russian children with NS including 15 children with chronic renal failure (CRF). Genotype frequencies did not differ between patients with NS and controls (n = 165). The distribution of ACE and AGT genotypes was similar among NS subgroups, such as focal segmental glomerulosclerosis (FSGS) (n = 12), steroid-sensitive nephrotic syndrome (n = 32), nephrotic syndrome with hypertension (n = 22), and also it was no difference with control group. When NS subjects with CRF (n = 15) were compared to controls, the prevalence of ACE-DD genotype was significantly higher (47% vs 21%; c2 = 4,44; p < 0,05). Our results indicate that the DD genotype of ACE may be a risk factor for the dеvеlopment of progressive renal impairment in children with nephrotic syndrome.

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The authors declare that there are no conflicts of interest present.