References

nid

Нефрология и диализ

Nephrology and Dialysis

1680-44222618-9801

Российское диализное общество

nid-1551

Research Article

ОБЗОРЫ И ЛЕКЦИИ

REVIEWS AND LECTURES

Полиморфизм генов ренин-ангиотензин-альдостероновой системы при нефротическом синдроме у детей (Обзор литературы)

Renin-angiotensin-aldosterone system gene polymorphism in children with nephrotic syndrome Review

Шарнова

Ж. П.

Sharnova

Zh. P.

noemail@neicon.ru

Цыгин

А. Н.

Tsygin

A. N.

noemail@neicon.ru

Тихомиров

Е. Е.

Tikhomirov

E. E.

noemail@neicon.ru

НИИ педиатрии НЦЗД РАМН, г. МоскваRussian Federation

2006

23062025

83216224

2025

Шарнова Ж.П., Цыгин А.Н., Тихомиров Е.Е.

Sharnova Z.P., Tsygin A.N., Tikhomirov E.E.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.nephro.ru/jour/article/view/1551

Нефротический синдром (НС), объединяющий гетерогенную группу гломерулярных заболеваний, является одной из актуальных проблем детской нефрологии. Заболеваемость первичным НС составляет 2-13 случаев на 100 000 детей в возрасте до 10 лет [1]. Постоянное увеличение числа нефротических больных, прогрессирующих до стадии терминальной почечной недостаточности (ТПН) и нуждающихся в заместительной почечной терапии - лечении хроническим или перитонеальным диализом - или в трансплантации почки [2], убеждает в необходимости включения проблемы НС в список приоритетных исследований в нефрологии.

обзорнефротический синдромхроническая почечная недостаточностьполиморфизм геновренин-ангиотензин-альдостероновая система

References1

Баранов А.А. Клинические рекомендации по педиатрии. М., 2005: 107-112.

Игнатова М.С. Патология органов мочевой системы у детей (современные аспекты). Нефрология и диализ 2004; 6 (2): 127-131.

Камышова Е.С., Кутырина И.М., Носиков В.В., Швецов М.Ю. Значение полиморфных маркеров генов вазоактивных гормонов в оценке клинических особенностей хронического гломерулонефрита. Тер. архив 2005; 6: 16-20.

Кутырина И.М., Тареева И.Е., Носиков В.В. и соавт. Изучение полиморфизма гена ангиотензин-превращающего фермента при хроническом гломерулонефрите. Тер. архив 1999; 6: 30-34.

Кутырина М.И. Применение ингибиторов ангиотензин-превращающего фермента при первичных поражениях почек и диабетической нефропатии. Consilium Medicum 2002; 4 (7): 331-333.

Мустафина О.Е., Тхаркахова З.Н., Бикмеева А.М. и соавт. Полиморфизм гена ангиотензин-превращающего фермента и риск мультифакториальных заболеваний. Мед. генетика 2002; 1 (5): 212-220.

Мухин Н.А., Козловская Л.В., Кутырина И.М., Швецов М.Ю., Фомин В.В. Протеинурическое ремоделирование тубулоинтерстиция - мишень нефропротективной терапии при хронических заболеваниях почек. Тер. архив 2002; 6: 5-11.

Сивоус Г.И., Горашко Н.М., Носиков В.В., Касаткина Э.П. Влияние полиморфизма гена ангиотензин-превращающего фермента на антипротеинурический эффект ингибиторов АПФ и блокаторов рецепторов ангиотензина II типа 1 у молодых больных с диабетической нефропатией. Молекулярная медицина 2004; 1: 42-47.

Тареева И.Е., Кутырина И.М., Николаев А.Ю., Лифшиц Н.Л., Швецов М.Ю. Пути торможения развития хронической почечной недостаточности. Тер. архив 2000; 6: 9-14.

Шадрина М.И., Сломинский П.А., Милосердова О.В., Перова Н.В., Лимборская С.А. Анализ полиморфизма гена ангиотензин-превращающего фермента у больных ишемической болезнью сердца в московской популяции. Генетика 2001; 37 (4): 540-544.

Шулутко Б.И. Артериальная гипертензия. СПб.: РЕНКОР, 2001: 98-108.

Abbate M., Benigni A., Bertani T., Remuzzi G. Nephrotoxicity of increased glomerular protein traffic. Nephrol Dial Transplant 1999; 14: 304-312.

Al-Eisa A., Haider M.Z., Strivastva B.S. Angiotensin converting enzyme gene insertion/deletion polymorphism in idiopathic nephrotic syndrome in Kuwaiti Arab children. Scand J Urol Nephrol 2001; 35: 239-242.

Bantis C., Ivens K., Kreusser W., Koch M., Klein-Vehne N., Grabensee B., Heering P. Influence of genetic polymorphisms of renin-angiotensin system on IgA-nephropathy. Am J Nephrol 2004; 24 (2): 258-267.

Barley J., Blackwood A., Miller M. et al. Angiotensin converting enzime gene I/D-polymorphism, blood pressure and the renin-angiotensin system in Caucasian and Afro-Caribbean peoples. J Hum Hypertens 1996; 10 (1): 31-35.

Bonnardeaux A., Davies E., Jeunemaitre X., Fery I., Charru A., Clauser E., Tiret L., Cambien F., Corvol P., Soubrier F. Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension 1994; 24: 63-69.

Border W.F., Nobl N.A. Interaktions of transforming growth factor-β and angiotensin II in renal fibrosis. Hypertension 1998; 31: 181-188.

Buraczynka M., Grzebalska A.M., Spasiewicz D., Orlowska G., Ksiazek A. Genetic polymorphisms of renin-angiotensin system of interstitial nephritis. Ann Univ Mariae Curie Sclodowska (Med) 2002; 57 (2): 330-336.

Cameron J.S. Focal segmental glomerulosclerosis in adults. Nephrol Dial Transplant 2003; 18 (Suppl. 6): 45-51.

Caulfield M., Lavender P., Farral M. et al. Linkage of the angiotensinogen gene to essential hypertension. N Engl J Med 1994; 330: 1629-1633.

Dixit M., Mansur A., Dixin N., Gilman J., Santarina L., Glicklich D. The role of ACE gene polymorphism in rapidity of progression of focal segmental glomerulosclerosis. J Postgrad Med 2002; 48: 266-269.

Doria A., Warram J., Krolewski A. Molecular characterization of a DDEI melting polymorphism at the angiotensin I-converting enzime (ACE) locus. Hum Mutat 1994; 4 (2): 155-157.

Egido J. Vasoactive hormones and renal sclerоsis. Kidney Int 1996; 49: 578-597.

Fogo A. Progression and potential regression of glomerulosclerosis. Kidney Int 1993; 59: 804-819.

Frishberg Y., Becker-Cohen R., Halle D., Feigin E., Eisenstein B. et al. Genetic polymorfisms of the renin-angiotensin system and the outcome of focal segmental glomerulosclerosis in children. Kidney Int 1998; 54: 1843-1849.

Fujisawa T., Ikegami H., Kawaguchi Y. et al. Meta-analysis of association of insertion/deletion polymorphism of angiotensin I-converting enzyme gene with diabetic nephropathy and retinopathy. Diabetologia 1998; 41 (1): 47-53.

van Essen G.G., Rensma H.L., Zeeuw D., Sluiter W.J. et al. Association between angiotensin-converting-enzyme gene polymorphism and failure of renoprotective therapy. The Lancet 1996; 347: 94-95.

Gumprecht J., Zychma M.J., Grzeszczak W., Zukowska-Szczechowska E. and the End-Stage Renal Disease Study Group. Angiotensin I-converting enzyme gene insertion/deletion and angiotensinogen M235T-polymorphisms: Risk of chronic renal failure. Kidney Int 2000; 58: 513-519.

Hamaguchi et al. Abstract; J Soc Nephrol 1995; 6: 389.

Harden P.N., Geddes J.S. et al. Polymorphism angiotensin I-converting enzyme gene and progression of IgA-nephropathy. Lancet 1995; 342: 1540-1542.

Hegele R.A., Brunt J.H., Connely P.W. A polymorphism of the angiotensinogen gene associated with variation in blood pressure in genetic isolate. Circulation 1994; 90 (5): 2207-2212.

Hori C., Harioka M., Yoshikawa N., Tsuzuki K., Yohida Y., Yoshicka K., Fujisawa K., Tsukahara H., Ohshima Y., Mayumi M. Significance of ACE-genotypes and medical treatments in childhood focal glomerulosclerosis. Nephron 2001; 88: 313-319.

Hunley T.E., Julian B.A., Phillips J.A. et al. Angiotensin-converting enzyme gene polymorphism: potential silencer motif and impact on progression in IgA-nephropathy. Kidney Int 1996; 49: 571-577.

Ikoma M., Kawamura T., Kkinuma Y., Fogo A., Ichikawa I. Cause of variable therapeutic efficiency of angiotensin converting enzyme inhibitor on glomerular lesions. Kidney Int 1991; 40: 195-202.

Jacobsen P., Tarnow L., Carstensen B., Hovind P., Poirier O., Parving H. Genetic Variation in the Renin-Angiotensis System and Progression of Diabetic Nephropathy. J Am Soc Nephrol 2003; 14: 2843-2850.

Jafar T.H., Stark P.C., Schmid C. Proteinuria as a modifiable risk factor for the progression of non-diabetic renal disease. Kidney Int 2001; 60: 1131-1140.

Johnson R., Alpers C., Yoshimura A., Lombardi D. et al. Renal injury from angiotensin II-mediated hypertension. Hypertension 1992; 19: 464-474.

Klahr S., Schreiner G., Ichirawa I. The progression of renal disease. N Engl J Med 1988; 19: 464-474.

Krege J., John S., Langenbach L. et al. Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature 1995; 375: 146-148.

Lau Y.K., Woo K.T., Choong H.L. et al. ACE-gene polymorphism and disease progression of IgA-nephropathy in Asians in Singapore. Nephron 2002; 91: 499-503.

Lee Y., Tsai J. ACE-Gene Insertion/Deletion Polymorphism Associated With 1998 World Health Organization Definition of Metabolic Syndrome in Chinese Type 2 Diabеtic Patients. Diabetes Care 2002; 25: 1002-1008.

Lee K.B., Kim U.K. Angiotensinogen and angiotensin II type 1 receptor gene polymorphism in patients with autosomal dominant polycystic kidney disease: effect on hypertension and ESRD. Yonsei Med J 2003; 44 (4): 641-647.

Lee D.Y., Kim W., Kang S.K., Koh G.Y., Park S.K. Angiotensin-converting enzyme gene polymorphism in patients with minimal-change nephrotic syndrome and focal segmental glomerulosclerosis. Nephron 1997; 77: 471-473.

Ling H., Vamvakas S., Schaefer L., Schnittler H.J. Angiotensin II-induced cell hypertrophy: Potential role of impaired proteolytic activity in cultured LLC-PK1-cells. Nephrol Dial Transplant 1995; 10: 1305-1312.

Lovati E., Richard A., Frey B.M., Frey F.J., Ferrari P. Genetic polymorphisms of the renin-angiotensin-aldosterone system in end-stage renal disease. Kidney Int 2001; 60: 46-54.

Luther Y., Bantis C., Ivens K., Kolb-Bachhofen V., Heering P. Effects of genetic polymorphisms of the renin-angiotensin system on focal segmental glomerulosclerosis. Kidney Blood Press Res 2003; 26 (5-6): 333-337.

McLaughlin K.J.M., Harden P.N., Ueda S., Boulton-Jones J.M. et al. The role of genetic polymorphism of angiotensin-converting enzyme in the progression of renal diseases. Hypertension 1996; 28: 912-915.

Marian A.J. Genetic markers: genes involved in human hypertension. J Cardiovasc Risk 1997; 4 (5): 341-345.

Mizuiri S., Hemmi H., Inoue A. et al. Renal hemodynamic changes induced by captopril and angiotensin-converting enzyme gene polymorphism. Nephron 1997; 75: 310-314.

Maruyama K., Yoshida M., Nishio H., Shirakawa T., Kawamura T., Tanaka R., Nakamura H., Iiyima K., Yoshikawa N. Polymorphisms of renin-angiotensin system genes in childhood IgA-nephropathy. Pediatr Nephrol 2001; 16: 350-355.

Navis G., Van Der Kleij F.G., De Zeeuw D., De Jong P.E. Angiotensin-converting enzyme gene polymorphism has no influence on the circulating renin-angiotensin-aldosterone system or blood pressure in normotensive subjects. Circulation 1995; 91: 2933-2942.

Oktem F., Sirin A., Bilge I., Emre S., Agachan B., Turgau I. ACE I/D-gene polymorphism in primary FSGS and steroid-sensitive nephrotic syndrome. Pediatr Nephrol 2004; 19: 384-389.

Ong-Ajyooth S., Ong-Ajyooth L., Limmongkon A. et al. The renin-angiotensin system gene polymorphisms and clinicopathological correlation in IgA-nephropathy. J Med Assoc Thai 1999; 82 (7): 681-689.

Pardo R., Malaga S., Coto E., Navarro M., Alvarez V., Espinosa L., Alvarez R., Vallo A., Loris C., Braga S. Renin-angiotensin system polymorphisms and renal scarring. Pediatr Nephrol 2003; 18: 110-114.

Reggenenti P., Perna A., Mosconi L. et al. Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies. Ibid 1998; 53: 1209-1216.

Remuzzi G., Ruggenenti P., Benigni A. Pathophysiology of progressive nephropathies. Kidney Int 1997; 51: 2-15.

Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P., Soubrier F. An I/D-polymorphism in the ACE-gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343-1346.

Ruggenenti P., Perna F., Geradi G. Renal function and requirement for dialysis in chronic nephropathy patients in long-term ramipril: REIN follow-up trial. Lancet 1998; 352: 1252-1256.

Ruiz-Ortega M., Egido J. Angiotensin II modullates cell growth-related events and synthesis of matrix proteins in renal interstitial fibroblasts. Kidney Int 1997; 52: 1497-1510.

Ruiz-Ortega M., Lorenzo O., Suzuki Y., Ruperez M., Egido J. Proinflammatory actions of angiotensin II. Curr Opin Nephrol Hypertens 2001; 10: 321-329.

Rutledge D.R., Browe C.S., Kubilis P.S., Ross E.A. Analysis of two variants of the angiotensinogen gene in essential hypertensive African-Americans. Am J Hypertens 1994; 7: 651-654.

Schena F.P., D’Altri C., Cerullo G. et al. ACE-gene polymorphism and IgA-nephropathy: An ethnically homogeneous study and a meta-analysis. Kidney Int 2001; 60: 732-740.

Schieppati А. and Remuzzi G. The future of renoprotection: frustration and promises. Kidney Int 2003; 64: 1947-1955.

Schmidt S., Ritz E. The role of I-converting enzyme gene polymorphism in renal disease. Curr Opin Nephrol Hypertens 1996; 5: 552-555.

Schmidt S., van Hooft I.M.S., Grobbe D.E. et al. Polymorphism of the angiotensin I converting enzyme gene and its predisposition to high blood pressure. Hypertension 1993; 21: 455-460.

Schmidt S., Sharma A.M., Zilch O., Beige J., Walla-Friedel M., Ganten D., Distler A., Ritz E. Association of M235T-variant of the angiotensinogen gene with familial hypertension of early onset. Nephrol Dial Transplant 1995; 10: 1145-1148.

Serdaroglu E., Mir S., Berdeli A., Aksu N., Bak M. ACE-gene insertion/deletion polymorphism in childhood idiopathic nephrotic syndrome. Pediatr Nephrol 2005; 20: 1738-1743.

Song J., Narita I., Goto S. et al. Gender specific association of aldosterone sinthase gene polymorphism with renal survival in patientes with IgA-nephropaty. J Med Genet 2003; 40: 372-376.

Stratta P., Canavese C., Ciccone G. et al. Angiotensin I-converting enzyme genotype significantly affects progression of IgA-glomerulonephritis in an Italian population. Am J Kidney Dis 1999; 33 (6): 1071-1079.

Wolf G., Ziyadeh F.N., Zahner G., Stahl R.A.K. Angiotensin II is mitogenic for cultured rat glomerular endothelial cells. Hypertension 1996; 27: 897-905.

Wolf G. Angiotensin II is involved in the progression of renal disease: importence of non-hemodinamic mechanisms. Nephrologie 1998; 19: 451-456.

Wolf G., Haberstroh U., Neilson E.G. Angiotensin II stimulates the proliferation and biosynthesis of type I collagen in cultured murine mesangial cells. Am J Pathil 1992; 140: 95-107.

Wolf G., Neilson E.G. Angiotensin II as renal growth factor. J Am Soc Nephrol 1993; 3: 1531-1540.

Wolf G., Neilson E.G. Angiotensin II induces cellular hypertrophy in cultured murine proximal tubular cells. Am J Physiol 1990; 259: 768-777.

Woo K.T., Lau Y.K., Choong L.H., Tan H.B., Fook-Chong S., Tan E.K., Yap H.K., Wong KS. Polymorphisms of renin-angiotensin system genes in IgA-nephropathy. Nephrology (Carlton) 2004; 9 (5): 304-309.

Yorioka T., Suihiro T. et al. Polymorphism of the angiotensin-converting enzyme gene and clinical aspect of IgA-nephropathy. Clin Nephrol 1995; 44: 80-85.

Yoshida H., Mitarai T., Kawamura T., Kitajima T., Miyazaki Y., Nagasawa R., Kawaguchi Y., Kubo H., Ichikawa I., Sakai O. Role of the deletion polymorphism of the angiotensin-converting enzyme gene in the progression and therapeutic responsiveness of IgA-nephropathy. J Clin Invest 1995; 96: 2162-2169.

The authors declare that there are no conflicts of interest present.