nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-1564Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESЗначение малобелковой диеты в замедлении прогрессирования хронической почечной недостаточностиInfluence of low protein diet on progression of chronic renal failureЕрмоленкоВ. М.ErmolenkoV. M.noemail@neicon.ruКозловаТ. А.KozlovaT. A.noemail@neicon.ruМихайловаН. А.MichailovaN. A.noemail@neicon.ruРМАПО, г. МоскваRussian Federation20062306202584310320Copyright © Ермоленко В.М., Козлова Т.А., Михайлова Н.А., 20252025Ермоленко В.М., Козлова Т.А., Михайлова Н.А.Ermolenko V.M., Kozlova T.A., Michailova N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/1564

Еще в 1869 г. L. Beale [23] писал, что ограничение потребления белка облегчает состояние больных с нарушенной функцией почек, а F. Volhard [154] указывал, что у больных с хронической почечной недостаточностью (ХПН) «возможно отсрочить» повышение концентрации мочевины в крови на длительный период времени, уменьшая потребление азота до 3-5 г/сут (20-30 г/сут белка). В ряде случаев ему удавалось, ограничивая потребление белка, снизить высокий уровень мочевины в крови, что сопровождалось исчезновением симптомов уремии. L. Ambard, известный своими работами в области физиологии и патофизиологии почек, в 1909 г. предложил определять «дебит мочевины» - произведение концентрации мочевины на диурез в соотношении к уровню мочевины в крови. В норме константа Ambard равнялась 0,07, а ее увеличение характеризовало степень нарушения функции почек. Двумя годами позднее он отмечал, что больные с уремией часто выглядят истощенными и усугубляют свое состояние, если употребляют в пищу мясо [5].

роническая почечная недостаточностьмалобелковая диетакетоаналоги аминокислотReferencesБереснева О.Н., Парастаева М.М., Иванова Г.Т. и соавт. Роль кетостерила в нефропротекции и кардиопротекции при экспериментальной уремии. Нефрология 2006; 1: 56-62.Береснева О.Н., Парастаева М.М., Иванова Г.Т. и соавт. Роль кетостерила в нефропротекции и кардиопротекции при экспериментальной уремии. Нефрология 2006; 1: 56-62.Тареева И.Е., Кутырина И.М., Николаев А.Ю. и др. Пути торможения развития хронической почечной недостаточности. Тер. архив 2000; 6: 9-14.Тареева И.Е., Кутырина И.М., Николаев А.Ю. и др. Пути торможения развития хронической почечной недостаточности. Тер. архив 2000; 6: 9-14.Чеботарева Н.В. Бобкова И.Н., Козловская Л.В. Молекулярные механизмы интерстициального фиброза при прогрессирующих заболеваниях почек. Нефрология и диализ 2006; 1: 26-36.Чеботарева Н.В. Бобкова И.Н., Козловская Л.В. Молекулярные механизмы интерстициального фиброза при прогрессирующих заболеваниях почек. Нефрология и диализ 2006; 1: 26-36.Agus D., Mann R., Cohn D. et al. Inhibitory role of dietary protein restriction on the development and expression of immune mediated antitubular basement membrano-induced tubulointerstitial nephritis in rats. J Clin Investig 1985; 76: 930-936.Agus D., Mann R., Cohn D. et al. Inhibitory role of dietary protein restriction on the development and expression of immune mediated antitubular basement membrano-induced tubulointerstitial nephritis in rats. J Clin Investig 1985; 76: 930-936.Ambard L. Physiologie Normale et Phathologie des Reins. Paris, Masson et Cie 1920: 264.Ambard L. Physiologie Normale et Phathologie des Reins. Paris, Masson et Cie 1920: 264.Aparicio M., Potaux L., Precigout V. et al. Hypertriglyceridemia and low-phosphorus, low-nitrogen diet in patient with chronic renal failure. Nephron 1987; 46: 335-336.Aparicio M., Potaux L., Precigout V. et al. Hypertriglyceridemia and low-phosphorus, low-nitrogen diet in patient with chronic renal failure. Nephron 1987; 46: 335-336.Aparicio M., Bouchet J., Gin H. et al. Effect of a low-protein diet on urinary albumin excretion in uremic patients. Nephron 1988; 50: 288-291.Aparicio M., Bouchet J., Gin H. et al. Effect of a low-protein diet on urinary albumin excretion in uremic patients. Nephron 1988; 50: 288-291.Aparicio M., Vincendeau Ph., Gin H. et al. Effect of a low-protein diet on chemiluminescence production by leukocytes from uremic patients. Nephron 1988; 48: 315-318.Aparicio M., Vincendeau Ph., Gin H. et al. Effect of a low-protein diet on chemiluminescence production by leukocytes from uremic patients. Nephron 1988; 48: 315-318.Aparicio M., Gin H., Potaux L. et al. Effect of ketoacid diet on glucose tolerance and tissue insulin sensitivity. Kidney int 1989; 36; Suppl. 27: 231-235.Aparicio M., Gin H., Potaux L. et al. Effect of ketoacid diet on glucose tolerance and tissue insulin sensitivity. Kidney int 1989; 36; Suppl. 27: 231-235.Aparicio M., Gin H., de Precigout V. et al. Complaince with low protein diet by uremic patients: three years' experience. Contrib Nephrol 1990; 81: 71-78.Aparicio M., Gin H., de Precigout V. et al. Complaince with low protein diet by uremic patients: three years' experience. Contrib Nephrol 1990; 81: 71-78.Aparicio M., Lafage M.H., Combe C. et al. Low-protein diet and renal osteodystrophy. Nephron 1991; 58: 250-252.Aparicio M., Lafage M.H., Combe C. et al. Low-protein diet and renal osteodystrophy. Nephron 1991; 58: 250-252.Aparicio M., Lafage M.H., Combe C. и cоавт. Метаболические эффекты низкобелковой низкофосфорной диеты у больных с хронической почечной недостаточностью. Клин. фармакол. тер. 1996; 2: 15-18.Aparicio M., Lafage M.H., Combe C. и cоавт. Метаболические эффекты низкобелковой низкофосфорной диеты у больных с хронической почечной недостаточностью. Клин. фармакол. тер. 1996; 2: 15-18.Avram M., Shreedhara R. Fein P. et al. Survival on hemodialysis and peritoneal dialysis over 12 years with emphasis on nutritional parameters. Am J Kidney Dis 2001; 37: S77-S80.Avram M., Shreedhara R. Fein P. et al. Survival on hemodialysis and peritoneal dialysis over 12 years with emphasis on nutritional parameters. Am J Kidney Dis 2001; 37: S77-S80.Arai J., Hara Y., Fukuda S. et al. Metabolic conversion of a-keto valine to valine in patients with chronic renal failure. Clin Nephrol 1985; 23: 236-240.Arai J., Hara Y., Fukuda S. et al. Metabolic conversion of a-keto valine to valine in patients with chronic renal failure. Clin Nephrol 1985; 23: 236-240.Barrientos A., Arteaga J., Rodicio L. et al. Role of the control of phosphate in the progression of chronic renal failure. Mineral Electrolyte Metab 1982; 7: 127-133.Barrientos A., Arteaga J., Rodicio L. et al. Role of the control of phosphate in the progression of chronic renal failure. Mineral Electrolyte Metab 1982; 7: 127-133.Barsotti G., Morelli E., Guiducci A. et al. Reversal of hyperparathyroidism in severe uremics following very low-protein and low-phosphorus diet. Nephron 1982; 30: 310-313.Barsotti G., Morelli E., Guiducci A. et al. Reversal of hyperparathyroidism in severe uremics following very low-protein and low-phosphorus diet. Nephron 1982; 30: 310-313.Barsotti G., Morelli E., Cupisti A. et al. Restricted phosphorus and nitrogen intake to slow the progression of chronic renal failure: a controlled trial. Kidney int 1983; 24; Suppl. 16: 278-284.Barsotti G., Morelli E., Cupisti A. et al. Restricted phosphorus and nitrogen intake to slow the progression of chronic renal failure: a controlled trial. Kidney int 1983; 24; Suppl. 16: 278-284.Barsotti G., Gainnoni A., Morelli E. et al. The decline of renal function slowed by very low phosphorus intake in chronic renal patients following a low nitrogen diet. Clin Nephrol 1984; 21: 54-59.Barsotti G., Gainnoni A., Morelli E. et al. The decline of renal function slowed by very low phosphorus intake in chronic renal patients following a low nitrogen diet. Clin Nephrol 1984; 21: 54-59.Barsotti G., Cristofano C., Morelli E. et al. Serum oxalis acid in uremia: effect of a low-protein diet supplemented with essential amino acids and ketoanalogues. Nephron 1984; 38: 54-56.Barsotti G., Cristofano C., Morelli E. et al. Serum oxalis acid in uremia: effect of a low-protein diet supplemented with essential amino acids and ketoanalogues. Nephron 1984; 38: 54-56.Barsotti G., Ciardella F., Morelli E. et al. Restoration of blood levels of testosterone in male uremics following a low-protein diet supplemented with essential amino acids and ketoanalogues. Contr Nephrol 1985; 49: 63-69.Barsotti G., Ciardella F., Morelli E. et al. Restoration of blood levels of testosterone in male uremics following a low-protein diet supplemented with essential amino acids and ketoanalogues. Contr Nephrol 1985; 49: 63-69.Barsotti G., Ciardella F., Morelli E. et al. Nutritional treatment of renal failure in type 1 diabetic nephropathy. Clin Nephrol 1988; 29: 280-287.Barsotti G., Ciardella F., Morelli E. et al. Nutritional treatment of renal failure in type 1 diabetic nephropathy. Clin Nephrol 1988; 29: 280-287.Barsotti G., Moriconi L., Cupisti A. et al. Protection of renal function and nutritional status in uraemic rats by means of a low-protein, low-phosphorus supplemented diet. Nephron 1988; 49: 197-202.Barsotti G., Moriconi L., Cupisti A. et al. Protection of renal function and nutritional status in uraemic rats by means of a low-protein, low-phosphorus supplemented diet. Nephron 1988; 49: 197-202.Beale L. Kidney diseases, urinary deposits and calculous disorders. Their nature and treatment. Philadelphia, -Lindsay and Blakiston 1869.Beale L. Kidney diseases, urinary deposits and calculous disorders. Their nature and treatment. Philadelphia, -Lindsay and Blakiston 1869.Beddhu S., Samore M., Roberts M. et al. Impact of initiation of dialysis on mortality. J Am Soc Nephrol 2003; 14: 2305-2312.Beddhu S., Samore M., Roberts M. et al. Impact of initiation of dialysis on mortality. J Am Soc Nephrol 2003; 14: 2305-2312.Bending J., Dodds R., Keen H. et al. Renal response to restriction protein intake in diabetic nephropathy. Diabetologia 1988; 3: 1641-1646.Bending J., Dodds R., Keen H. et al. Renal response to restriction protein intake in diabetic nephropathy. Diabetologia 1988; 3: 1641-1646.Bеrgesio F., Monzani G., Guasparini A. et al. Cardiovascular risk factors in severe chronic renal failure: the role of dietary treatment. Clin Nephrol 2005; 64: 103-112.Bеrgesio F., Monzani G., Guasparini A. et al. Cardiovascular risk factors in severe chronic renal failure: the role of dietary treatment. Clin Nephrol 2005; 64: 103-112.Berlyne G., Shaw A., Nilwarngkur S. Dietary treatment of chronic renal failure. Experience with modified Giovannetti diet. Nephron 1965; 2: 129-147.Berlyne G., Shaw A., Nilwarngkur S. Dietary treatment of chronic renal failure. Experience with modified Giovannetti diet. Nephron 1965; 2: 129-147.Bernard S., Fongue D., Laville M., Zech P. Effects of low protein diet supplemented with ketoacids on plasma lipids in adult chronic renal failure. Miner Electrolite Metab 1996; 22: 143-146.Bernard S., Fongue D., Laville M., Zech P. Effects of low protein diet supplemented with ketoacids on plasma lipids in adult chronic renal failure. Miner Electrolite Metab 1996; 22: 143-146.Blumenkrantz M., Kopple J. VA cooperative dialysis study participants: incidence of nutritional abnormalities in uremic patients entering dialysis therapy. Kidney int 1976; 10: 514.Blumenkrantz M., Kopple J. VA cooperative dialysis study participants: incidence of nutritional abnormalities in uremic patients entering dialysis therapy. Kidney int 1976; 10: 514.Bonomini V., Felleti C., Scolary M., Stefani S. Benefits of early initiation of dialysis. Kidney int 1985; 28 (Suppl. 17): S57-S59.Bonomini V., Felleti C., Scolary M., Stefani S. Benefits of early initiation of dialysis. Kidney int 1985; 28 (Suppl. 17): S57-S59.Bradford J. The results following partial nephrectomy and the influence of the kidney metabolism. J Physiol 1899; 23: 415.Bradford J. The results following partial nephrectomy and the influence of the kidney metabolism. J Physiol 1899; 23: 415.Brenner B., Meyer T., Hostetter T. Dietary protein intake and the progressive nature of kidney disease: the role hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation and intrinsic renal disease. N Engl J Med 1982; 307: 652-659.Brenner B., Meyer T., Hostetter T. Dietary protein intake and the progressive nature of kidney disease: the role hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation and intrinsic renal disease. N Engl J Med 1982; 307: 652-659.Brenner B. Hemodynamically mediated glomerular injury and the progressive nature of renal disease. Kidney int 1983; 23: 647-655.Brenner B. Hemodynamically mediated glomerular injury and the progressive nature of renal disease. Kidney int 1983; 23: 647-655.Brenner B. Nephron adaptation to renal injuri or ablation. Am J Physiol 1985; 249: F324.Brenner B. Nephron adaptation to renal injuri or ablation. Am J Physiol 1985; 249: F324.Chade A., Lerman A., Lerman L. Kidney in early atherosclerosis. Hypertension 2005; 45: 1042-1049.Chade A., Lerman A., Lerman L. Kidney in early atherosclerosis. Hypertension 2005; 45: 1042-1049.Chanutin A., Ferris E. Experimental renal insufficiency produced by partial nephrectomy. I Control diet. Arch int Med 1936; 58: 60.Chanutin A., Ferris E. Experimental renal insufficiency produced by partial nephrectomy. I Control diet. Arch int Med 1936; 58: 60.Chauveau Ph., Lebkiri B., Ployard F. et al. Effect des cetoanalogues des acides amines essentials sur la progression de l'insuffisance renale chronique avancee: etude prospective controlee. Nephrologie 1986; 4: 137-142.Chauveau Ph., Lebkiri B., Ployard F. et al. Effect des cetoanalogues des acides amines essentials sur la progression de l'insuffisance renale chronique avancee: etude prospective controlee. Nephrologie 1986; 4: 137-142.Churchull D. An evidence-based approach to earlier initiation of dialysis. Am J Kidney Dis 1997; 30: 899-906.Churchull D. An evidence-based approach to earlier initiation of dialysis. Am J Kidney Dis 1997; 30: 899-906.Ciardella F., Morelli E. Niosi F. et al. Effect of a low-phosphorus, low nitrogen diet supplemented with essential amino acids and ketoanalogues on serum triglycerides of chronic uremic patients. Nephron 1986; 42: 196-199.Ciardella F., Morelli E. Niosi F. et al. Effect of a low-phosphorus, low nitrogen diet supplemented with essential amino acids and ketoanalogues on serum triglycerides of chronic uremic patients. Nephron 1986; 42: 196-199.Ciardella F., Morelli E., Cupisti A. et al. Metabolic effects of very low protein low phosphorus diet supplemented with essential amino acids and ketoanaloges in end-stage renal diseases. Contr Nephrol 1988; 65: 72-88.Ciardella F., Morelli E., Cupisti A. et al. Metabolic effects of very low protein low phosphorus diet supplemented with essential amino acids and ketoanaloges in end-stage renal diseases. Contr Nephrol 1988; 65: 72-88.Claris-Appiani A., Assael B., Tirelli A. Lack of glomerular hemodynamic stimulation after infusion of branched-chain amino acids. Kidney int 1988; 33: 91-94.Claris-Appiani A., Assael B., Tirelli A. Lack of glomerular hemodynamic stimulation after infusion of branched-chain amino acids. Kidney int 1988; 33: 91-94.Cohen D., Dodds R., Viberti G. Effect protein restriction in insulin dependent diabetics at risk of nephropathy. Br Med J 1987; 294: 795-798.Cohen D., Dodds R., Viberti G. Effect protein restriction in insulin dependent diabetics at risk of nephropathy. Br Med J 1987; 294: 795-798.Coresh J., Walser M., Hill S. Survival on dialysis among chronic renal failure patients treated with a supplemented low-protein diet before dialysis. J Am Soc Nephrol 1995; 6: 1379-1385.Coresh J., Walser M., Hill S. Survival on dialysis among chronic renal failure patients treated with a supplemented low-protein diet before dialysis. J Am Soc Nephrol 1995; 6: 1379-1385.Corman B., Chami-Khazraji S., Schaeverbeke J., Michel J. Effect of feeding on glomerular filtration in conscious aging rats. Am J Physiol 1988; 255: F250-F256.Corman B., Chami-Khazraji S., Schaeverbeke J., Michel J. Effect of feeding on glomerular filtration in conscious aging rats. Am J Physiol 1988; 255: F250-F256.Cupisti A., Carulli G., Polidori R. et al. Superoxide anion prodution and dietary treatment in chronic renal failure. Nephron 1991; 57: 119-120.Cupisti A., Carulli G., Polidori R. et al. Superoxide anion prodution and dietary treatment in chronic renal failure. Nephron 1991; 57: 119-120.Di Iorio B., Minutolo R., De Nicola L. et al. Supplemented very low protein diet ameliorates responsiveness to erythropoietin in chronic renal failure. Kidney int 2003; 64: 1822-1828.Di Iorio B., Minutolo R., De Nicola L. et al. Supplemented very low protein diet ameliorates responsiveness to erythropoietin in chronic renal failure. Kidney int 2003; 64: 1822-1828.El-Nahas A., Masters-Thomas A., Brady S. et al. Selective of low protein diet in chronic renal diseases. Brit Med J 1984; 289:1337-1341.El-Nahas A., Masters-Thomas A., Brady S. et al. Selective of low protein diet in chronic renal diseases. Brit Med J 1984; 289:1337-1341.Evanoff G., Thompson C., Brown J. et al. The effect of protein restriction on the progression diabetic nephropathy. A 12-month follow-up. Arch int Med 1987; 147: 492-495.Evanoff G., Thompson C., Brown J. et al. The effect of protein restriction on the progression diabetic nephropathy. A 12-month follow-up. Arch int Med 1987; 147: 492-495.Fera H. Fünf Sprachen unter einem Hut (Verlage für Volkstum, Berlin: 1939).Fera H. Fünf Sprachen unter einem Hut (Verlage für Volkstum, Berlin: 1939).Fioretti P., Melis G., Ciardella F. et al. Parathyreoid function and pituitary-gonadal axis in male uremics; effects of dietary treatment and of maintenance hemodialysis. Clin Nephrol 1986; 25: 155-158.Fioretti P., Melis G., Ciardella F. et al. Parathyreoid function and pituitary-gonadal axis in male uremics; effects of dietary treatment and of maintenance hemodialysis. Clin Nephrol 1986; 25: 155-158.Fouque D., Wang P., Laville M. et al. Low protein diets delay end-stage renal disease in non-diabetic adults with chronic renal failure. Nephrol Dial Trasplant 2000; 15: 1986-1992.Fouque D., Wang P., Laville M. et al. Low protein diets delay end-stage renal disease in non-diabetic adults with chronic renal failure. Nephrol Dial Trasplant 2000; 15: 1986-1992.Fröhling P., Kokot F., Schmicker R. et al. Influence of ketoacids on serum parathyroid hormone levels in patients with chronic renal failure. Clin Nephrol 1983; 20: 212-215.Fröhling P., Kokot F., Schmicker R. et al. Influence of ketoacids on serum parathyroid hormone levels in patients with chronic renal failure. Clin Nephrol 1983; 20: 212-215.Fröhling P., Schmidt-Gayk H., Kokot F. et al. Influence of vitamin D and keto acids (KA) on 1,25(OH)2D levels in patient with chronic renal failure. Vitamin D: Chem Biochem and Clin Update. Proc 6th workshop. Merano, Berlin, 17-22 March, 1985: 952-953.Fröhling P., Schmidt-Gayk H., Kokot F. et al. Influence of vitamin D and keto acids (KA) on 1,25(OH)2D levels in patient with chronic renal failure. Vitamin D: Chem Biochem and Clin Update. Proc 6th workshop. Merano, Berlin, 17-22 March, 1985: 952-953.Fröhling P., Krupki F., Kokot F. et al. What are the most important factors in the progression of renal failure? Kidney int 1989; 36; Suppl. 27: S106-S109.Fröhling P., Krupki F., Kokot F. et al. What are the most important factors in the progression of renal failure? Kidney int 1989; 36; Suppl. 27: S106-S109.Garibotto Q., Russo R., Sifia A. et al. Skeletal muscle protein synthesis and degradation in patients with chronic renal failure. Kidney int 1994; 45: 1432-1439.Garibotto Q., Russo R., Sifia A. et al. Skeletal muscle protein synthesis and degradation in patients with chronic renal failure. Kidney int 1994; 45: 1432-1439.Gin H., Aparicio M., Potaux L. et al. Low-protein and low phosphorus diet in patients with chronic renal failure: influence on glucose tolerance and tissue insulin sensitivity. Metabolism 1987; 36: 1080-1085.Gin H., Aparicio M., Potaux L. et al. Low-protein and low phosphorus diet in patients with chronic renal failure: influence on glucose tolerance and tissue insulin sensitivity. Metabolism 1987; 36: 1080-1085.Gin H., Aparicio M., Potaux L. et al. Low-protein, low-phosphorus diet and tissue insulin sensitivity in insulin-dependent diabetic patients with chronic renal failure. Nephron 1991; 57: 411-415.Gin H., Aparicio M., Potaux L. et al. Low-protein, low-phosphorus diet and tissue insulin sensitivity in insulin-dependent diabetic patients with chronic renal failure. Nephron 1991; 57: 411-415.Gin H., Combe C., Rigallean V. et al. Effects of low-protein, low-phosphorus diet on metabolic insulin clearance in patients with chronic renal failure. Am J Clin Nutr 1994; 59: 663-666.Gin H., Combe C., Rigallean V. et al. Effects of low-protein, low-phosphorus diet on metabolic insulin clearance in patients with chronic renal failure. Am J Clin Nutr 1994; 59: 663-666.Giordano C. The use of exogenous and endogenous urea for protein in normal and uremic subjects. J Lab Clin Med 1963; 62: 231.Giordano C. The use of exogenous and endogenous urea for protein in normal and uremic subjects. J Lab Clin Med 1963; 62: 231.Giovanetti S., Maggiore Q. A low nitrogen diet with proteins of high biological value for severe chronic uremia. Lancet 1964; 1: 1000-1003.Giovanetti S., Maggiore Q. A low nitrogen diet with proteins of high biological value for severe chronic uremia. Lancet 1964; 1: 1000-1003.Giovanetti S. Unwanted side effects of nutritional therapy for patients with chronic renal failure. In book: Nutritional treatment of chronic renal failure. Oxford: Kluwer 1989: 267.Giovanetti S. Unwanted side effects of nutritional therapy for patients with chronic renal failure. In book: Nutritional treatment of chronic renal failure. Oxford: Kluwer 1989: 267.Glasser R., Velosa J., Michael A. Experimental model of focal sclerosis. Lab Investing 1977; 36: 519-526.Glasser R., Velosa J., Michael A. Experimental model of focal sclerosis. Lab Investing 1977; 36: 519-526.Graham K., Reaich D., Channon S. et al. Correction acidosis in CAPD decrease whole body protein degradation. Kidney int 1996; 49: 1396-1400.Graham K., Reaich D., Channon S. et al. Correction acidosis in CAPD decrease whole body protein degradation. Kidney int 1996; 49: 1396-1400.Grützmacher P., März W., Peschke B. et al. Lipoproteins and apolipoproteins during progression of chronic renal disease. Nephron 1988; 50: 103-111.Grützmacher P., März W., Peschke B. et al. Lipoproteins and apolipoproteins during progression of chronic renal disease. Nephron 1988; 50: 103-111.Goodship T., Mitch W., Hoerr R.A. et al. Adaption to low protein diets in renal failure: turnover and nitrogen balance. J Am Soc Nephrol 1990; 3: 66-75.Goodship T., Mitch W., Hoerr R.A. et al. Adaption to low protein diets in renal failure: turnover and nitrogen balance. J Am Soc Nephrol 1990; 3: 66-75.Haeberie K. Physiological aspects of low protein diet therapy. Blood Purif 1989; 7: 32-42.Haeberie K. Physiological aspects of low protein diet therapy. Blood Purif 1989; 7: 32-42.Hakim R., Lazarus J. Initiation of dialysis. J Am Soc Nephrol 1998; 9: 596-599.Hakim R., Lazarus J. Initiation of dialysis. J Am Soc Nephrol 1998; 9: 596-599.Halliburton J., Thomson R. Clinical aspects of compensatory renal hypertrophy. Cancer Res 1965; 25: 1882-1887.Halliburton J., Thomson R. Clinical aspects of compensatory renal hypertrophy. Cancer Res 1965; 25: 1882-1887.Hansen H., Tauber-Lassen B., Jensen B. et al. Effect of dietary protein restriction on prognosis in patients with diabetic nephropathy. Kidney int 2002; 62: 220-228.Hansen H., Tauber-Lassen B., Jensen B. et al. Effect of dietary protein restriction on prognosis in patients with diabetic nephropathy. Kidney int 2002; 62: 220-228.Hara Y., May R., Kelly R., Mitch W. Acidosis, not azotemia stimulates branched-chain amino acid catabolism in uremic rats. Kidney int 1987; 32: 808-814.Hara Y., May R., Kelly R., Mitch W. Acidosis, not azotemia stimulates branched-chain amino acid catabolism in uremic rats. Kidney int 1987; 32: 808-814.Harris D., Chan L., Schrier R. Remnant kidney hypermetabolism and progression of chronic renal failure. AmJ. Physiol 1988; 254: F267-F276.Harris D., Chan L., Schrier R. Remnant kidney hypermetabolism and progression of chronic renal failure. AmJ. Physiol 1988; 254: F267-F276.Haut L., Alfrey A., Guggenheim S. et al. Renal toxicity of phosphate in rats. Kidney int 1980; 17: 722-731.Haut L., Alfrey A., Guggenheim S. et al. Renal toxicity of phosphate in rats. Kidney int 1980; 17: 722-731.Heidland A., Kult J. Long-term effects of essential amino acid supplemention in patients on regular dialysis treatment. Clin Nephrol 1975; 3: 235-239.Heidland A., Kult J. Long-term effects of essential amino acid supplemention in patients on regular dialysis treatment. Clin Nephrol 1975; 3: 235-239.Heifets M., Morrissey J., Purkerson M. et al. Effect of dietary lipids on renal function in rats with subtotal nephrectomy. Kidney int 1989; 35: 40-47.Heifets M., Morrissey J., Purkerson M. et al. Effect of dietary lipids on renal function in rats with subtotal nephrectomy. Kidney int 1989; 35: 40-47.Hirschberg R., Cohen A., Kopple J. Effects of keto acid supplements on renal function and histology in azotemic rats fed high-protein diets. Am J Nephrol 1988; 8: 50-55.Hirschberg R., Cohen A., Kopple J. Effects of keto acid supplements on renal function and histology in azotemic rats fed high-protein diets. Am J Nephrol 1988; 8: 50-55.Ibels L., Alfrey A., Haut L. et al. Preservation of function in experimental renal disease by dietary restriction of phosphate. N Engl J Med 1978; 298: 122-126.Ibels L., Alfrey A., Haut L. et al. Preservation of function in experimental renal disease by dietary restriction of phosphate. N Engl J Med 1978; 298: 122-126.Ihle B., Becker G., Whitworth J., Charlwood R., Kincaid-Smith P. The effect of protein restriction on the progression of renal insufficiency. N Engl J Med 1989; 321: 1773-1777.Ihle B., Becker G., Whitworth J., Charlwood R., Kincaid-Smith P. The effect of protein restriction on the progression of renal insufficiency. N Engl J Med 1989; 321: 1773-1777.Ikizler T., Green J., Wingard R. et al. Spontaneous dietary intake during progression of chronic renal failure. J Am Soc Nephrol 1995; 6: 1386-1391.Ikizler T., Green J., Wingard R. et al. Spontaneous dietary intake during progression of chronic renal failure. J Am Soc Nephrol 1995; 6: 1386-1391.Ikizler T., Pupim L., Bronilette J. et al. Hemodialysis stimulate muscle and whole body protein loss and alters substrate oxidation. Am Physiol Endocrinol Metab 2002; 282: E107-116.Ikizler T., Pupim L., Bronilette J. et al. Hemodialysis stimulate muscle and whole body protein loss and alters substrate oxidation. Am Physiol Endocrinol Metab 2002; 282: E107-116.Ingale A., Ingale F., Kulkarni H. Unexpected rise in GFR in a patient of chronic kidney disease with single functioning kidney following keto-diet: a case report. Am J Nephrol 2004; 24: 61.Ingale A., Ingale F., Kulkarni H. Unexpected rise in GFR in a patient of chronic kidney disease with single functioning kidney following keto-diet: a case report. Am J Nephrol 2004; 24: 61.Ishikava I., Purkerson M., Klahr S. et al. Mechanism of reduced glomerular filtration rats in chronic malnutrition. J Clin Investig 1980; 65: 982-988.Ishikava I., Purkerson M., Klahr S. et al. Mechanism of reduced glomerular filtration rats in chronic malnutrition. J Clin Investig 1980; 65: 982-988.Ishikava I., Purkerson M., Yates J., Klahr S. Dietary protein intake conditions the degree of renal vasoconstriction in acute renal failure caused by ureteral obstruction. Am J Physiol 1985; 249: F54-F57.Ishikava I., Purkerson M., Yates J., Klahr S. Dietary protein intake conditions the degree of renal vasoconstriction in acute renal failure caused by ureteral obstruction. Am J Physiol 1985; 249: F54-F57.Jones M., Kopple J. Valine metabolism in normal and chronically uremic man. Am J Clin Nutr 1978; 31: 1660-1664.Jones M., Kopple J. Valine metabolism in normal and chronically uremic man. Am J Clin Nutr 1978; 31: 1660-1664.Jungers P., Chauveau Ph., Ployard F. et al. Comparison of ketoacids and low protein diet on advanced chronic renal failure progression. Kidney int 1987; 32; Suppl. 22: S67-S71.Jungers P., Chauveau Ph., Ployard F. et al. Comparison of ketoacids and low protein diet on advanced chronic renal failure progression. Kidney int 1987; 32; Suppl. 22: S67-S71.Kaysen G. Hyperlipidemia of chronic renal failure. Blood Purif 1994; 12: 60-67.Kaysen G. Hyperlipidemia of chronic renal failure. Blood Purif 1994; 12: 60-67.Kasiske B., Lakatna J., Ma J., Louis T. A meta-analysis of the effects of dietary protein restriction on the rate of decline in renal function. Am J Kidney Dis 1998; 31: 954-961.Kasiske B., Lakatna J., Ma J., Louis T. A meta-analysis of the effects of dietary protein restriction on the rate of decline in renal function. Am J Kidney Dis 1998; 31: 954-961.Keane W., Kasiske B., O'Donell M. Hyperlipidemia and the progression of renal disease. Am J Clin Nutr 1988; 47: 157-160.Keane W., Kasiske B., O'Donell M. Hyperlipidemia and the progression of renal disease. Am J Clin Nutr 1988; 47: 157-160.Keane W., Kasiske B., O'Donell M. Lipids and progressive glomerulosclerosis. Am J Nephrol 1988; 8: 261-281.Keane W., Kasiske B., O'Donell M. Lipids and progressive glomerulosclerosis. Am J Nephrol 1988; 8: 261-281.Kenner Ch., Evan A., Bromgren Ph. et al. Effect of protein intake on renal function and structure in partially nephrectomized rats. Kidney int 1985; 27: 739-750.Kenner Ch., Evan A., Bromgren Ph. et al. Effect of protein intake on renal function and structure in partially nephrectomized rats. Kidney int 1985; 27: 739-750.King A., Levey A. Dietary proteins and renal function. JASN 1993; 3: 1723-1737.King A., Levey A. Dietary proteins and renal function. JASN 1993; 3: 1723-1737.Klahr S., Tripathy K. Evaluation of renal function in malnutrition. Arch Int Med 1966; 118: 322-325.Klahr S., Tripathy K. Evaluation of renal function in malnutrition. Arch Int Med 1966; 118: 322-325.Klahr S., Levey A., Beck G. et al. The effects of dietary protein restriction and blood pressure control on the progression of chronic renal disease. N Engl J Med 1994; 330: 877-884.Klahr S., Levey A., Beck G. et al. The effects of dietary protein restriction and blood pressure control on the progression of chronic renal disease. N Engl J Med 1994; 330: 877-884.Kleinknecht C., Laounari D., Thorel D. et al. Protein diet and uremic toxicity: myth or reality? Kidney int 1987; 32; Suppl. 22: 62-66.Kleinknecht C., Laounari D., Thorel D. et al. Protein diet and uremic toxicity: myth or reality? Kidney int 1987; 32; Suppl. 22: 62-66.Kopple J., Coburn J. Metabolic studies of low protein diets in uremia: I. Nitrogen and potassium. Medicine 1973; 52: 583-595.Kopple J., Coburn J. Metabolic studies of low protein diets in uremia: I. Nitrogen and potassium. Medicine 1973; 52: 583-595.Kopple J., Swendseid M. Protein and aminoacid metabolism in uremic patients undergoing maintenance hemodialysis. Kidney int 1975; 7: S64-S72.Kopple J., Swendseid M. Protein and aminoacid metabolism in uremic patients undergoing maintenance hemodialysis. Kidney int 1975; 7: S64-S72.Kopple J., Monteon F., Shaib J. Effects of energy intake on nitrogen metabolism in nondialysed patients with chronic renal failure. Kidney int 1986; 22: 48-53.Kopple J., Monteon F., Shaib J. Effects of energy intake on nitrogen metabolism in nondialysed patients with chronic renal failure. Kidney int 1986; 22: 48-53.Кopple J., Levey A., Greene T. et al. Effect of dietary protein restriction on nutritional status in the Modification of Diet in Renal Disease study. Kidney int 1997; 52: 778-779.Кopple J., Levey A., Greene T. et al. Effect of dietary protein restriction on nutritional status in the Modification of Diet in Renal Disease study. Kidney int 1997; 52: 778-779.Kronenberg F., Utermann G., Dieplinger H. Lipoprotein(a) in renal desease. Am J Kidney Dis 1996; 27: 1-25.Kronenberg F., Utermann G., Dieplinger H. Lipoprotein(a) in renal desease. Am J Kidney Dis 1996; 27: 1-25.Lafage M.H., Combe Ch., Fournier A., Aparicio M. Ketodiet, physiological calcium intake and native vitamin D improve renal osteodystrophy. Kidney int 1992; 42: 1217-1225.Lafage M.H., Combe Ch., Fournier A., Aparicio M. Ketodiet, physiological calcium intake and native vitamin D improve renal osteodystrophy. Kidney int 1992; 42: 1217-1225.Laouari D., Kleinknecht C., Habib R. et al. The roles of phosphorus deficiency and low food intake in the preservation of renal function in uraemic rats. Experientia 1982; 38; 6: 681-682.Laouari D., Kleinknecht C., Habib R. et al. The roles of phosphorus deficiency and low food intake in the preservation of renal function in uraemic rats. Experientia 1982; 38; 6: 681-682.Laouari D., Kleinknecht C., Broyer M. Utilisation des keto-analogues d'acides amines dans l'insuffisance renale chronique. Nephrologie 1986; 7: 133-137.Laouari D., Kleinknecht C., Broyer M. Utilisation des keto-analogues d'acides amines dans l'insuffisance renale chronique. Nephrologie 1986; 7: 133-137.Laouari D., Rocchiccioli F., Dodu C. et al. Conversion of two branched-chain a-ketoanalogs in normal and uremic rats. Kidney int 1987; 32; Suppl. 22: S186-S190.Laouari D., Rocchiccioli F., Dodu C. et al. Conversion of two branched-chain a-ketoanalogs in normal and uremic rats. Kidney int 1987; 32; Suppl. 22: S186-S190.Lim V., Kopple J. Protein metabolism in patients with chronic renal failure. Role of uremia and dialysis. Kidney int 2000; 58: 1-10.Lim V., Kopple J. Protein metabolism in patients with chronic renal failure. Role of uremia and dialysis. Kidney int 2000; 58: 1-10.Lindenau K., Kokot F., Fröhling T. Supression of parathyroid hormone by therapy with a mixture of keto analogues/amino acidis in hemodialysis patient. Nephron 1986; 43: 84-86.Lindenau K., Kokot F., Fröhling T. Supression of parathyroid hormone by therapy with a mixture of keto analogues/amino acidis in hemodialysis patient. Nephron 1986; 43: 84-86.Lindenau K., Abendroth K., Kokot F. et al. Therapeutic effect of keto-acids on renal osteodystrophy. Nephron 1990; 55: 113-135.Lindenau K., Abendroth K., Kokot F. et al. Therapeutic effect of keto-acids on renal osteodystrophy. Nephron 1990; 55: 113-135.Locatelli F., Marselli D., Ponti R. et al. Effect of low protein diet on the progression of adult dominant polycystic kidney disease. Seminar on cystic renal disease. Milano: 1989: 47-52.Locatelli F., Marselli D., Ponti R. et al. Effect of low protein diet on the progression of adult dominant polycystic kidney disease. Seminar on cystic renal disease. Milano: 1989: 47-52.Locatelli F., Alberti D., Graziani G. et al. Prospective, randomised, multicentre trail of effect of protein restriction on progression of chronic renal insufficiency. Lancet 1991; 337: 1299-1304.Locatelli F., Alberti D., Graziani G. et al. Prospective, randomised, multicentre trail of effect of protein restriction on progression of chronic renal insufficiency. Lancet 1991; 337: 1299-1304.Loschiavo C., Ferrari S., Panebianco R. et al. Effect of protein-restricted diet on serum lipids and atherosclerosis risk factors in patients with chronic renal failure. Clin Nephrol 1988; 29: 113-118.Loschiavo C., Ferrari S., Panebianco R. et al. Effect of protein-restricted diet on serum lipids and atherosclerosis risk factors in patients with chronic renal failure. Clin Nephrol 1988; 29: 113-118.Lucas P.A., Brown R.C., Woodhead J.S. et al. 1,25-dihydroxycholecalciferol and parathyroid hormon in advanced chronic renal failure: effects of simultaneous protein and phosphorus restriction. Clin Nephrol 1986; 25: 7-10.Lucas P.A., Brown R.C., Woodhead J.S. et al. 1,25-dihydroxycholecalciferol and parathyroid hormon in advanced chronic renal failure: effects of simultaneous protein and phosphorus restriction. Clin Nephrol 1986; 25: 7-10.Lucas Ph., Meadows J., Roberts D. et al. The risk and benefits of a low protein-essential amino acid-keto acid diet. Kidney int 1986; 29: 995-1003.Lucas Ph., Meadows J., Roberts D. et al. The risk and benefits of a low protein-essential amino acid-keto acid diet. Kidney int 1986; 29: 995-1003.Lumlertgul D., Bruke T., Gillum D. et al. Phosphate depletion arrests progression of chronic renal failure independent of protein intake. Kidney int 1986; 29: 658-666.Lumlertgul D., Bruke T., Gillum D. et al. Phosphate depletion arrests progression of chronic renal failure independent of protein intake. Kidney int 1986; 29: 658-666.Maroni B. Protein restriction and malnutrition in renal disease: fact of fiction? Miner Electrolyte Metab 1997; 23: 225-228.Maroni B. Protein restriction and malnutrition in renal disease: fact of fiction? Miner Electrolyte Metab 1997; 23: 225-228.Maroni B., Staffeld C., Young V. et al. How is lean body mass concerved with the very low protein regimen? Miner Electrolyte Metab 1996; 22: 54-57.Maroni B., Staffeld C., Young V. et al. How is lean body mass concerved with the very low protein regimen? Miner Electrolyte Metab 1996; 22: 54-57.Maroni B. Impact of chronic renal failure on nitrogen metabolism. Miner Electrolyte Metab 1998; 24: 34-40.Maroni B. Impact of chronic renal failure on nitrogen metabolism. Miner Electrolyte Metab 1998; 24: 34-40.Maschio G., Oldriggi L., Tessitore N. et al. Effects of dietary protein and phosphorus restriction on the progression of early renal failure. Kidney int 1982; 22: 371-376.Maschio G., Oldriggi L., Tessitore N. et al. Effects of dietary protein and phosphorus restriction on the progression of early renal failure. Kidney int 1982; 22: 371-376.Masud T., Young V., Charman T. et al. Adaptive responses to very low protein diets: the first comparision of keto-acids to essential amino acids. Kidney int 1994; 45: 1182-1192.Masud T., Young V., Charman T. et al. Adaptive responses to very low protein diets: the first comparision of keto-acids to essential amino acids. Kidney int 1994; 45: 1182-1192.Mauer S., Steffer M., Asar S. et al. The effects of Golblatt hypertension on the development of the glomerular lesions of diabetes mellitus in the rat. Diabetes 1978; 27: 738-744.Mauer S., Steffer M., Asar S. et al. The effects of Golblatt hypertension on the development of the glomerular lesions of diabetes mellitus in the rat. Diabetes 1978; 27: 738-744.May R., Hara Y., Kelly R. et al. Branched chain amino acid metabolism in rat muscle: Abnormal regulation in acidosis. Am J Physiol 1987; 252: E712-E718.May R., Hara Y., Kelly R. et al. Branched chain amino acid metabolism in rat muscle: Abnormal regulation in acidosis. Am J Physiol 1987; 252: E712-E718.Meisinger E., Strauch M. Controlled trial of two keto-acid supplements on renal function, nutritional status and bone metabolism in uremic patients. Kidney int 1987; 32; Suppl. 22: S170-S173.Meisinger E., Strauch M. Controlled trial of two keto-acid supplements on renal function, nutritional status and bone metabolism in uremic patients. Kidney int 1987; 32; Suppl. 22: S170-S173.Mitch W., Walser M., Sapir D. Nitrogen sparing induced by leucine compared with that induced by its keto-analogue, alpha-ketoisocaproate in fasting obese man. J Clin Investing 1981; 67: 553-562.Mitch W., Walser M., Sapir D. Nitrogen sparing induced by leucine compared with that induced by its keto-analogue, alpha-ketoisocaproate in fasting obese man. J Clin Investing 1981; 67: 553-562.Mitch W., Steinman T., Walser M. The effect of protein restriction plus ketoacids on progression of chronic renal failure. Clin Res 1983; 31: 437.Mitch W., Steinman T., Walser M. The effect of protein restriction plus ketoacids on progression of chronic renal failure. Clin Res 1983; 31: 437.Mitch W., Clark A. Specifity of the effect of leucin and its metabolites on protein degradation in skeletal muscle. Biochem J 1984; 222: 579-586.Mitch W., Clark A. Specifity of the effect of leucin and its metabolites on protein degradation in skeletal muscle. Biochem J 1984; 222: 579-586.Mitch W. Dietary protein restriction and progressive renal insufficiency. Am J Kidney Dis 1997; 30 (2): 297-300.Mitch W. Dietary protein restriction and progressive renal insufficiency. Am J Kidney Dis 1997; 30 (2): 297-300.Monzani G., Bergegio F., Ciuti R. et al. Lp(a) levels: effects of progressive chronic renal failure and dietary management. J Nephrol 1997; 10: 41-45.Monzani G., Bergegio F., Ciuti R. et al. Lp(a) levels: effects of progressive chronic renal failure and dietary management. J Nephrol 1997; 10: 41-45.Nanra R., Kelson K. Chronic renal failure (CRF) diet without amino acid (AA) supplements in progressive renal disease: a controlled trial. Kidney int 1989; 35: 737.Nanra R., Kelson K. Chronic renal failure (CRF) diet without amino acid (AA) supplements in progressive renal disease: a controlled trial. Kidney int 1989; 35: 737.Nath K., Hostetter M., Hostetter T. Ammonia-complement interaction in the pathogenesis progressive renal injury. Kidney int 1989; 36; Suppl. 27: S52-S54.Nath K., Hostetter M., Hostetter T. Ammonia-complement interaction in the pathogenesis progressive renal injury. Kidney int 1989; 36; Suppl. 27: S52-S54.Nelson P., Shankland S. Therapeutics in renal disease: the road ahead for antiproliferaferative targets. Nephron 2006; 103: e6-e15.Nelson P., Shankland S. Therapeutics in renal disease: the road ahead for antiproliferaferative targets. Nephron 2006; 103: e6-e15.NKF=K/DOQI Clinical Practice Guideline for Nutrition in Chronic Renal Failure. Am J Kidney Dis 2000; 35; Suppl. 2: S. 60-61.NKF=K/DOQI Clinical Practice Guideline for Nutrition in Chronic Renal Failure. Am J Kidney Dis 2000; 35; Suppl. 2: S. 60-61.Obrador G., Arora P., Kausz A.T. et al. Pre-end stage disease care in the United States: a state of disrepair. J Am Soc Nephrol 1998; 9: S44-S54.Obrador G., Arora P., Kausz A.T. et al. Pre-end stage disease care in the United States: a state of disrepair. J Am Soc Nephrol 1998; 9: S44-S54.Oldrizzi L., Rugiu C., Valvo E. et al. Progression of renal failure in patients with renal diseases of diverse etiology on protein-restricted diet. Kidney int 1985; V27: 553-557.Oldrizzi L., Rugiu C., Valvo E. et al. Progression of renal failure in patients with renal diseases of diverse etiology on protein-restricted diet. Kidney int 1985; V27: 553-557.Paradoyaunakis N., Stefanides C., Patricarea A. et al. The effect of calcium carbonate administration on nitrogen metabolism in patients on hemodialysis. Proc EDTA 1985; 22: 83-87.Paradoyaunakis N., Stefanides C., Patricarea A. et al. The effect of calcium carbonate administration on nitrogen metabolism in patients on hemodialysis. Proc EDTA 1985; 22: 83-87.Pedrini M., Levey A., Lau J. et al. The effect dietary restriction on the progression of diabetic and non-diabetic renal diseases: a meta-analysis. Ann Intern Med 1996; 124: 627-632.Pedrini M., Levey A., Lau J. et al. The effect dietary restriction on the progression of diabetic and non-diabetic renal diseases: a meta-analysis. Ann Intern Med 1996; 124: 627-632.Peuchant E., Delmas-Beauvieux M., Dubourg L. et al. Antioxidant effects of supplemented very low protein diet in chronic renal failure. Free Radical Biol Med 1997; 22: 313-320.Peuchant E., Delmas-Beauvieux M., Dubourg L. et al. Antioxidant effects of supplemented very low protein diet in chronic renal failure. Free Radical Biol Med 1997; 22: 313-320.Prakash S., Pande D., Sharma S. et al. Randomized, double-blind, placebo-controlled trial to evaluate efficacy to ketodiet in predialytic chronic renal failure. J Renal Nutr 2004; 14: 86-96.Prakash S., Pande D., Sharma S. et al. Randomized, double-blind, placebo-controlled trial to evaluate efficacy to ketodiet in predialytic chronic renal failure. J Renal Nutr 2004; 14: 86-96.Rose W. Amino acid requirements in man. Fed Proc 1949; 8: 546-542.Rose W. Amino acid requirements in man. Fed Proc 1949; 8: 546-542.Rosman J., Meijer S., Sluiter W. et al. Prospective randomized trial of early dietary protein restriction in chronic renal failure. Lancet 1984; II: 1291-95.Rosman J., Meijer S., Sluiter W. et al. Prospective randomized trial of early dietary protein restriction in chronic renal failure. Lancet 1984; II: 1291-95.Rosman J., ter Wee P. Relationship between proteinuria and response to low protein diets early in chronic renal failure. Blood Purif 1989; 7: 52-57.Rosman J., ter Wee P. Relationship between proteinuria and response to low protein diets early in chronic renal failure. Blood Purif 1989; 7: 52-57.Schaefer K., Herrath D., Asmus G. et al. The beneficial effect of ketoacids on serum phosphate and parathyroid hormone in patient with chronic uremia. Clin Nephrol 1988; 30; 2: 93-96.Schaefer K., Herrath D., Asmus G. et al. The beneficial effect of ketoacids on serum phosphate and parathyroid hormone in patient with chronic uremia. Clin Nephrol 1988; 30; 2: 93-96.Schaefer K., Erley C., von Herrath D., Stein G. Calcium salts of keto-acid as a new treatment strategy for uremic hyperphosphatemia. Kidney int 1989; 36; Suppl. 27: S136-S139.Schaefer K., Erley C., von Herrath D., Stein G. Calcium salts of keto-acid as a new treatment strategy for uremic hyperphosphatemia. Kidney int 1989; 36; Suppl. 27: S136-S139.Seifart G., Ensminger A., Scholz R. Increase in body mass during long term bicarbonate dialysis. Kidney int 1987; 31; Suppl. 22: S174-177.Seifart G., Ensminger A., Scholz R. Increase in body mass during long term bicarbonate dialysis. Kidney int 1987; 31; Suppl. 22: S174-177.Seyer-Hansen J., Gundersen H. Renal hypertrophy in experimental diabetes: a morphometric study. Diabetologia 1980; 18: 501-505.Seyer-Hansen J., Gundersen H. Renal hypertrophy in experimental diabetes: a morphometric study. Diabetologia 1980; 18: 501-505.Smadel J., Farr L. The effect of diet on the pathological changes in rats with nephrotoxic nephritis. Am J Physiol 1939; 13: 199-221.Smadel J., Farr L. The effect of diet on the pathological changes in rats with nephrotoxic nephritis. Am J Physiol 1939; 13: 199-221.Steffes M., Brown D., Maucr S. Diabetic glomerulopathy following unilateral nephrectomy in the rat. Diabetes 1978; 27: 35-41.Steffes M., Brown D., Maucr S. Diabetic glomerulopathy following unilateral nephrectomy in the rat. Diabetes 1978; 27: 35-41.Teoduoru C., Saifer A., Frankel H. Conditioning factors influence evolution of experimental glomerulonephritis in rabbits. Am J Physiol 1954; 193: 457-460.Teoduoru C., Saifer A., Frankel H. Conditioning factors influence evolution of experimental glomerulonephritis in rabbits. Am J Physiol 1954; 193: 457-460.Teplan V., Schück O., Horanova M., Skibova J. Effect of ketoacid-amino supplement on the metabolism and renal elimination of branched chain amino acids in patients with chronic renal insufficiency on low protein diet. Wien klin. Wschr 2000; 112: 876-881.Teplan V., Schück O., Horanova M., Skibova J. Effect of ketoacid-amino supplement on the metabolism and renal elimination of branched chain amino acids in patients with chronic renal insufficiency on low protein diet. Wien klin. Wschr 2000; 112: 876-881.Teplan V., Schück O., Votrula M. et al. Metabolic effects of keto acid-amino acid supplementation in patients with chronic renal insufficiency receiving a low protein diet and recombinant human erythropoietin - randomized controlled trial. Wien klin. Wschr 2001; 113: 661-669.Teplan V., Schück O., Votrula M. et al. Metabolic effects of keto acid-amino acid supplementation in patients with chronic renal insufficiency receiving a low protein diet and recombinant human erythropoietin - randomized controlled trial. Wien klin. Wschr 2001; 113: 661-669.Tom K., Young V., Charman T. et al. Long-term adaptive responses to low protein diet in chronic renal failure. Am J Physiol 1995; 268: F668-F677.Tom K., Young V., Charman T. et al. Long-term adaptive responses to low protein diet in chronic renal failure. Am J Physiol 1995; 268: F668-F677.Traynor J., Simpson K., Geddes C. et al. Early initiation of dialysis fails to prolong survival in patients with end-stage renal failure. J Am Soc Nephrol 2002; 13: 2125-2132.Traynor J., Simpson K., Geddes C. et al. Early initiation of dialysis fails to prolong survival in patients with end-stage renal failure. J Am Soc Nephrol 2002; 13: 2125-2132.Trevino-Bessera A., Lopez J., Alanis L. Ketoanalogues and a very low-protein diet diminism serum cholesterol in predialysis patients. Dialysis and transplantation 2002; 31: 25-26.Trevino-Bessera A., Lopez J., Alanis L. Ketoanalogues and a very low-protein diet diminism serum cholesterol in predialysis patients. Dialysis and transplantation 2002; 31: 25-26.Tungsanga K., Kang Ch., Walser M. Utilisation of alpha-ketoisocaproate for protein synthesis in uremic rats. Kidney int 1986; 30: 891-894.Tungsanga K., Kang Ch., Walser M. Utilisation of alpha-ketoisocaproate for protein synthesis in uremic rats. Kidney int 1986; 30: 891-894.United States Renal Date System: The USRDS: Morbidity and Mortality Study Wave 2. Am J Kidney Dis 1997; 30; Suppl. 1: S67-S68.United States Renal Date System: The USRDS: Morbidity and Mortality Study Wave 2. Am J Kidney Dis 1997; 30; Suppl. 1: S67-S68.Venderly B., Chauveau P., Barthe N. et al. Nutrition in hemodialysis patients previously on a supplemented very low protein diet. Kidney int 2003; 63: 1491-1498.Venderly B., Chauveau P., Barthe N. et al. Nutrition in hemodialysis patients previously on a supplemented very low protein diet. Kidney int 2003; 63: 1491-1498.Verberckmoes R., Van Rerterghem Y. Can the effects of protein restriction on the progression of renal failure also be achieved by pharmacological means? Blood Purif 1989; 7: 58-60.Verberckmoes R., Van Rerterghem Y. Can the effects of protein restriction on the progression of renal failure also be achieved by pharmacological means? Blood Purif 1989; 7: 58-60.Volhard F. Die doppelseitigen hämatogenen Nierenerkrankungen (Bright'sche Krankheit). Handbuсh der inneren Medezin, Berlin, Springer 1918: S. 1149-1172.Volhard F. Die doppelseitigen hämatogenen Nierenerkrankungen (Bright'sche Krankheit). Handbuсh der inneren Medezin, Berlin, Springer 1918: S. 1149-1172.Walker W., Gimenez L., Tew W. et al. Prevention of phosphate induced progression of experimental uremia by 3-phosphocitric acid. Proc. 5-th Int. Workshop «Phosphate and other Miner». London: 1982: 157-166.Walker W., Gimenez L., Tew W. et al. Prevention of phosphate induced progression of experimental uremia by 3-phosphocitric acid. Proc. 5-th Int. Workshop «Phosphate and other Miner». London: 1982: 157-166.Walser M., La France D., Ward L., Van Duym M. Progression of chronic renal failure in patients given ketoacids following amino acid. Kidney int 1987; 32: 123-128.Walser M., La France D., Ward L., Van Duym M. Progression of chronic renal failure in patients given ketoacids following amino acid. Kidney int 1987; 32: 123-128.Walser M. Dietary proteins and their relationship to kidney disease. In book: Dietary proteins in health and disease 1992: 168-178.Walser M. Dietary proteins and their relationship to kidney disease. In book: Dietary proteins in health and disease 1992: 168-178.Walser M. Does prolonged protein restriction preceding dialysis lead to protein malnutrition at the onset of dialysis? Kidney int 1993; 44: 1139-1144.Walser M. Does prolonged protein restriction preceding dialysis lead to protein malnutrition at the onset of dialysis? Kidney int 1993; 44: 1139-1144.Walser M., Hill S. Can renal replacement be deferred by a supplemented very low protein diet. J Am Soc Nephrol 1999; 10: 110-116.Walser M., Hill S. Can renal replacement be deferred by a supplemented very low protein diet. J Am Soc Nephrol 1999; 10: 110-116.Walser M., Mitch W., Maroni B. et al. Should protein intake be restricted in predialysis patients? Kidney Int 1999; 55: 771-777.Walser M., Mitch W., Maroni B. et al. Should protein intake be restricted in predialysis patients? Kidney Int 1999; 55: 771-777.Walser M. Is there a role for protein restriction in the treatment of chronic renal failure? Blood Purif 2000; 18: 304-312.Walser M. Is there a role for protein restriction in the treatment of chronic renal failure? Blood Purif 2000; 18: 304-312.Walter F., Addis T. Organ work and organ weight. J Exp Med 1939; 69: 467-483.Walter F., Addis T. Organ work and organ weight. J Exp Med 1939; 69: 467-483.Williams B., Hattersley J., Layward E., Walls J. Metabolic acidosis and skeletal muscle adaptation to low protein diets in chronical uremia. Kidney int 1991; 40: 779-786.Williams B., Hattersley J., Layward E., Walls J. Metabolic acidosis and skeletal muscle adaptation to low protein diets in chronical uremia. Kidney int 1991; 40: 779-786.Wiserman M., Bogneetti E., Dodds R. et al. Changes in renal failure in response to protein restriction diet in type 1 (insulin dependent) diabetic patients. Diabetologia 1987; 30: 154-159.Wiserman M., Bogneetti E., Dodds R. et al. Changes in renal failure in response to protein restriction diet in type 1 (insulin dependent) diabetic patients. Diabetologia 1987; 30: 154-159.Yong G., Keogh J., Parsons F. Plasma amino acids and protein levels in chronic renal failure and changes caused by oral supplemention of essential amino acid. Clin Chim Acta 1975; 61: 205-213.Yong G., Keogh J., Parsons F. Plasma amino acids and protein levels in chronic renal failure and changes caused by oral supplemention of essential amino acid. Clin Chim Acta 1975; 61: 205-213.Yoshida Y., Fogo A., Ichicava I. Glomerular hypertrophy has a great impact on glomerular sclerosis than adaptive hyperperfusion in remnant nephrons. Kidney int 1988; 33: 327.Yoshida Y., Fogo A., Ichicava I. Glomerular hypertrophy has a great impact on glomerular sclerosis than adaptive hyperperfusion in remnant nephrons. Kidney int 1988; 33: 327.Zakar G. The effect of keto acid supplement on the course of chronic renal failure and nutritional parameters in predialysis patients and patients on regular dialysis theraphy: the Hungarian ketosteril cohort study. Wien klin Wschrт 2001; 113: S688-694.Zakar G. The effect of keto acid supplement on the course of chronic renal failure and nutritional parameters in predialysis patients and patients on regular dialysis theraphy: the Hungarian ketosteril cohort study. Wien klin Wschrт 2001; 113: S688-694.Zatz R., Meyer T., Rennke H., Brenner B. Predominance of hemodynamic rather than methabolic factors in the pathogenesis of diabetic glomerulopathy. Proc Natl Acad Sci USA 1985; 82: 5963-5967.Zatz R., Meyer T., Rennke H., Brenner B. Predominance of hemodynamic rather than methabolic factors in the pathogenesis of diabetic glomerulopathy. Proc Natl Acad Sci USA 1985; 82: 5963-5967.

The authors declare that there are no conflicts of interest present.