nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-1570Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESМикофенолата мофетил в терапии гломерулопатий у детейMycophenolate mofetil in treatment of children with glomerulopathiesКанатбаеваА. Б.KanatbayevaA. B.noemail@neicon.ruДиканбаеваС. А.DikanbayevaS. A.noemail@neicon.ruАбеуоваБ. А.AbeuovaB. A.noemail@neicon.ruКарабидиП. П.KarabidiP. P.noemail@neicon.ruНаушабаеваА. Е.NaushabayevaA. E.noemail@neicon.ruНигматуллинаН. Б.NigmatullinaN. B.noemail@neicon.ruМустапаеваН. М.MustapaevaN. M.noemail@neicon.ruКазахский национальный медицинский университетRussian FederationРеспубликанская детская клиническая больница «Аксай»; г. Алматы, КазахстанRussian Federation20062306202584355358Copyright © Канатбаева А.Б., Диканбаева С.А., Абеуова Б.А., Карабиди П.П., Наушабаева А.Е., Нигматуллина Н.Б., Мустапаева Н.М., 20252025Канатбаева А.Б., Диканбаева С.А., Абеуова Б.А., Карабиди П.П., Наушабаева А.Е., Нигматуллина Н.Б., Мустапаева Н.М.Kanatbayeva A.B., Dikanbayeva S.A., Abeuova B.A., Karabidi P.P., Naushabayeva A.E., Nigmatullina N.B., Mustapaeva N.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/1570

Проведена оценка терапии микофенолата мофетилом у 20 детей (8 - с гормон-зависимым и гормон-резистентным нефротическим синдромом, 5 - с хроническим гломерулонефритом нефритического типа, 6 - с нефритом Шенлейн-Геноха и 1 - с люпус-нефритом). Лечение оказалось наиболее эффективным у больных с гормон-зависимым нефротическим синдромом, также достигнута частичная ремиссия у большей части больных с хроническим нефритическим синдромом и с нефритом Шенлейн-Геноха.

In this study an efficacy of Mycophenolate Mofetil in 20 children (8 with steroid-dependent and steroid-resistant nephrotic syndrome, 5 with chronic glomerulonephritis of nephritic type, 6 with Genoch-Shoenlein nephritis and 1 with lupus-nephritis) was assessed. Treatment with Mycophenolate Mofetil was more efficient in children with steroid-dependent nephrotic syndrome. It was also effective in children with chronic nephritic syndrome and Genoch-Shoenlein nephritis.

микофенолата мофетилнефротический синдромхронический нефритический синдромлюпус-нефритдетиReferencesAllison A.C., Eugui E.M., Sollinger H.W. Mycophenolate mofetil (RS-61443): Mechanism of action and effects in transplantation. Transplant Rev 1993; 61: 129-139.Allison A.C., Eugui E.M., Sollinger H.W. Mycophenolate mofetil (RS-61443): Mechanism of action and effects in transplantation. Transplant Rev 1993; 61: 129-139.Allison A.C., Eugui E.M. Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil. Immunol Rev 1993; 136: 1.Allison A.C., Eugui E.M. Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil. Immunol Rev 1993; 136: 1.Bagga A., Hari P., Moudgil A., Jordan S.C. Mycophenolate mofetil and prednisolone therapy in children with steroid dependent nephrotic syndrome. Am J Kidney Dis 2003; 42 (6): 1114-1120.Bagga A., Hari P., Moudgil A., Jordan S.C. Mycophenolate mofetil and prednisolone therapy in children with steroid dependent nephrotic syndrome. Am J Kidney Dis 2003; 42 (6): 1114-1120.Briggs W.A., Choi M.J., Sheel P.J. Successful mycophenolate mofetil treatment of glomerular disease. Am J Kidney Dis 1998; 31: 213-217.Briggs W.A., Choi M.J., Sheel P.J. Successful mycophenolate mofetil treatment of glomerular disease. Am J Kidney Dis 1998; 31: 213-217.Day C.J., Cockwell P., Lipkin G.W. et al. Mycophenolate mofetil in the treatment of resistant idiopatic nephrotic syndrome. Nephrol Dial Transplant 2002; 17 (11): 2011-2013.Day C.J., Cockwell P., Lipkin G.W. et al. Mycophenolate mofetil in the treatment of resistant idiopatic nephrotic syndrome. Nephrol Dial Transplant 2002; 17 (11): 2011-2013.Hauser I.A., Renders L., Radeke H. et al. Mycophenolate mofetil inhibits rat and human mesangial cell proliferation by guanosin depletion. Nephrol Dial Transpl 1999; 14: 58-62.Hauser I.A., Renders L., Radeke H. et al. Mycophenolate mofetil inhibits rat and human mesangial cell proliferation by guanosin depletion. Nephrol Dial Transpl 1999; 14: 58-62.Hogg R.J., Fizgibbons L., Bruick J. et al. Multicenter trial of mycophenolate mofetil (MMF) in children with steroid dependent (SD) or frequent relapsing (FR) nephrotic syndrome (NS). Report of the southwest pediatric nephrology study group. Nephrol Dial Transplant 2003; 18; Suppl. 4: 261.Hogg R.J., Fizgibbons L., Bruick J. et al. Multicenter trial of mycophenolate mofetil (MMF) in children with steroid dependent (SD) or frequent relapsing (FR) nephrotic syndrome (NS). Report of the southwest pediatric nephrology study group. Nephrol Dial Transplant 2003; 18; Suppl. 4: 261.Miller G., Zimmerman R. 3rd., Radhakrishan J., Appel G. Use of mycophenolate mofetil in resistant membranous nephropathy. Am J Kidney Dis 2000, Aug; 36 (2): 250-256.Miller G., Zimmerman R. 3rd., Radhakrishan J., Appel G. Use of mycophenolate mofetil in resistant membranous nephropathy. Am J Kidney Dis 2000, Aug; 36 (2): 250-256.Mogyorosi A., Lippman H.R., Feldman G.M. Successful treatment of steroid resistant minimal change disease with mycophenolate mofetil Am J Ntphrol 2002; 22 (5-6): 569-572.Mogyorosi A., Lippman H.R., Feldman G.M. Successful treatment of steroid resistant minimal change disease with mycophenolate mofetil Am J Ntphrol 2002; 22 (5-6): 569-572.Norona B., Valentun M., Gutierrez T., Praga M. Treatment of steroid dependent minimal change - nephrotic syndrome mycophenolate mofetil. Nefrologia 2004; 24 (1): 79-82.Norona B., Valentun M., Gutierrez T., Praga M. Treatment of steroid dependent minimal change - nephrotic syndrome mycophenolate mofetil. Nefrologia 2004; 24 (1): 79-82.Zhao M., Morris V., Holdman G.N. et al. Mycophenolate mofetil in the treatment of resistant nephrotic syndrome. Am J Kidney Dis 2001; 46 (5): 35-39.Zhao M., Morris V., Holdman G.N. et al. Mycophenolate mofetil in the treatment of resistant nephrotic syndrome. Am J Kidney Dis 2001; 46 (5): 35-39.

The authors declare that there are no conflicts of interest present.