References

nid

Нефрология и диализ

Nephrology and Dialysis

1680-44222618-9801

Российское диализное общество

nid-1605

Research Article

ОБЗОРЫ И ЛЕКЦИИ

REVIEWS AND LECTURES

Патогенетические основы нефросклероза (Обзор литературы)

Pathogenesis of renal scarring Review

Паунова

С. С.

Paunova

S. S.

ss_paunova@public.mtu.ru

Российский государственный медицинский университет, г. МоскваRussian Federation

2005

25062025

72130135

2025

Паунова С.С.

Paunova S.S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.nephro.ru/jour/article/view/1605

Прогрессирование всех почечных болезней характеризует одна общая черта - клеточная пролиферация с последующим накоплением внеклеточного матрикса и сморщиванием ткани. При этом гломерулосклероз и фиброз интерстиция являются ключевыми элементами в развитии терминальной стадии почечной недостаточности. Исследования последних лет указывают на возможность влияния ряда факторов (гуморальных и клеточных) на процесс фиброгенеза. Согласно законам общей патологии в ответ на повреждение (механическое или инфекционное) клетки вырабатывают комплекс вазоактивных, про- и противовоспалительных, просклеротических и проапоптозных медиаторов. Результаты многочисленных исследований, приведенные в обзоре, свидетельствуют о существовании механизмов интеграции комплекса медиаторов воспаления, дисбаланс которых обуславливает развитие фиброза в поврежденных тканях, что особенно важно при болезнях почек у детей.

Proliferation of interstitial fibroblasts and excessive deposition of interstitial extracellular matrix leading to fibrosis is typical for progression of all renal diseases. Recent investigations show the crucial role of vasoactive, pro- and antyinflammatory, proapoptotic mediators and growth factors in renal scar formation. The review describes the main pathways of nephrosclerosis development in view of integral interaction of different mediators.

цитокиныфакторы ростаоксид азотапростагландинывоспалениефиброгенезапоптоз

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The authors declare that there are no conflicts of interest present.