nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-1964Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESМеханизмы нефросклефоза; фармакологическая ингибиция внутрипочечной ренин-ангиотензиновой системы как основа нефропротективной стратегии при хронических заболеваниях нативных почек и почечного трансплантата (Обзор литературы)Mechanisms of nephrosclerosis; pharmacological inhibition of renal RAS as a basis of nephroprotective streategy in chronic kidney disease of native and allograft (refferences revue)ТомилинаН. А.TomilinaN. A.natomil@online.ruБагдасарянА. Р.BagdasaryanA. R.noemail@neicon.ruНИИ трансплантологии и искусственных органов МЗ РФ, кафедра нефрологии Московского государственного медико-стоматологического университета МЗ РФ, МоскваRussian Federation20042706202563226234Copyright © Томилина Н.А., Багдасарян А.Р., 20252025Томилина Н.А., Багдасарян А.Р.Tomilina N.A., Bagdasaryan A.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/1964

Вопрос о механизмах прогрессирования хронических заболеваний почек является одним из центральных в современной нефрологии. На протяжении последних двух с половиной десятилетий его изучение ознаменовалось рядом открытий, которые позволили сформулировать современную концепцию патогенеза нефросклероза. Стало очевидным, в частности, что прогрессирование любых хронических заболеваний почек, независимо от их природы, определяется действием совокупности одних и тех же клеточных и молекулярных механизмов, которые с биологической точки зрения представляют собой комплекс процессов, направленных на репарацию тканей организма в ответ на их повреждение [101, 102].

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The authors declare that there are no conflicts of interest present.