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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nid</journal-id><journal-title-group><journal-title xml:lang="ru">Нефрология и диализ</journal-title><trans-title-group xml:lang="en"><trans-title>Nephrology and Dialysis</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1680-4422</issn><issn pub-type="epub">2618-9801</issn><publisher><publisher-name>Российское диализное общество</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">nid-1973</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Вторичный гиперпаратиреоз при хронической почечной недостаточности. Лечение активными метаболитами витамина D</article-title><trans-title-group xml:lang="en"><trans-title>Secondary hyperparathyroidism in patients with chronic renal failure. The treatment with active metabolites of vitamin D</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Волгина</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Volgina</surname><given-names>G. V.</given-names></name></name-alternatives><email xlink:type="simple">volginagv@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Московский государственный медико-стоматологический университет МЗ РФ, Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2004</year></pub-date><pub-date pub-type="epub"><day>27</day><month>06</month><year>2025</year></pub-date><volume>6</volume><issue>2</issue><fpage>116</fpage><lpage>126</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Волгина Г.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Волгина Г.В.</copyright-holder><copyright-holder xml:lang="en">Volgina G.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nephro.ru/jour/article/view/1973">https://journal.nephro.ru/jour/article/view/1973</self-uri><abstract><p>За последнее десятилетие существенно изменилось понимание патофизиологических процессов, ведущих к развитию вторичного гиперпаратиреоза (ВГПТ) у больных с хронической почечной недостаточностью (ХПН). Вторичный гиперпаратиреоз является частым и грозным осложнением ХПН и развивается в результате относительного или абсолютного дефицита кальцитриола (КТ) и нарушения гомеостаза кальция и фосфора</p></abstract><kwd-group xml:lang="ru"><kwd>хроническая почечная недостаточность</kwd><kwd>фосфорно-кальциевый гомеостаз</kwd><kwd>гиперпаратиреоз</kwd><kwd>витамин D</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ермоленко В.М. Нарушение фосфорно-кальциевого обмена. Нефрология. Руководство для врачей. 2000: 62-75.</mixed-citation><mixed-citation xml:lang="en">Ермоленко В.М. Нарушение фосфорно-кальциевого обмена. Нефрология. Руководство для врачей. 2000: 62-75.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Розен В.Б. Основы эндокринологии. М.: МГУ, 1994: 384.</mixed-citation><mixed-citation xml:lang="en">Розен В.Б. Основы эндокринологии. М.: МГУ, 1994: 384.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Akizawa T., Fukagawa H., Koshikawa S., Kurosawa K. Recent progress in management secondary hyperparathyroidism of chronic renal failure. Curr Opin Hypertens 1993; 2: 558-565.</mixed-citation><mixed-citation xml:lang="en">Akizawa T., Fukagawa H., Koshikawa S., Kurosawa K. Recent progress in management secondary hyperparathyroidism of chronic renal failure. Curr Opin Hypertens 1993; 2: 558-565.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Alexiewicz J.M., Klinger M., Pitt S.M. et al. PTH inhibits B cell proliferation: implication in chronic renal failure. J Am Soc Nephrol 1990; 1: 236-244.</mixed-citation><mixed-citation xml:lang="en">Alexiewicz J.M., Klinger M., Pitt S.M. et al. PTH inhibits B cell proliferation: implication in chronic renal failure. J Am Soc Nephrol 1990; 1: 236-244.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Amann K., Ritz E., Wiest G., Klaus G., Mall G. A role of parathyroid hormone for activation of cardiac fibroblast in uremia. J Amer Soc Nephrol 1994; 4 (10): 1814-1819.</mixed-citation><mixed-citation xml:lang="en">Amann K., Ritz E., Wiest G., Klaus G., Mall G. A role of parathyroid hormone for activation of cardiac fibroblast in uremia. J Amer Soc Nephrol 1994; 4 (10): 1814-1819.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Arnold A., Brown M.F., Urena P., Gaz R.D., Sarfati E., Drueke T.B. Monoclonality of parathyroid tumors in chronic renal failure and in primary parathyroid hyperplasia. J Clin Invest 1995; 95: 2047-2053.</mixed-citation><mixed-citation xml:lang="en">Arnold A., Brown M.F., Urena P., Gaz R.D., Sarfati E., Drueke T.B. Monoclonality of parathyroid tumors in chronic renal failure and in primary parathyroid hyperplasia. J Clin Invest 1995; 95: 2047-2053.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bacchini G., Fabrizi F., Pontoriero G., Marcelli D., Filippo S.D., Locatelli F. «Pulse oral» versus intravenous calcitriol therapy in chronic hemodialysis patients: a prospective and randomized study. Nephron 1997; 77: 267-272. [Erratum, Nephron 1998; 79: 509].</mixed-citation><mixed-citation xml:lang="en">Bacchini G., Fabrizi F., Pontoriero G., Marcelli D., Filippo S.D., Locatelli F. «Pulse oral» versus intravenous calcitriol therapy in chronic hemodialysis patients: a prospective and randomized study. Nephron 1997; 77: 267-272. [Erratum, Nephron 1998; 79: 509].</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Block G.A., Hulberi-Shearon T.E., Levin N.W., Port F.K. Association of serum phosphorus and calcium[-phosphate product with mortality risk in chronic hemodialysis patients: a national study. Am J Kidney Dis 1998; 4: 607-617.</mixed-citation><mixed-citation xml:lang="en">Block G.A., Hulberi-Shearon T.E., Levin N.W., Port F.K. Association of serum phosphorus and calcium[-phosphate product with mortality risk in chronic hemodialysis patients: a national study. Am J Kidney Dis 1998; 4: 607-617.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Block G.A., Port F.K. Re-evaluation of risks associated with hyperphosphatemia and hyperparathyroidism in dialysis patients: recommendations for a change in management. Am J Kidney Dis 2000; 35: 1226-1237.</mixed-citation><mixed-citation xml:lang="en">Block G.A., Port F.K. Re-evaluation of risks associated with hyperphosphatemia and hyperparathyroidism in dialysis patients: recommendations for a change in management. Am J Kidney Dis 2000; 35: 1226-1237.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Brown A.J., Ritter C., Fineh J., Slatopolsky E. Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: role of dietary phosphate. Kidney Int 1999; 55: 1284-1292.</mixed-citation><mixed-citation xml:lang="en">Brown A.J., Ritter C., Fineh J., Slatopolsky E. Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: role of dietary phosphate. Kidney Int 1999; 55: 1284-1292.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Brown E.M., Pollak M., Riccardi D., Hebert S.C. Cloning and characterization of an extracellular Ca-sensing receptor from parathyroid and kidney: new insights into the physiology and pathophysiology of calcium metabolism. Nephrol Dial Transplant 1994; 9: 1703-1706.</mixed-citation><mixed-citation xml:lang="en">Brown E.M., Pollak M., Riccardi D., Hebert S.C. Cloning and characterization of an extracellular Ca-sensing receptor from parathyroid and kidney: new insights into the physiology and pathophysiology of calcium metabolism. Nephrol Dial Transplant 1994; 9: 1703-1706.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Brown E.M., Pollak M., Seidma M.C. et al. Calcium-Ion-Sensing Cell-Surface Receptors. N Engl J Med 1995; 333: 234-240.</mixed-citation><mixed-citation xml:lang="en">Brown E.M., Pollak M., Seidma M.C. et al. Calcium-Ion-Sensing Cell-Surface Receptors. N Engl J Med 1995; 333: 234-240.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Brown E.M., Gamba G., Riccardi D. et al. Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid. Nature 1993; 366: 575-580.</mixed-citation><mixed-citation xml:lang="en">Brown E.M., Gamba G., Riccardi D. et al. Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid. Nature 1993; 366: 575-580.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Brown E.M., Vassilev P.M., Quinn S., Hebert S.C. G-protein-coupled, extracellular Ca2+-sensing receptor: a versatile regulator of diverse cellular functions. Vitam Horm 1999; 55: 1-71.</mixed-citation><mixed-citation xml:lang="en">Brown E.M., Vassilev P.M., Quinn S., Hebert S.C. G-protein-coupled, extracellular Ca2+-sensing receptor: a versatile regulator of diverse cellular functions. Vitam Horm 1999; 55: 1-71.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cannata Andia J.B. Adynamic bone and chronic renal failure: an overview. Am J Med Sci 2000; 320: 81-84.</mixed-citation><mixed-citation xml:lang="en">Cannata Andia J.B. Adynamic bone and chronic renal failure: an overview. Am J Med Sci 2000; 320: 81-84.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Cholst I.N., Steinberg S.F., Tropper P.J. et al. The influence of hypermagnesemia on serum calcium and parathyroid hormone in human subjects. N Engl J Med 1984; 310: 1221-1225.</mixed-citation><mixed-citation xml:lang="en">Cholst I.N., Steinberg S.F., Tropper P.J. et al. The influence of hypermagnesemia on serum calcium and parathyroid hormone in human subjects. N Engl J Med 1984; 310: 1221-1225.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Chorev M., Alexander J.M., Rosenblatt M. Interactions of parathyroid hormone and parathyroid homone-related protein with their receptors. In: Bilezikian J.P., Levine M.A., Marcus R. eds. The parathyroids: basic and clinical concepts. 2nd ed. San Diego, Calif.: Academic Press (in press).</mixed-citation><mixed-citation xml:lang="en">Chorev M., Alexander J.M., Rosenblatt M. Interactions of parathyroid hormone and parathyroid homone-related protein with their receptors. In: Bilezikian J.P., Levine M.A., Marcus R. eds. The parathyroids: basic and clinical concepts. 2nd ed. San Diego, Calif.: Academic Press (in press).</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Chung U., Igarashi T., Nishishita T. et al. The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium. J Biol Chem 1996; 271: 8593-8598.</mixed-citation><mixed-citation xml:lang="en">Chung U., Igarashi T., Nishishita T. et al. The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium. J Biol Chem 1996; 271: 8593-8598.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Combe C., Aparicio M. Phosphorus and protein restriction and parathyroid function in chronic renal failure. Kidney Int 1994; 46: 1381-1386.</mixed-citation><mixed-citation xml:lang="en">Combe C., Aparicio M. Phosphorus and protein restriction and parathyroid function in chronic renal failure. Kidney Int 1994; 46: 1381-1386.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Demay M.B., Kiernan M.S., DeLuca H.F., Kronenberg H.M. Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A 1992; 89: 8097-8101.</mixed-citation><mixed-citation xml:lang="en">Demay M.B., Kiernan M.S., DeLuca H.F., Kronenberg H.M. Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A 1992; 89: 8097-8101.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Edwards R.M. Disorders of posphat metabolism in chronic renal disease. Curr Opin Pharmacol 2002; 2: 171-176.</mixed-citation><mixed-citation xml:lang="en">Edwards R.M. Disorders of posphat metabolism in chronic renal disease. Curr Opin Pharmacol 2002; 2: 171-176.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ellis R.E., Juan J., Horwitz H.R. Mechanism and function of cell death. Ann Rev Cell Biol 1991; 7: 663-698.</mixed-citation><mixed-citation xml:lang="en">Ellis R.E., Juan J., Horwitz H.R. Mechanism and function of cell death. Ann Rev Cell Biol 1991; 7: 663-698.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Falchetti A., Pale A.F., Amorosi A. Progression of uremic hyperparathyroidism involves alleic loss on chromosome 11. J Endocrinol Metab 1993; 76: 139-144.</mixed-citation><mixed-citation xml:lang="en">Falchetti A., Pale A.F., Amorosi A. Progression of uremic hyperparathyroidism involves alleic loss on chromosome 11. J Endocrinol Metab 1993; 76: 139-144.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Feinfeld D.A., Sherwood L.M. Parathyroid hormone and 1,25(OH)2D3 in chronic renal failure. Kidney Int 1988; 33: 1048-1058.</mixed-citation><mixed-citation xml:lang="en">Feinfeld D.A., Sherwood L.M. Parathyroid hormone and 1,25(OH)2D3 in chronic renal failure. Kidney Int 1988; 33: 1048-1058.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Fukagawa M. Cell biology of parathyroid hyperplasia in uremia. Am J Med Sci 1999; 317: 377-382.</mixed-citation><mixed-citation xml:lang="en">Fukagawa M. Cell biology of parathyroid hyperplasia in uremia. Am J Med Sci 1999; 317: 377-382.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Fukagawa M. Resistance of parathyroid cell to calcitriol as a cause of parathyroid hyperfunction in chronic renal failure. Nephrol Dial Transplant 1995; 2: 316-319.</mixed-citation><mixed-citation xml:lang="en">Fukagawa M. Resistance of parathyroid cell to calcitriol as a cause of parathyroid hyperfunction in chronic renal failure. Nephrol Dial Transplant 1995; 2: 316-319.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Fukagawa M., Ji M., Kurokawa K. Calcitriol-induce apoptosis of hyperplastic parathyroid cells in uremic rats. J Am Soc Nephrol 1991; 2: 635 (abstract).</mixed-citation><mixed-citation xml:lang="en">Fukagawa M., Ji M., Kurokawa K. Calcitriol-induce apoptosis of hyperplastic parathyroid cells in uremic rats. J Am Soc Nephrol 1991; 2: 635 (abstract).</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Fukuda N., Tanaka H., Tominaga Y., Fukagawa M., Kurokawa K., Seino Y. Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients. J Clin Invest 1993; 92: 1436-1443.</mixed-citation><mixed-citation xml:lang="en">Fukuda N., Tanaka H., Tominaga Y., Fukagawa M., Kurokawa K., Seino Y. Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients. J Clin Invest 1993; 92: 1436-1443.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Ganesh S.K., Stack A.G., Levin N.W., Hulbert-Shearon T., Port F.K. Association of elevated serum PO4, Ca x PO4 product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients. J Am Soc Nephrol 2001; 12: 2131-2138.</mixed-citation><mixed-citation xml:lang="en">Ganesh S.K., Stack A.G., Levin N.W., Hulbert-Shearon T., Port F.K. Association of elevated serum PO4, Ca x PO4 product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients. J Am Soc Nephrol 2001; 12: 2131-2138.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Gogusev H., Duchambon P., Hory B. еt al. Depressed expression of calcium receptor in parathyroid gland tissue of patient with hyperparathyroidism. Kidney Int 1997; 51: 328-336.</mixed-citation><mixed-citation xml:lang="en">Gogusev H., Duchambon P., Hory B. еt al. Depressed expression of calcium receptor in parathyroid gland tissue of patient with hyperparathyroidism. Kidney Int 1997; 51: 328-336.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Goodman W.G., Goldin J., Kuizon B.D. et al. Coronary artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 2000; 342: 1478-1483.</mixed-citation><mixed-citation xml:lang="en">Goodman W.G., Goldin J., Kuizon B.D. et al. Coronary artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 2000; 342: 1478-1483.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Goodman W.G. Recent developments in the management of secondary hyperparathyroidism. Kidney Int 2001; 59: 1187-1201.</mixed-citation><mixed-citation xml:lang="en">Goodman W.G. Recent developments in the management of secondary hyperparathyroidism. Kidney Int 2001; 59: 1187-1201.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Hasnain M., Hauncher C., Pegoraro A.A., Arruda J.A.L., Dunea G. Suppression of hyperparathyroidism by calcitriol therapy. ASAIO J 1999; 45: 424-427.</mixed-citation><mixed-citation xml:lang="en">Hasnain M., Hauncher C., Pegoraro A.A., Arruda J.A.L., Dunea G. Suppression of hyperparathyroidism by calcitriol therapy. ASAIO J 1999; 45: 424-427.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Hayakawa Y., Tanaka Y., Funahashi H. et al. Hyperphosphatemia accelerates parathyroid cell proliferation and parathyroid hormone secretion in severe secondary parathyroid hyperplasia. Endocr J 1999; 46: 681-686.</mixed-citation><mixed-citation xml:lang="en">Hayakawa Y., Tanaka Y., Funahashi H. et al. Hyperphosphatemia accelerates parathyroid cell proliferation and parathyroid hormone secretion in severe secondary parathyroid hyperplasia. Endocr J 1999; 46: 681-686.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Hercz G., Pei G., Greenwood C. еt al. Aplastic osteodistrophy without aluminium. The role of «supressed» parathyroid function. Kidney Int 1993; 44: 860-866.</mixed-citation><mixed-citation xml:lang="en">Hercz G., Pei G., Greenwood C. еt al. Aplastic osteodistrophy without aluminium. The role of «supressed» parathyroid function. Kidney Int 1993; 44: 860-866.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Herrmann P., Ritz E., Schmidt-Gayk H. et al. Comparison of intermittent and continuous oral administration of calcitriol in dialysis patients; a randomized prospective trial. Nephron 1994; 67: 48-53.</mixed-citation><mixed-citation xml:lang="en">Herrmann P., Ritz E., Schmidt-Gayk H. et al. Comparison of intermittent and continuous oral administration of calcitriol in dialysis patients; a randomized prospective trial. Nephron 1994; 67: 48-53.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Horandner H.H., Neyer U., Gruber U. et al. Pathomorphology of parathyroid autografts. Nieren Hochdruckkrankheiten 1997; 26: 319-327.</mixed-citation><mixed-citation xml:lang="en">Horandner H.H., Neyer U., Gruber U. et al. Pathomorphology of parathyroid autografts. Nieren Hochdruckkrankheiten 1997; 26: 319-327.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Hsu C.H. Are we mismanaging calcium and phosphate metabolism in renal failure? Am J Kidney Dis 1997; 29: 641-649.</mixed-citation><mixed-citation xml:lang="en">Hsu C.H. Are we mismanaging calcium and phosphate metabolism in renal failure? Am J Kidney Dis 1997; 29: 641-649.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Indridason O.S., Quarles L.D. Comparison of treatments for mild secondary hyperparathyroidism in hemodialysis patients. Kidney Int 2000; 57: 282-292.</mixed-citation><mixed-citation xml:lang="en">Indridason O.S., Quarles L.D. Comparison of treatments for mild secondary hyperparathyroidism in hemodialysis patients. Kidney Int 2000; 57: 282-292.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Islam A., Smogerzewski M., Massry S.G. Effect of verapamil of CRF-induced abnormalities in phospholipid contents of brain synaptosomes. Proc Soc Exp Biol Med 1990; 194: 16-20.</mixed-citation><mixed-citation xml:lang="en">Islam A., Smogerzewski M., Massry S.G. Effect of verapamil of CRF-induced abnormalities in phospholipid contents of brain synaptosomes. Proc Soc Exp Biol Med 1990; 194: 16-20.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Juppner H. Receptors for parathyroid hormone and parathyroid hormone-related peptide: exploration of their biological importance. Bone 1999; 25: 87-90.</mixed-citation><mixed-citation xml:lang="en">Juppner H. Receptors for parathyroid hormone and parathyroid hormone-related peptide: exploration of their biological importance. Bone 1999; 25: 87-90.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Juppner H., Abou Samra A., Freeman M. A G-proteinlinked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 1991; 254: 1024-1026.</mixed-citation><mixed-citation xml:lang="en">Juppner H., Abou Samra A., Freeman M. A G-proteinlinked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 1991; 254: 1024-1026.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Kifor O., Moore F.D., Wang P. еt al. Reduced immunostandartaining for the extracellular Ca-sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab 1996; 81: 1598-1606.</mixed-citation><mixed-citation xml:lang="en">Kifor O., Moore F.D., Wang P. еt al. Reduced immunostandartaining for the extracellular Ca-sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab 1996; 81: 1598-1606.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Klin M., Smogorzewski M., Ni Z. еt al. Abnormalites in hepatic lipase in chronic renal failure: role of excess parathyroid hormone. J Clin Invest 1996; 97: 2167-2173.</mixed-citation><mixed-citation xml:lang="en">Klin M., Smogorzewski M., Ni Z. еt al. Abnormalites in hepatic lipase in chronic renal failure: role of excess parathyroid hormone. J Clin Invest 1996; 97: 2167-2173.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Kurdawa K. The kidney and calcium homeostasis. Kidney Int 1994; 45 (suppl 44): 97-105.</mixed-citation><mixed-citation xml:lang="en">Kurdawa K. The kidney and calcium homeostasis. Kidney Int 1994; 45 (suppl 44): 97-105.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Kuro-oM, Matsumura Y., Aizawa H. еt al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 390: 45-57.</mixed-citation><mixed-citation xml:lang="en">Kuro-oM, Matsumura Y., Aizawa H. еt al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 390: 45-57.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Li Y.C., Amling M., Pirro A.E. et al. Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology 1998; 139: 4391-4396.</mixed-citation><mixed-citation xml:lang="en">Li Y.C., Amling M., Pirro A.E. et al. Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology 1998; 139: 4391-4396.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Llach F., Massry S.G., Singer F.R. Skeletal resistence of endogenus PTH in patients with early renal failure. A possible cause of secondary hyperparathyroidism. J Clin Endocrinol Metab 1975; 44: 1054-1058.</mixed-citation><mixed-citation xml:lang="en">Llach F., Massry S.G., Singer F.R. Skeletal resistence of endogenus PTH in patients with early renal failure. A possible cause of secondary hyperparathyroidism. J Clin Endocrinol Metab 1975; 44: 1054-1058.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Llach F. Hyperphosphatemia in end-stage renal disease patients: pathophysiological consequences. Kidney Int 1999; 73 (Suppl): 31-37.</mixed-citation><mixed-citation xml:lang="en">Llach F. Hyperphosphatemia in end-stage renal disease patients: pathophysiological consequences. Kidney Int 1999; 73 (Suppl): 31-37.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Locatelli F., Cannata-Andia J.B., Drueke T.B. et al. Management of disturbances of calcium and phosphate metabolism in chronic renal insufficiency, with emphasis on the control of hyperphosphataemia. Nephrol Dial Transplant 2002; 17: 723-731.</mixed-citation><mixed-citation xml:lang="en">Locatelli F., Cannata-Andia J.B., Drueke T.B. et al. Management of disturbances of calcium and phosphate metabolism in chronic renal insufficiency, with emphasis on the control of hyperphosphataemia. Nephrol Dial Transplant 2002; 17: 723-731.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Loghman-Adham M. Phosphate binders for control of phosphate retention in chronic renal failure. Pediatr Nephrol 1999; 13: 701-708.</mixed-citation><mixed-citation xml:lang="en">Loghman-Adham M. Phosphate binders for control of phosphate retention in chronic renal failure. Pediatr Nephrol 1999; 13: 701-708.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Lopex-Hilker S., Dusso A.S., Rapp N.S. et al. Phosphorus restriction reverses secondary hyperparathyroidism independent of changes in Ca2+ and calcitriol. Am J Physiol 1990; 259: 432-437.</mixed-citation><mixed-citation xml:lang="en">Lopex-Hilker S., Dusso A.S., Rapp N.S. et al. Phosphorus restriction reverses secondary hyperparathyroidism independent of changes in Ca2+ and calcitriol. Am J Physiol 1990; 259: 432-437.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Marchese A., George S.R., Kolakowski L.F., Lynch K.R., O’Dowd B.F. Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology. Trends Pharmacol Sci 1999; 20: 370-375. [Erratum, Trends Pharmacol Sci 1999; 20: 447.]</mixed-citation><mixed-citation xml:lang="en">Marchese A., George S.R., Kolakowski L.F., Lynch K.R., O’Dowd B.F. Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology. Trends Pharmacol Sci 1999; 20: 370-375. [Erratum, Trends Pharmacol Sci 1999; 20: 447.]</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Marchais S.J., Metivier F., Guerin A., London G. Association of hyperphosphatemia with haemodynamic disturbances in end-stage renal disease. Nephrol Dial Transplant 1999; 14: 2178-2183.</mixed-citation><mixed-citation xml:lang="en">Marchais S.J., Metivier F., Guerin A., London G. Association of hyperphosphatemia with haemodynamic disturbances in end-stage renal disease. Nephrol Dial Transplant 1999; 14: 2178-2183.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Massry S.G. Is parathyroid hormone a uremic toxin? Nephron 1977; 19: 125-130.</mixed-citation><mixed-citation xml:lang="en">Massry S.G. Is parathyroid hormone a uremic toxin? Nephron 1977; 19: 125-130.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Massry S.G. The toxic effect of parathyroid hormone in uremia. Semin Nephrol 1983; 3: 306-328.</mixed-citation><mixed-citation xml:lang="en">Massry S.G. The toxic effect of parathyroid hormone in uremia. Semin Nephrol 1983; 3: 306-328.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Massry S.G., Smogorzewski M. Mechanism through which PTH mediates its deleterious effects on organ function in uremia. Semin Nephrol 1994; 14: 219-231.</mixed-citation><mixed-citation xml:lang="en">Massry S.G., Smogorzewski M. Mechanism through which PTH mediates its deleterious effects on organ function in uremia. Semin Nephrol 1994; 14: 219-231.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Maung H.M., Elangovan L., Frazao J.M. et al. Efficacy and side effects of intermittent intravenous and oral doxercalciferol (1alpha-hydroxyvitamin D2) in dialysis patients with secondary hyperparathyroidism: a sequential comparison. Am J Kidney Dis 2001; 37: 532-543.</mixed-citation><mixed-citation xml:lang="en">Maung H.M., Elangovan L., Frazao J.M. et al. Efficacy and side effects of intermittent intravenous and oral doxercalciferol (1alpha-hydroxyvitamin D2) in dialysis patients with secondary hyperparathyroidism: a sequential comparison. Am J Kidney Dis 2001; 37: 532-543.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">McCarron D.A., Lenfesty B., Narasimhan N., Barry J.M., Vetto R.M., Bennett WM. Anatomical heterogeneity of parathyroid glands in posttransplant hyperparathyroidism. Am J Nephrol 1988; 8: 388-391.</mixed-citation><mixed-citation xml:lang="en">McCarron D.A., Lenfesty B., Narasimhan N., Barry J.M., Vetto R.M., Bennett WM. Anatomical heterogeneity of parathyroid glands in posttransplant hyperparathyroidism. Am J Nephrol 1988; 8: 388-391.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">McCarron D.A., Muther R.S., Lenfesty B., Bennett W.M. Parathyroid function in persistent hyperparathyroidism: relationship to gland size. Kidney Int 1982; 22: 662-670.</mixed-citation><mixed-citation xml:lang="en">McCarron D.A., Muther R.S., Lenfesty B., Bennett W.M. Parathyroid function in persistent hyperparathyroidism: relationship to gland size. Kidney Int 1982; 22: 662-670.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Moallem E., Kilav R., Silver J., Naveh-Many T. RNA-protein binding and post-transcriptional regulation of parathyroid hormone gene expression by calcium and phosphate. J Biol Chem 1998; 273: 5253-5259.</mixed-citation><mixed-citation xml:lang="en">Moallem E., Kilav R., Silver J., Naveh-Many T. RNA-protein binding and post-transcriptional regulation of parathyroid hormone gene expression by calcium and phosphate. J Biol Chem 1998; 273: 5253-5259.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Mucsi I., Hercz G. Relative hypoparathyroidism and adynamic bone disease. Am J Med Sci 1999; 317: 405-409.</mixed-citation><mixed-citation xml:lang="en">Mucsi I., Hercz G. Relative hypoparathyroidism and adynamic bone disease. Am J Med Sci 1999; 317: 405-409.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Malluche H.H., Monier-Faugere M.C. Understanding and managing hyperphosphatemia in patients with chronic renal disease. Clin Nephrol 1999; 52: 267-277.</mixed-citation><mixed-citation xml:lang="en">Malluche H.H., Monier-Faugere M.C. Understanding and managing hyperphosphatemia in patients with chronic renal disease. Clin Nephrol 1999; 52: 267-277.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Naveh-Many T., Rahamimov R., Livni N., Silver J. Parathyroid cell proliferation in normal and chronic renal failure rats: the effects of calcium, phosphate, and vitamin D. J Clin Invest 1995; 96: 1786-1793.</mixed-citation><mixed-citation xml:lang="en">Naveh-Many T., Rahamimov R., Livni N., Silver J. Parathyroid cell proliferation in normal and chronic renal failure rats: the effects of calcium, phosphate, and vitamin D. J Clin Invest 1995; 96: 1786-1793.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Naveh-Many T., Marx R., Keshet E. et al. Regulation of 1,25(OH)2D3 receptor gene expression by 1,25(OH)2D3 in the parathyreoid in vivo. J Clin Invest 86: 1990; 1968-1975.</mixed-citation><mixed-citation xml:lang="en">Naveh-Many T., Marx R., Keshet E. et al. Regulation of 1,25(OH)2D3 receptor gene expression by 1,25(OH)2D3 in the parathyreoid in vivo. J Clin Invest 86: 1990; 1968-1975.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Nygren P., Larsson S., Rastad J., Akerstrom G. 1,25(OH)2D3 inhibits hormone secretion and proliferation but not functional differentiation of cultured bovine parathiroid cells. Calcif Tissue Int 1988; 12: 213-218.</mixed-citation><mixed-citation xml:lang="en">Nygren P., Larsson S., Rastad J., Akerstrom G. 1,25(OH)2D3 inhibits hormone secretion and proliferation but not functional differentiation of cultured bovine parathiroid cells. Calcif Tissue Int 1988; 12: 213-218.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Owda A., Elhwairis H., Narra S., Towery H., Osama S. Secondary hyperparathyroidism in chronic hemodialysis patients: prevalence and race. Ren Fail 2003; 25: 595-602.</mixed-citation><mixed-citation xml:lang="en">Owda A., Elhwairis H., Narra S., Towery H., Osama S. Secondary hyperparathyroidism in chronic hemodialysis patients: prevalence and race. Ren Fail 2003; 25: 595-602.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Parfitt A.M. The hyperparathyroidism of chronic renal failure: a disorder of growth. Kidney Int 1997; 52: 3-9.</mixed-citation><mixed-citation xml:lang="en">Parfitt A.M. The hyperparathyroidism of chronic renal failure: a disorder of growth. Kidney Int 1997; 52: 3-9.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Patel S.R., Ke H.Q. Regulation of calcitriol receptors and its mRNA in normal and renal failure rats. Kidney Int 1994; 45: 1020-1027.</mixed-citation><mixed-citation xml:lang="en">Patel S.R., Ke H.Q. Regulation of calcitriol receptors and its mRNA in normal and renal failure rats. Kidney Int 1994; 45: 1020-1027.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Portale A.A., Halloran B.P., Morris R.C. Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D3 by phosphoreus in normal men. J Clin Invest 1989; 83: 1494-1499.</mixed-citation><mixed-citation xml:lang="en">Portale A.A., Halloran B.P., Morris R.C. Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D3 by phosphoreus in normal men. J Clin Invest 1989; 83: 1494-1499.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Raggi P., Boulay A., Chasan-Taber S. et al. Cardiac calcification in adult hemodialysis patients: a link between end-stage renal disease and cardiovascular disease? J Am Coll Cardiol 2002; 39: 695-701.</mixed-citation><mixed-citation xml:lang="en">Raggi P., Boulay A., Chasan-Taber S. et al. Cardiac calcification in adult hemodialysis patients: a link between end-stage renal disease and cardiovascular disease? J Am Coll Cardiol 2002; 39: 695-701.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Raine A.E.G., Bedford L., Simpson A.W.M. et al. Hyperparathyroidism, platelet intracellular free calcium and hypertension in CRF. Kidney Int 1993; 43: 700-705.</mixed-citation><mixed-citation xml:lang="en">Raine A.E.G., Bedford L., Simpson A.W.M. et al. Hyperparathyroidism, platelet intracellular free calcium and hypertension in CRF. Kidney Int 1993; 43: 700-705.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Reichel H., Drucke T.B., Ritz E. Oxford textbook of clinical nephrology. Second edition. Oxford university press 1998; 1954-1981: 2808.</mixed-citation><mixed-citation xml:lang="en">Reichel H., Drucke T.B., Ritz E. Oxford textbook of clinical nephrology. Second edition. Oxford university press 1998; 1954-1981: 2808.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Ribeiro S., Ramos A., Brandao A. et al. Cardiac valve calcification in haemodialysis patients: role of calcium-phosphate metabolism. Nephrol Dial Transplant 1998; 13: 2037-2040.</mixed-citation><mixed-citation xml:lang="en">Ribeiro S., Ramos A., Brandao A. et al. Cardiac valve calcification in haemodialysis patients: role of calcium-phosphate metabolism. Nephrol Dial Transplant 1998; 13: 2037-2040.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Ritz E., Kuster S., Schmidt-Gayk H. et al. Low-dose calcitriol prevents the rise in 1,84-iPTH without affecting serum calcium and phosphate in patients with moderate renal failure (prospective placebo controlled multicentre trial). Nephrol Dial Transplant 1995; 10: 2228-2234.</mixed-citation><mixed-citation xml:lang="en">Ritz E., Kuster S., Schmidt-Gayk H. et al. Low-dose calcitriol prevents the rise in 1,84-iPTH without affecting serum calcium and phosphate in patients with moderate renal failure (prospective placebo controlled multicentre trial). Nephrol Dial Transplant 1995; 10: 2228-2234.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Ritz E., Stefanski A., Rambausek M. The role of the parathyroid glands in the uremic syndrome. Am J Kidney Dis 1995; 26 (5): 808-813.</mixed-citation><mixed-citation xml:lang="en">Ritz E., Stefanski A., Rambausek M. The role of the parathyroid glands in the uremic syndrome. Am J Kidney Dis 1995; 26 (5): 808-813.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Qing D.P., Ding H., Vadgama J. et al. Elevate myocardial cytosolic calcium impairs insulin-like growth factor-1 stimulated protein syntesis in CRF. J Am Soc Nephrol 1999; 10: 84-92.</mixed-citation><mixed-citation xml:lang="en">Qing D.P., Ding H., Vadgama J. et al. Elevate myocardial cytosolic calcium impairs insulin-like growth factor-1 stimulated protein syntesis in CRF. J Am Soc Nephrol 1999; 10: 84-92.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Salem M.M. Hyperparathyroidism in the hemodialysis population: a survey of 612 patients. Am J Kidney Dis 1997; 29: 862-865.</mixed-citation><mixed-citation xml:lang="en">Salem M.M. Hyperparathyroidism in the hemodialysis population: a survey of 612 patients. Am J Kidney Dis 1997; 29: 862-865.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Salusky I.B., Goodman W.G. Cardiovascular calcification in end-stage renal disease. Nephrol Dial Transplant 2002; 17: 336-339.</mixed-citation><mixed-citation xml:lang="en">Salusky I.B., Goodman W.G. Cardiovascular calcification in end-stage renal disease. Nephrol Dial Transplant 2002; 17: 336-339.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Schomig M., Ritz E. Management of distrurbed calcium metabolism in uremic patients: use of vitamin D metabolites. Nephrol Dial Transplant 2000; 15 (suppl 5): 18-24.</mixed-citation><mixed-citation xml:lang="en">Schomig M., Ritz E. Management of distrurbed calcium metabolism in uremic patients: use of vitamin D metabolites. Nephrol Dial Transplant 2000; 15 (suppl 5): 18-24.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Sherrard D.J., Hercz G., Pei Y. et al. The spectrum of bone disease in end-stage renal failure - an evolving disorder. Kidney Int 1993; 43: 436-442.</mixed-citation><mixed-citation xml:lang="en">Sherrard D.J., Hercz G., Pei Y. et al. The spectrum of bone disease in end-stage renal failure - an evolving disorder. Kidney Int 1993; 43: 436-442.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Silver J., Kilav R., Naveh-Many T. Mechanisms of secondary hyperparathyroidism. Am J Physiol 2002; 283: 367-376.</mixed-citation><mixed-citation xml:lang="en">Silver J., Kilav R., Naveh-Many T. Mechanisms of secondary hyperparathyroidism. Am J Physiol 2002; 283: 367-376.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Silver J., Naweh-Many T., Mayer H. et al. Regulation by vitamin D metabolites of parathyroid gene transcription in vivo in rat. J Clin Invest 1986; 78: 1296-1301.</mixed-citation><mixed-citation xml:lang="en">Silver J., Naweh-Many T., Mayer H. et al. Regulation by vitamin D metabolites of parathyroid gene transcription in vivo in rat. J Clin Invest 1986; 78: 1296-1301.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Silver J., Russel J., Sherwood L.M. Regulation by vitamin D metabolites of mRNA for preproparathyroid hormon in isolated bovine parathyroid cells. Proc Nate Acad Sci 1985; 82: 4270-4273.</mixed-citation><mixed-citation xml:lang="en">Silver J., Russel J., Sherwood L.M. Regulation by vitamin D metabolites of mRNA for preproparathyroid hormon in isolated bovine parathyroid cells. Proc Nate Acad Sci 1985; 82: 4270-4273.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Slatopolsky E., Brown A., Dusso A. Pathogenesis of secondary hyperparathyroidism. Kidney Int Suppl 1999; 73: S14-S19.</mixed-citation><mixed-citation xml:lang="en">Slatopolsky E., Brown A., Dusso A. Pathogenesis of secondary hyperparathyroidism. Kidney Int Suppl 1999; 73: S14-S19.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Slatopolsky E., Brown A., Dusso A. Role of phosphorus in the pathogenesis of secondary hyperparathyroidism. Am J Kidney Dis 2002; 37: 54-57.</mixed-citation><mixed-citation xml:lang="en">Slatopolsky E., Brown A., Dusso A. Role of phosphorus in the pathogenesis of secondary hyperparathyroidism. Am J Kidney Dis 2002; 37: 54-57.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Slatopolsky E., Finch J., Denda M. et al. Phosphorus restriction prevents parathyroid gland growth: high phosphorus directly stimulates PTH secretion in vivo. J Clin Invest 1996; 97: 2534-2540.</mixed-citation><mixed-citation xml:lang="en">Slatopolsky E., Finch J., Denda M. et al. Phosphorus restriction prevents parathyroid gland growth: high phosphorus directly stimulates PTH secretion in vivo. J Clin Invest 1996; 97: 2534-2540.</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Smogorzewski M. PTH, chronic renal failure and myocardium. Miner Electrol Metab 1995; 21: 55-62.</mixed-citation><mixed-citation xml:lang="en">Smogorzewski M. PTH, chronic renal failure and myocardium. Miner Electrol Metab 1995; 21: 55-62.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Smogorzewski M., Koureta P., Fadda G. et al. Chronic parathyroid hormone excess in vivo increases resting levels of cytosolic calcium in brain synaptosomes: studies in the presence and absence of chronic renal failure. L Amer Soc Nephrol 1991; 1: 1162-1168.</mixed-citation><mixed-citation xml:lang="en">Smogorzewski M., Koureta P., Fadda G. et al. Chronic parathyroid hormone excess in vivo increases resting levels of cytosolic calcium in brain synaptosomes: studies in the presence and absence of chronic renal failure. L Amer Soc Nephrol 1991; 1: 1162-1168.</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Solal M.-E.C., Sebert J.-L., Boudailliez B. et al. Comparison of intact, midregion, and carboxy terminal assays of parathyroid hormone for the diagnosis of bone disease in hemodialyzed patients. J Clin Endocrinol Metab 1991; 73: 516-524.</mixed-citation><mixed-citation xml:lang="en">Solal M.-E.C., Sebert J.-L., Boudailliez B. et al. Comparison of intact, midregion, and carboxy terminal assays of parathyroid hormone for the diagnosis of bone disease in hemodialyzed patients. J Clin Endocrinol Metab 1991; 73: 516-524.</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Strewler G.J. The physiology of parathyroid hormone-related protein. N Engl J Med 2000; 342: 177-185.</mixed-citation><mixed-citation xml:lang="en">Strewler G.J. The physiology of parathyroid hormone-related protein. N Engl J Med 2000; 342: 177-185.</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Thenmin N., Smogorzewski M., Massry S.G. Derangements in acetylcholine metabolism in brain synaptosomes in CRF. Kidney Int 1993; 44: 630-637.</mixed-citation><mixed-citation xml:lang="en">Thenmin N., Smogorzewski M., Massry S.G. Derangements in acetylcholine metabolism in brain synaptosomes in CRF. Kidney Int 1993; 44: 630-637.</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Thomas L., Clemens P.D. Cardiovascular biology of the parathyroid hormone-related proteins. Endocrinology of cardiovascular function. Ed. By Ellis R., Levin A., Terry L. Kluwer Academic Publishers. Boston (Dordrecht) London: 1998: 237-254.</mixed-citation><mixed-citation xml:lang="en">Thomas L., Clemens P.D. Cardiovascular biology of the parathyroid hormone-related proteins. Endocrinology of cardiovascular function. Ed. By Ellis R., Levin A., Terry L. Kluwer Academic Publishers. Boston (Dordrecht) London: 1998: 237-254.</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Tian J., Smogorzewski M., Kedes L., Massry S.G. PTH - PTHrP receptors mRNA in downregulated in chronic renal failure. Am J Nephrol 1994; 14: 41-46.</mixed-citation><mixed-citation xml:lang="en">Tian J., Smogorzewski M., Kedes L., Massry S.G. PTH - PTHrP receptors mRNA in downregulated in chronic renal failure. Am J Nephrol 1994; 14: 41-46.</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Tominaga Y., Kohara S., Namii Y. et al. Clonal analysis of nodular hyperplasia in renal hyperparathyroidism. World J Surg 1996; 20: 744-752.</mixed-citation><mixed-citation xml:lang="en">Tominaga Y., Kohara S., Namii Y. et al. Clonal analysis of nodular hyperplasia in renal hyperparathyroidism. World J Surg 1996; 20: 744-752.</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Tominaga Y., Tanaka Y., Sato K., Nagasaka T., Takagi H. Histology, pathophysiology, and indications for surgical treatment of renal hyperparathyroidism. Semin Surg Oncol 1997; 13: 78-86.</mixed-citation><mixed-citation xml:lang="en">Tominaga Y., Tanaka Y., Sato K., Nagasaka T., Takagi H. Histology, pathophysiology, and indications for surgical treatment of renal hyperparathyroidism. Semin Surg Oncol 1997; 13: 78-86.</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Usdin T.B., Hoare S.R.J., Wang T., Mezey E., Kowalak J.A. TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus. Nat Neurosci 1999; 2: 941-943.</mixed-citation><mixed-citation xml:lang="en">Usdin T.B., Hoare S.R.J., Wang T., Mezey E., Kowalak J.A. TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus. Nat Neurosci 1999; 2: 941-943.</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Wielen R.P., Lowik M.R., van den Berg H. еt al. Serum vitamin D concentrations among elderly people in Europe. Lancet 1995; 346: 207-210.</mixed-citation><mixed-citation xml:lang="en">Van der Wielen R.P., Lowik M.R., van den Berg H. еt al. Serum vitamin D concentrations among elderly people in Europe. Lancet 1995; 346: 207-210.</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">Wang R., Karpinski E., Pang P.K. Parathyroid hormone selectively inhibits L-type calcium channels in single vascular smooth muscle cells of the rat. J Physiol 1991; 441: 325-346.</mixed-citation><mixed-citation xml:lang="en">Wang R., Karpinski E., Pang P.K. Parathyroid hormone selectively inhibits L-type calcium channels in single vascular smooth muscle cells of the rat. J Physiol 1991; 441: 325-346.</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">Weisinger J.R., Fafus M.J., Langman C.B. et al. Regulation of 1,25-dihydroxyvitamin D3 by calcium in the parathyroidectomized parathyroid hormone - replete rat. J Bone Miner Res 1989; 4: 929-935.</mixed-citation><mixed-citation xml:lang="en">Weisinger J.R., Fafus M.J., Langman C.B. et al. Regulation of 1,25-dihydroxyvitamin D3 by calcium in the parathyroidectomized parathyroid hormone - replete rat. J Bone Miner Res 1989; 4: 929-935.</mixed-citation></citation-alternatives></ref><ref id="cit101"><label>101</label><citation-alternatives><mixed-citation xml:lang="ru">Yoshida T., Fujimori T., Nabeshima Y. Mediation of unusually high concentrations of 1,25-dihydroxyvitami D in homozygous klotho mutant mice by incression of renal 1alpha-hydroxylase gene. Endocrinology 2002; 13: 683-689.</mixed-citation><mixed-citation xml:lang="en">Yoshida T., Fujimori T., Nabeshima Y. Mediation of unusually high concentrations of 1,25-dihydroxyvitami D in homozygous klotho mutant mice by incression of renal 1alpha-hydroxylase gene. Endocrinology 2002; 13: 683-689.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
