nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-1976Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESРоль оксидативного стресса в патологии сердечно-сосудистой системы у больных с заболеваниями почек (Сообщение II. Клинические аспекты оксидативного стресса)The impact of oxidative stress on cardiovascular pathology in patients with kidney diseases (Part II. Clinical aspects of oxidative stress)СаенкоЮ. В.SaenkoYu. V.noemail@neicon.ruШутовА. М.ShutovA. M.amshu@mail.ruКафедра экспериментально-клинической фармакологии и биохимии и кафедра терапии и профессиональных болезней Ульяновского государственного университета, УльяновскRussian Federation20042706202562138144Copyright © Саенко Ю.В., Шутов А.М., 20252025Саенко Ю.В., Шутов А.М.Saenko Y.V., Shutov A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/1976

Причиной возникновения оксидативного стресса является увеличение продукции свободных радикалов и (или) снижение эффективности антиоксидантных систем организма. Сообщение II касается клинических аспектов оксидативного стресса у больных с патологией почек. Представлены данные о связи оксидативного стресса с эндотелиальной дисфункцией, анемией, атеросклерозом. Обобщены данные литературы об оксидативном стрессе у больных с ХПН, получающих заместительную терапию. Приведены данные о влиянии ингибиторов АПФ, статинов, витамина Е на перекисное окисление липидов у больных заболеваниями почек. * Часть I данного сообщения опубликована в журнале «Нефрология и диализ» 2004; т. 6; № 1

Oxidative stress is a disbalance between oxidant and antioxidant systems in body. Many kidney diseases are accompanied by oxidative stress. In the present review (part II) we discuss relationship between oxidative stress, endothelial dysfunction, anemia and atherosclerosis. The impact of ACE-inhibitors, statins and vitamin E on oxidant and antioxidant status of patients with chronic kidney disease are consireted. An intensification of oxidative stress during replacement therapy is discussed.

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The authors declare that there are no conflicts of interest present.