nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-1986Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESКостное ремоделирование как модель межклеточных взаимодействий (Обзор литературы)Bone remodeling as model of intercellular actionsКартамышеваН. Н.KartamyshevaN. N.noemail@neicon.ruЧумаковаО. В.TchumakovaO. V.noemail@neicon.ruНИИ педиатрии НЦЗД РАМН, г. МоскваRussian Federation200427062025614346Copyright © Картамышева Н.Н., Чумакова О.В., 20252025Картамышева Н.Н., Чумакова О.В.Kartamysheva N.N., Tchumakova O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/1986

Костное ремоделирование - сложно регулируемый процесс, в основе которого лежит взаимодействие двух клеточных линий: остеобластов, обеспечивающих образование кости, и остеокластов, разрушающих костную ткань. В генезе образования и резорбции кости в физиологических и патологических условиях значительная роль принадлежит многогранным межклеточным взаимодействиям, опосредованным влиянием множества цитокинов и факторов роста, в частности интерлейкина-1 и членов семейства фактора некроза опухоли и его рецептора. Последние исследования генеза костного ремоделирования расширяют представление о механизмах костного повреждения, результатом которых, возможно, окажется выявление новых подходов к диагностике и лечению патологического процесса в кости, который является частой и серьезной клинической проблемой.

Bone remodeling is a complex regulated process consisting of intercellular action of two cell lines: osteoblasts providing bone formation and osteoclasts critical cells for bone resorption. Cytokines and growth factors particularly interleukin-1, members of TNF-superfamily and TNF-receptor superfamily play an important role in this process. Emerging date on the genesis of bone remodeling are redefining our understanding of the mechanisms of bone damage. New observations regarding maneuvers that downregulate such injurious bone responses may direct further studies that develop new diagnostic and therapeutic modalities.

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The authors declare that there are no conflicts of interest present.