References

nid

Нефрология и диализ

Nephrology and Dialysis

1680-44222618-9801

Российское диализное общество

nid-3115

Research Article

ОБЗОРЫ И ЛЕКЦИИ

REVIEWS AND LECTURES

Волчаночный гломерулонефрит: клиника, морфология, прогно

Lupus glomerulonephritis: clinical features, morphology and prognosis

Захарова

Е. В.

Zakharova

E. V.

noemail@neicon.ru

Московская городская клиническая больница им. С.П. БоткинаRussian Federation

2003

27062025

52116122

2025

Захарова Е.В.

Zakharova E.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.nephro.ru/jour/article/view/3115

Волчаночный гломерулонефрит (ВГН) является одним из серьезных и прогностически значимых проявлений системной красной волчанки (СКВ) [9, 18]. Механизм развития люпус-нефрита иммунокомплексный. В основе патогенеза лежит обусловленный генетически дефект апоптоза аутореактивных клонов Т- и В-клеток, приводящий к активации поликлональных В-лимфоцитов и формированию Т-зависимого иммунного ответа на аутоантигены - ДНК и нуклеосомы. Связывание антител к ДНК и других аутоантител с базальной мембраной почечных клубочков ведет к активации комплемента и рекрутированию клеток воспаления в клубочек [7, 18, 23, 28, 30, 33, 52, 63, 65, 67].

системная красная волчанкаволчаночный гломерулонефритпрогнозклиникаморфология

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The authors declare that there are no conflicts of interest present.