nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-3191Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESХроническая трансплантационная нефропатия: механизмы развития и факторы прогрессирования (Обзор литературы, часть 2)Chronic allograft nephropathy: mechanisms of pathogenesis and progression factorsСтоляревичЕ. С.StolyarevichE. S.noemail@neicon.ruНИИ трансплантологии и искусственных органов МЗ РФ, г. МоскваRussian Federation200228062025429397Copyright © Столяревич Е.С., 20252025Столяревич Е.С.Stolyarevich E.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/3191

Факторы, влияющие на скорость прогрессирования хронической трансплантационной нефропатии (ХТН) Артериальная гипертония как фактор прогрессирования ХТН В литературе последних лет все более утверждается точка зрения о важной роли системной артериальной гипертензии (АГ) в механизме развития и прогрессирования гломерулосклероза [5, 22, 36, 97, 101]. Взаимосвязь между системной АГ и внутриклубочковой гипертонией при поражениях собственных почек не вызывает сомнений. Она объясняется тем, что при длительно существующей АГ за счет истощения компенсаторных механизмов, регулирующих тонус приносящей и уносящей артериол, происходит передача повышенного гидростатического давления на капилляры клубочка [5, 56, 76, 101, 117]. Следствием возрастающего внутриклубочкового давления является дальнейшее ускоренное прогрессирование нефропатии.

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The authors declare that there are no conflicts of interest present.