В результате трехлетнего проспективного исследования 90 пациентов с различными урологическими заболеваниями установлено, что гиперфильтрация, снижение функционального почечного резерва являются предвестником скорого развития почечной недостаточности. Гемодинамические механизмы прогрессирования нефросклероза ответственны за развитие почечной недостаточности при урологических нефропатиях, как и при гломерулярных болезнях.
Three-year prospective follow-up of patients (n = 90) with various urologic diseases was aimed at the revealing early manifestations of the deteriorated renal function. The initial nitrogen-excretory renal function was normal in every patient. The start point for assigning the patient to the examined group was the high risk of renal failure occurrence. Early in the study, 9 of 12 patients with urolithiasis displayed microalbuminuria or proteinuria outside the periods of active urinary infection and the obstruction of urinary tracts; the functional renal reserve (FRR) was decreased. In 3 years, in 7 of those patients uremia was detected. In patients with the sole kidney pathology, polycystic kidney, the findings proved that FRR lowering and hyperfiltration precede the developement of renal failure in urologic and glomerular diseases.
The authors declare that there are no conflicts of interest present.