nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-3286Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESИспользование плазмафереза для коррекции реперфузионной травмы при пересадке почкиCorrection of ischemia/reperfusion injury with plasmapheresis in kidney transplantationКаабакМ. М.KaabakM. M.gautier@mail.med.ruГоряйновВ. А.GoriainovV. A.noemail@neicon.ruДьяченкоИ. В.DyachenkoI. V.noemail@neicon.ruОтдел трансплантации органов Российского научного центра хирургии РАМН, отделение трансплантации почки и экстракорпоральных методов лечения Российской детской клинической больницы МЗ РФ, МоскваRussian Federation20012806202533345353Copyright © Каабак М.М., Горяйнов В.А., Дьяченко И.В., 20252025Каабак М.М., Горяйнов В.А., Дьяченко И.В.Kaabak M.M., Goriainov V.A., Dyachenko I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/3286

Для профилактики реперфузионной травмы у 32 пациентов в течение первых 4 часов после реперфузии почечного аллотрансплантата был проведен сеанс плазмафереза. Оценивались частота отсроченной функции трансплантата, актуариальная выживаемость трансплантатов и пациентов, а также удельный прирост креатинина (мкмоль/л/сут). Полученные результаты сравнивались с двумя контрольными группами: 32 пациента, оперированных до начала исследования, и 31 пациент, оперированный после завершения исследования. Продемонстрировано существенное уменьшение доли трансплантатов с отсроченной функцией и улучшение отдаленных результатов в группе больных, получивших плазмаферез.

To evaluate an efficacy of plasmapheresis in prevention of ischemia/reperfusion injury we compared the incidence of delayed graft function, as well as long-term results in 32 patients, received plasmapheresis within first 4 hours after graft reperfusion with historic controls (32 patients transplanted before starting of investigated group and 31 patients transplanted after the investigated group was completed). Graft function was considered as delayed if patient received at least two dialysis during first week after transplantation. To compare long term results, actuarial patient and graft survival were calculated and degree of serum creatinine rising was estimated (as micromol/liter/day). Significant reduction of delayed graft function and improved long-term results in investigated group are demonstrated and discussed.

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The authors declare that there are no conflicts of interest present.