References

nid

Нефрология и диализ

Nephrology and Dialysis

1680-44222618-9801

Российское диализное общество

10.28996/2618-9801-2018-2-150-169

nid-333

Research Article

ОБЗОРЫ И ЛЕКЦИИ

REVIEWS AND LECTURES

Роль почек в поддержании кальциевого и магниевого гомеостаза и при его нарушениях (Часть I)

Role of kidney in maintaining calcium and magnesium homeostasis and its disorders (Part I)

Зверев

Я. Ф.

Zverev

Ja. F.

zver@agmu.ru

Брюханов

В. М.

Bryukhanov

V. M.

noemail@neicon.ru

Рыкунова

А. Я.

Rykunova

A. Ya.

noemail@neicon.ru

ГБОУ ВПО "Алтайский государственный медицинский университет" Минздрава РФРоссияAltai state medical UniversityRussian Federation

КГБУЗ "Краевая клиническая больница" Минздрава РФРоссияAltai regional clinical HospitalRussian Federation

2018

12082024

202150169

2024

Зверев Я.Ф., Брюханов В.М., Рыкунова А.Я.

Zverev J.F., Bryukhanov V.M., Rykunova A.Y.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.nephro.ru/jour/article/view/333

Обзор посвящен проблеме кальциевого и магниевого гомеостаза и его регуляции в организме человека. С учетом последних достижений молекулярной биологии рассматривается процесс пассивного и активного переноса Ca2+ и Mg2+ в различных органах, сложные процессы регуляции их кишечной абсорбции, костной минерализации, передвижения в различных отделах почки. Обсуждается роль клаудинов в обеспечении транспорта двухвалентных катионов в толстом восходящем отделе петли Генле. Рассматриваются особенности топологи клаудинов, обусловливающие функционирование плотных межклеточных контактов в канальцах почек и их значение для процесса парацеллюлярной реабсорбции Ca2+ и Mg2+. Описывается роль каналов семейства TRP в реабсорбции Ca2+ и Mg2+ в дистальных извитых канальцах. Подчеркивается особая роль каналов TRPV5 и TRPV6 в активном трансцеллюлярном переносе этих катионов, что имеет важное значение в регуляции кальциевого и магниевого гомеостаза. Приводятся современные взгляды на топологию и функциональное значение кальций-чувствительных рецепторов, локализованных в паращитовидных железах и нефроне, в регуляции внеклеточного уровня двухвалентных катионов. Отмечается появление агонистов и антагонистов кальций-чувствительных рецепторов и их потенциальная роль в коррекции нарушений кальциевого обмена. Обсуждаются вопросы регуляции почечного транспорта Ca2+ и Mg2+.

The review is devoted to the problem of calcium and magnesium homeostasis and its regulation in the human body. Taking into account the latest achievements of molecular biology, the process of passive and active transport of Ca2+ and Mg2+ in the intestine, bones and renal tubules is considered. The role of claudine in the transport of divalent cations in the thick ascending limb of the Henle loop is discussed. The peculiarities of the topology of claudins are considered, which determine the functioning of dense intercellular contacts in the renal tubules and their significance for the process of paracellular reabsorption of Ca2+ and Mg2+. The role of the TRP family channels in the reabsorption of Ca2+ and Mg2+ in the distal nephron is described. The special role of TRPV5 and TRPV6 channels in the active transcellular transfer of these cations, which is of great importance in the regulation of calcium and magnesium homeostasis, is emphasized. Modern views on the role of calcium-sensitive receptors in the regulation of the extracellular level of divalent cations are given. Issues of regulation of renal transport of Ca2+ and Mg2+ are discussed.

гомеостаз кальция и магнияпочечный транспортклаудиныканалы семейства TRPкальций-чувствительный рецепторcalcium and magnesium homeostasisrenal transportclaudineTRP family channelscalcium-sensitive receptor

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The authors declare that there are no conflicts of interest present.