nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-3729Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESВыбор оптимального режима терапии Циклоспорином у реципиентов аллогенных почек в различные сроки после операцииA choice of optimal regimen for cicposporine-therapy in recipients of allogenic kidneys at different peropds after the operationКаабакМ. М.KaabakM. M.gautier@mail.med.ruГоряйновВ. А.GoriainovV. A.noemail@neicon.ruАгурееваЛ. И.AgureevaL. I.noemail@neicon.ruВинницкийЛ. И.VinnitskyL. I.noemail@neicon.ruВоробьеваН. Т.VorobievaN. T.noemail@neicon.ruОтдел трансплантации органов, Лаборатория клинической иммунологии Российского Научного Центра Хирургии РАМНRussian Federation200128062025315760Copyright © Каабак М.М., Горяйнов В.А., Агуреева Л.И., Винницкий Л.И., Воробьева Н.Т., 20252025Каабак М.М., Горяйнов В.А., Агуреева Л.И., Винницкий Л.И., Воробьева Н.Т.Kaabak M.M., Goriainov V.A., Agureeva L.I., Vinnitsky L.I., Vorobieva N.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/3729

У 54 реципиентов аллогенных почек (28 мужчин и 26 женщин в возрасте 6-49 лет) для оценки адекватности терапии Циклоспорином определяли Т-0, Т-1, Т-3 и вычисляли AUC (area under the curve). Срок наблюдения - 3-3056 дней после операции. Полученные данные были подвергнуты статистической обработке и корреляционному анализу. Математический анализ показал, что корреляция между дозой Сандиммуна и перечисленными показателями довольно вариабельна (r = 0,2878-0,5765). Наибольшая корреляция наблюдалась между Т-3, AUC и дозой Сандиммуна. Следовательно: именно на эти параметры следует ориентироваться при коррекции дозы Сандиммуна.

To evaluate an adequacy of Cyclosporine-therapy in 54 recipients of allogenic kidneys (28 males and 26 females aged 6-49 years) were examined T-0, T-1, T-3 with AUC (area under the curve) calculation. All the patients were from 3 to 3056 days after the operation. All received data were exposed to statistic analysis with determination of a correlation degree. A mathematic analysis revealed that a correlation between CyA-dose and these parameters is very various (r = 0.2878-0.5765). CyA-dose most closely correlated with T-3 and AUC (r = 0.5554-0.5765). Therefore, for correcting CyA-dose we should be oriented on T-3 and AUC.

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The authors declare that there are no conflicts of interest present.