nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-434Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESПрогнозирование результатов трансплантации почки по факторам, связанным с состоянием пациентов до операции Часть 2 - Результаты многофакторного анализаPredicting the results of kidney transplantation by factors associated with the condition of patients before surgery Part 2 - The results of multivariate analysisСтолярА. Г.StolyarA. G.ambr375@mail.ruБудкарьЛ. Н.BudkarL. N.noemail@neicon.ruСолодушкинС. И.SolodushkinS. I.noemail@neicon.ruГБУЗ СО «Свердловская областная клиническая больница №1»РоссияRegional Clinical Hospital №1 EkaterinburgRussian FederationФБУН «Екатеринбургский медицинский научный центр профилактики и охраны здоровья рабочих промпредприятий» ПОЗРПП РоспотребнадзораРоссияFBSI «Ekaterinburg medical scientific centre of prophylaxis and protection of health by the workers of industry enterprises» Russian consumers’ supervisionRussian FederationУральский федеральный университет; Институт математики и механики Уральского отделения Российской академии наукРоссияUral Federal University; Ural Branch of the Russian Academy of SciencesRussian Federation201619082024182199207Copyright © Столяр А.Г., Будкарь Л.Н., Солодушкин С.И., 20242024Столяр А.Г., Будкарь Л.Н., Солодушкин С.И.Stolyar A.G., Budkar L.N., Solodushkin S.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/434

Цель исследования, материал и методы описаны в части 1. Результаты. Методами многофакторного анализа выявлены следующие значимые предикторы результатов АТП, связанные с состоянием пациента до операции (р<0,05). Для жизни пациента: гемоглобин, альбумин, АЛТ, холестерин, курение. Для РАТ: гемоглобин, альбумин, курение. Для развития хронической трансплантационной нефропатии: курение, гемоглобин, АЛТ, индекс коморбидности.

The aim of the study, materials and methods are described in the first part of the article. Results: Methods of multivariate analysis revealed the following significant predictors of ATP results associated with the condition of the patient before the surgery (р<0,05): for the life of the patient: hemoglobin level, albumin, ALT, cholesterol, smoking; for renal transplant: hemoglobin level, albumin, smoking; for chronic transplant nephropathy: smoking, hemoglobin level, ALT, comorbidity index.

результаты трансплантации почкиренальный аллотрансплантатпрогнозированиеоднофакторный анализвыживаемостьпотеря трансплантатахроническая трансплантационная нефропатияresults of kidney transplantationpredictingrenal allotransplantmultivariate analysissurvivalgraft losschronic transplant nephropathyReferencesАндрусев А.М., Титова Н.Л., Бикбов Б.Т., Томилина Н.А. Перитонеальный диализ: ранние предикторы отдаленных результатов. Нефрология и диализ. 2003. Т. 5. №4: 362-368.Андрусев А.М., Титова Н.Л., Бикбов Б.Т., Томилина Н.А. Перитонеальный диализ: ранние предикторы отдаленных результатов. Нефрология и диализ. 2003. Т. 5. №4: 362-368.Бикбов Б.Т., Кирхман В.В., Ушакова А.И., Камшилова Н.И., Томилина Н.А. Предикторы летального исхода у больных на гемодиализе. Нефрология и диализ. 2004. Т. 6. №2: 154 - 163.Бикбов Б.Т., Кирхман В.В., Ушакова А.И., Камшилова Н.И., Томилина Н.А. Предикторы летального исхода у больных на гемодиализе. Нефрология и диализ. 2004. Т. 6. №2: 154 - 163.Волгина Г.В., Перепеченных Ю.В., Бикбов Б.Т., и соавт. Факторы риска кардиваскулярных заболеваний у больных с хронической почечной недостаточностью. Нефрология и диализ. 2000. Т. 2. №4: 252-259.Волгина Г.В., Перепеченных Ю.В., Бикбов Б.Т., и соавт. Факторы риска кардиваскулярных заболеваний у больных с хронической почечной недостаточностью. Нефрология и диализ. 2000. Т. 2. №4: 252-259.Новикова Н.А., Гендлин Г.Е., Сторожаков Г.И., Томилина Н.А., Андрусев А.М. Выживаемость больных хронической терминальной почечной недостаточностью, получающих постоянный амбулаторный перитонеальный диализ. Клиническая нефрология. 2010. №4: 26-33.Новикова Н.А., Гендлин Г.Е., Сторожаков Г.И., Томилина Н.А., Андрусев А.М. Выживаемость больных хронической терминальной почечной недостаточностью, получающих постоянный амбулаторный перитонеальный диализ. Клиническая нефрология. 2010. №4: 26-33.Arnol M., Buturović-Ponikvar J., Kandus A. Association of Pretransplant Renal Replacement Therapy Duration With Outcome in Kidney Transplant Recipients: A Prevalent Cohort Study in Slovenia. Therapeutic Apheresis and Dialysis. DOI: 10.1111/j.1744-9987.2011.00943.x.Arnol M., Buturović-Ponikvar J., Kandus A. Association of Pretransplant Renal Replacement Therapy Duration With Outcome in Kidney Transplant Recipients: A Prevalent Cohort Study in Slovenia. Therapeutic Apheresis and Dialysis. DOI: 10.1111/j.1744-9987.2011.00943.x.Bittar J., Cepeda P., de la Fuente J., et al. Renal transplantation in diabetic patients. Transplant Proc. 2006. Apr. 38(3): 895-8.Bittar J., Cepeda P., de la Fuente J., et al. Renal transplantation in diabetic patients. Transplant Proc. 2006. Apr. 38(3): 895-8.Boucek P., Saudek F., Pokorna E., et al. Kidney transplantation in type 2 diabetic patients: a comparison with matched non-diabetic subjects. Nephrol Dial Transplant. 2002. 17: 1678-1683.Boucek P., Saudek F., Pokorna E., et al. Kidney transplantation in type 2 diabetic patients: a comparison with matched non-diabetic subjects. Nephrol Dial Transplant. 2002. 17: 1678-1683.Doyle S.E., Matas A.J., Gillingham K. and Rosenberg M.E. Predicting clinical outcome in the elderly renal transplant recipient. Kidney International. 2000. 57: 21442150; doi:10.1046/j.1523-1755.2000.00066.x.Doyle S.E., Matas A.J., Gillingham K. and Rosenberg M.E. Predicting clinical outcome in the elderly renal transplant recipient. Kidney International. 2000. 57: 21442150; doi:10.1046/j.1523-1755.2000.00066.x.Faravardeh A., Eickhoff M., Jackson S., et al. Predictors of graft failure and death in elderly kidney transplant recipients. Transplantation. 2013. 96. 12: 1089-1096.Faravardeh A., Eickhoff M., Jackson S., et al. Predictors of graft failure and death in elderly kidney transplant recipients. Transplantation. 2013. 96. 12: 1089-1096.Foley D.P., Patton P.R., Meier-Kriesche H.U et al. Long-term outcomes of kidney transplantation in recipients 60 years of age and older at the University of Florida. Clin Transpl. 2005: 101-9. http://www.ncbi.nlm.nih.gov/pubmed/.Foley D.P., Patton P.R., Meier-Kriesche H.U et al. Long-term outcomes of kidney transplantation in recipients 60 years of age and older at the University of Florida. Clin Transpl. 2005: 101-9. http://www.ncbi.nlm.nih.gov/pubmed/.Kasiske B.L., Gaston R.S., Gourishankar S., et. al. Long-term deterioration of kidney allograft function. Am J Transplant. 2005. 5: 1405-1414.Kasiske B.L., Gaston R.S., Gourishankar S., et. al. Long-term deterioration of kidney allograft function. Am J Transplant. 2005. 5: 1405-1414.Kasiske B.L., Klinger D. Cigarette smoking in renal transplant recipients. J Am Soc Nephrol. 2000. 11: 753-759.Kasiske B.L., Klinger D. Cigarette smoking in renal transplant recipients. J Am Soc Nephrol. 2000. 11: 753-759.Kaysen G.A., Dubin J.A., Müller H-G., et al. Inflammation and reduced albumin synthesis associated with stable decline in serum albumin in hemodialysis patients. Kidney International. 65. №4: 1408-1415.Kaysen G.A., Dubin J.A., Müller H-G., et al. Inflammation and reduced albumin synthesis associated with stable decline in serum albumin in hemodialysis patients. Kidney International. 65. №4: 1408-1415.Lai X., Chen G., Qiu J., Wang C., Lizhong C. Recipient-Related Risk Factors for Graft Failure and Death in Elderly Kidney Transplant Recipients. PLOS. Published: November 12. 2014. DOI: 10.1371.Lai X., Chen G., Qiu J., Wang C., Lizhong C. Recipient-Related Risk Factors for Graft Failure and Death in Elderly Kidney Transplant Recipients. PLOS. Published: November 12. 2014. DOI: 10.1371.London G.M., Pannier B., Guerin A.P. at al. Alterations of left ventricular hypertrophy in and survival of patients receiving hemodialysis: follow-up of an interventional study. J Am Soc Nephrol. 2001 Dec. 12(12): 2759-67.London G.M., Pannier B., Guerin A.P. at al. Alterations of left ventricular hypertrophy in and survival of patients receiving hemodialysis: follow-up of an interventional study. J Am Soc Nephrol. 2001 Dec. 12(12): 2759-67.Lowrie E.G., Lew N.L. Death risk in hemodialysis patients: The predictive value of commonly measured variables and an evaluation of death rate differences between facilities. Am J Kidney Dis. 1990. 15: 458-482.Lowrie E.G., Lew N.L. Death risk in hemodialysis patients: The predictive value of commonly measured variables and an evaluation of death rate differences between facilities. Am J Kidney Dis. 1990. 15: 458-482.Mann J.F.E. What are the short-term and long-term consequences of anemia in CRF patients? Nephrol Dial Transplant. 1999. 14 (Suppl 2): 29-36.Mann J.F.E. What are the short-term and long-term consequences of anemia in CRF patients? Nephrol Dial Transplant. 1999. 14 (Suppl 2): 29-36.Ojo A.O., Hanson J.A., Wolfe R.A., Leichtman A.B., Agodoa L.Y. and Port F.K. Long-term survival in renal transplant recipients with graft function. Kidney International.2000. 57, 307-313; doi:10.1046/j.1523-1755.2000.00816.x.Ojo A.O., Hanson J.A., Wolfe R.A., Leichtman A.B., Agodoa L.Y. and Port F.K. Long-term survival in renal transplant recipients with graft function. Kidney International.2000. 57, 307-313; doi:10.1046/j.1523-1755.2000.00816.x.Orth S.R., Ogata H., Ritz E. Smoking and the kidney. Nephrology Dialysis Transplantation. 15. 10: 1509-1511.Orth S.R., Ogata H., Ritz E. Smoking and the kidney. Nephrology Dialysis Transplantation. 15. 10: 1509-1511.Orth S.R., Schreier R.W., Ritz E. The renal risks of smoking. Kidney Int. 1997. 51: 1669-1677.Orth S.R., Schreier R.W., Ritz E. The renal risks of smoking. Kidney Int. 1997. 51: 1669-1677.Sameiro-Faria M., Ribeiro S., Costa E., et al. Risk Factors for Mortality in Hemodialysis Patients: Two-Year Follow-Up Study. Disease Markers. 2013. 35. 6: 791-798. http://dx.doi.org/10.1155/2013/518945.Sameiro-Faria M., Ribeiro S., Costa E., et al. Risk Factors for Mortality in Hemodialysis Patients: Two-Year Follow-Up Study. Disease Markers. 2013. 35. 6: 791-798. http://dx.doi.org/10.1155/2013/518945.Silberberg J.S., Barre P.E., Prichard S.S., Sniderman A.D. Impact of left ventricular hypertrophy on survival in end-stage renal disease. Kidney Int. 1989 Aug. 36(2): 286-90.Silberberg J.S., Barre P.E., Prichard S.S., Sniderman A.D. Impact of left ventricular hypertrophy on survival in end-stage renal disease. Kidney Int. 1989 Aug. 36(2): 286-90.Silberberg J.S., Rahal D.P., Patton R., Sniderman A.D. Role of anemia in the pathogenesis of left ventricular hypertrophy in end-stage renal disease. Am J Cardiol. 1989. № 64: 222-224.Silberberg J.S., Rahal D.P., Patton R., Sniderman A.D. Role of anemia in the pathogenesis of left ventricular hypertrophy in end-stage renal disease. Am J Cardiol. 1989. № 64: 222-224.Thorp M.L., Johnson E.S., Yang X., et al. Effect of anemia on mortality, cardiovascular hospitalizations and end-stage renal disease among patients with chronic kidney disease. Nephrology (Carlton). 2009. 14 (№ 2): P. 240-6.Thorp M.L., Johnson E.S., Yang X., et al. Effect of anemia on mortality, cardiovascular hospitalizations and end-stage renal disease among patients with chronic kidney disease. Nephrology (Carlton). 2009. 14 (№ 2): P. 240-6.Wang W., Li X.B., Yin H., et al. Factors affecting the long-term renal allograft survival. Chinese Medical Journal. 2011. 124. 8: 1181-1184.Wang W., Li X.B., Yin H., et al. Factors affecting the long-term renal allograft survival. Chinese Medical Journal. 2011. 124. 8: 1181-1184.Weiner D.E., Tighiouart H., Vlagopoulos P.T., et al. Effects of Anemia and Left Ventricular Hypertrophy on Cardiovascular Disease in Patients with Chronic Kidney Disease. J Am Soc Nephrol. 2005. № 16: 1803-1810.Weiner D.E., Tighiouart H., Vlagopoulos P.T., et al. Effects of Anemia and Left Ventricular Hypertrophy on Cardiovascular Disease in Patients with Chronic Kidney Disease. J Am Soc Nephrol. 2005. № 16: 1803-1810.Zoccali C., Benedetto F.A., Mallamaci F., et al. Left ventricular mass monitoring in the follow-up of dialysis patients: Prognostic value of left ventricular hypertrophy progression. Kidney Int. 2004. 65: 1492-1498.Zoccali C., Benedetto F.A., Mallamaci F., et al. Left ventricular mass monitoring in the follow-up of dialysis patients: Prognostic value of left ventricular hypertrophy progression. Kidney Int. 2004. 65: 1492-1498.http://newsnetwork.mayoclinic.org/discussion/mayo-clinic-study-shows-5-year-survival-of-diabetes-and-non-diabetes-patients-post-kidney-transplant/.http://newsnetwork.mayoclinic.org/discussion/mayo-clinic-study-shows-5-year-survival-of-diabetes-and-non-diabetes-patients-post-kidney-transplant/.

The authors declare that there are no conflicts of interest present.