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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nid</journal-id><journal-title-group><journal-title xml:lang="ru">Нефрология и диализ</journal-title><trans-title-group xml:lang="en"><trans-title>Nephrology and Dialysis</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1680-4422</issn><issn pub-type="epub">2618-9801</issn><publisher><publisher-name>Российское диализное общество</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">nid-451</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Внезапная смерть и интервал QTc у пациентов на гемодиализе</article-title><trans-title-group xml:lang="en"><trans-title>Sudden death and interval QTc in hemodialysis patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сабодаш</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Sabodash</surname><given-names>A. B.</given-names></name></name-alternatives><email xlink:type="simple">sabodash@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Салихова</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Salikhova</surname><given-names>K. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Земченков</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zemchenkov</surname><given-names>G. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макарова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Makarova</surname><given-names>O. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скатерникова</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Skaternikova</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Банишевская</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Banishevskaya</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Земченков</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Zemchenkov</surname><given-names>A. Y.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Санкт-Петербургский государственный медицинский университет им. И.П. Павлова; ББраун Авитум Руссланд Клиникс</institution><country>Россия</country></aff><aff xml:lang="en"><institution>BBraun Avitum Russland Clinics; First Saint-Petersburg I.P. Pavlov State medical university</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ББраун Авитум Руссланд Клиникс</institution><country>Россия</country></aff><aff xml:lang="en"><institution>BBraun Avitum Russland Clinics</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Первый Санкт-Петербургский государственный медицинский университет им. И.П. Павлова; Северо-Западный государственный медицинский университет им. И.И. Мечникова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Saint-Petersburg I.P. Pavlov State medical university; North-Western I.I.Mechnikov State medical university</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>19</day><month>08</month><year>2024</year></pub-date><volume>18</volume><issue>4</issue><fpage>394</fpage><lpage>403</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сабодаш А.Б., Салихова К.А., Земченков Г.А., Макарова О.В., Скатерникова В.В., Банишевская А.В., Земченков А.Ю., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Сабодаш А.Б., Салихова К.А., Земченков Г.А., Макарова О.В., Скатерникова В.В., Банишевская А.В., Земченков А.Ю.</copyright-holder><copyright-holder xml:lang="en">Sabodash A.B., Salikhova K.A., Zemchenkov G.A., Makarova O.V., Skaternikova V.V., Banishevskaya A.V., Zemchenkov A.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nephro.ru/jour/article/view/451">https://journal.nephro.ru/jour/article/view/451</self-uri><abstract><p>Цель: оценить долю внезапной смерти среди диализной популяции, выраженность удлинения QTc как фактора риска фатальных аритмий, факторы, связанные с удлинением, и динамику интервала в ходе сеанса и на протяжении исследования. Пациенты и методы: оценена доля внезапной смерти для 1229 летальных исходов (45%). У 159 пациентов одного центра в проспективном наблюдении трижды с промежутком в 5 месяцев оценен скорректированный на частоту ритма интервал QTc. Результаты: Почти половина случаев смерти гемодиализных пациентов в Санкт-Петербурге происходят внезапно в сроки 31 (10÷65) месяцев от начала диализа в сравнении со сроками диализа умерших не внезапно 36 (21÷68) месяцев и продолжающих лечение 41 (13÷76) месяц. Случаи внезапной смерти равномерно распределены по неделе, не внезапной - смещены на длинный междиализный интервал (р=0,044). Доля пациентов с удлиненным интервалом QTc составила 17%. Длина QTc была выше при гиперфосфатемии (р=0,04); отклонение QTc ассоциировалось с бóльшей коморбидностью; большему ИММЛЖ (на 10 г/м2) соответствовало удлинение QTc на 6-7 мсек; длина QTc коррелировала с конечным диастолическим объемом левого желудочка (r=+0,264; р=0,002), c конечным систолическим объемом (r=+0,372; р&lt;0,001), c диаметром левого предсердия (r=+0,172; р=0,05). В ходе сеанса отмечено удлинение QTc (+6±35 мсек; р=0,059), которое было связано с ультрафильтрацией (r=0,23; р=0,01) и уровнем калия выше медианы 5,13 ммоль/л (+8±26; р&lt;0,05). При повторных измерениях группа со стабильным удлинением QTc имела более высокие уровни кальция и фосфатов (р&lt;0,05). Заключение: внезапная смерть распространена на диализе; измерение QTc способно дать оценку риска фатальных нарушений ритма. Бóльшая продолжительность, а также удлинение интервала QTc в ходе сеанса гемодиализа и на протяжении наблюдения связаны с предотвратимыми и модифицируемыми факторами (ГЛЖ, водно-электролитный баланс и параметры минеральных и костных нарушений при ХБП).</p></abstract><trans-abstract xml:lang="en"><p>The aim: to evaluate the percentage of sudden cardiac death (SCD) in dialysis population and its relation to the QTc duration as a fatal arrhythmia factor and the predictors for its duration at baseline, during dialysis session and during follow-up. Patients and method: SCD percentage was evaluated in 1229 cases of death. In prospective follow-up research, 159 patients in one dialysis center, the QTc duration was measured three times with 5 months interval. Results: in 45% cases of sudden death occurred in average after 31 (10÷65) months of dialysis compared with 36 (21÷68) months in non-SCD cases and 41 (13÷76) months among alive patients. The cases of SCD have uniform distribution during the week while non-SCD cases were shifted towards long interdialytic interval (p=0.044). QTc was prolonged in 17% of patients and was longer in hyperphosphatemia (p=0.04) and at higher comorbidity; the higher LVMI (by 10 g/m2) was linked with longer QTc (by 6-7 msec); QTc correlated with end-diastolic volume (r=+0.264; p=0.002), with end-systolic volume (r=+0.372; p&lt;0.001), with left atrium diameter (r=+0.172; p=0.05). A prolongation of QTc during the dialysis session (+6±35 msec; p=0.059) was associated with ultrafiltration (r=0.23; p=0.01) and potassium level higher than its median level of 5.13 mM (+8±26; p&lt;0.05). In follow-up period, the stable QTc duration correlated with higher calcemia and phosphatemia (p&lt;0.05). Conclusion: SCD is frequent in dialysis patients; QTc measurement enables one to assess the risk of fatal arrhythmia. The duration length and the prolongation of QTc in dialysis session and during follow-up are associated with preventable and modifiable factors (cardiac remodeling, fluid and ionic balance, mineral and bone disorders parameters).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гемодиализ</kwd><kwd>скорректированный интервал QT</kwd><kwd>гипергидратация</kwd><kwd>гиперфосфатемия</kwd><kwd>гиперкальциемия</kwd><kwd>гипертрофия левого желудочка</kwd><kwd>hemodialysis</kwd><kwd>corrected QT interval</kwd><kwd>volume overload</kwd><kwd>hyperphosphatemia</kwd><kwd>hypercalcemia</kwd><kwd>cardiac remodeling</kwd><kwd>left ventricular hypertrophy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Вишневский К.А., Беляев А.Е., Мироненко А.Н. Полиморбидность как предиктор летальности у пациентов, находящихся на постоянной заместительной почечной терапии гемодиализом. Нефрология. 2015. 19(4):89-94.</mixed-citation><mixed-citation xml:lang="en">Вишневский К.А., Беляев А.Е., Мироненко А.Н. Полиморбидность как предиктор летальности у пациентов, находящихся на постоянной заместительной почечной терапии гемодиализом. Нефрология. 2015. 19(4):89-94.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Зелтынь-Абрамов Е.М., Потешкина Н.Г., Андрусев А.М. и соавт. Гемодиализ и сердце: вопросов больше, чем ответов. Нефрология и диализ. 2016. 18(1):69-75.</mixed-citation><mixed-citation xml:lang="en">Зелтынь-Абрамов Е.М., Потешкина Н.Г., Андрусев А.М. и соавт. Гемодиализ и сердце: вопросов больше, чем ответов. Нефрология и диализ. 2016. 18(1):69-75.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Карпунин С.А., Бородулина Е.О., Шутов А.М. и соавт. Ремоделирование сердца и легочная гипертензия у больных, получающих лечение гемодиализом. Нефрология и диализ. 2016. 18(1):62-68.</mixed-citation><mixed-citation xml:lang="en">Карпунин С.А., Бородулина Е.О., Шутов А.М. и соавт. Ремоделирование сердца и легочная гипертензия у больных, получающих лечение гемодиализом. Нефрология и диализ. 2016. 18(1):62-68.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Alabd M.A., El-Hammady W., Shawky A. et al. QT Interval and QT Dispersion in Patients Undergoing Hemodialysis: Revisiting the Old Theory. Nephron Extra. 2011. 1(1):1-8.</mixed-citation><mixed-citation xml:lang="en">Alabd M.A., El-Hammady W., Shawky A. et al. QT Interval and QT Dispersion in Patients Undergoing Hemodialysis: Revisiting the Old Theory. Nephron Extra. 2011. 1(1):1-8.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Arramreddy R., Sun S.J., Munoz Mendoza J. et al. Individualized reduction in dialysate sodium in conventional in-center hemodialysis. Hemodial Int. 2012. 16(4): 473-80.</mixed-citation><mixed-citation xml:lang="en">Arramreddy R., Sun S.J., Munoz Mendoza J. et al. Individualized reduction in dialysate sodium in conventional in-center hemodialysis. Hemodial Int. 2012. 16(4): 473-80.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Bavbek N., Yilmaz H., Erdemli H.K. et al. Correlation between iron stores and QTc dispersion in chronic ambulatory peritoneal dialysis patients. Ren Fail. 2014. 36(2): 187-90.</mixed-citation><mixed-citation xml:lang="en">Bavbek N., Yilmaz H., Erdemli H.K. et al. Correlation between iron stores and QTc dispersion in chronic ambulatory peritoneal dialysis patients. Ren Fail. 2014. 36(2): 187-90.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bazett H.C. An analysis of the time-relations of electrocardiograms. Heart. 1920.7:353-370.</mixed-citation><mixed-citation xml:lang="en">Bazett H.C. An analysis of the time-relations of electrocardiograms. Heart. 1920.7:353-370.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Borrego-Utiel F.J., Pérez-del Barrio Mdel P., Biechy-Baldan Mdel M., Segura-Torres P. Cinacalcet may prolong the QT interval in patients on haemodialysis with secondary hyperparathyroidism. Nefrologia. 2013.33(2):272-3.</mixed-citation><mixed-citation xml:lang="en">Borrego-Utiel F.J., Pérez-del Barrio Mdel P., Biechy-Baldan Mdel M., Segura-Torres P. Cinacalcet may prolong the QT interval in patients on haemodialysis with secondary hyperparathyroidism. Nefrologia. 2013.33(2):272-3.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Chertow G.M., Block G.A., Correa-Rotter R. et al. Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis. N Engl J Med. 2012. 367(26): 2482-94.</mixed-citation><mixed-citation xml:lang="en">Chertow G.M., Block G.A., Correa-Rotter R. et al. Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis. N Engl J Med. 2012. 367(26): 2482-94.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Claes K.J., Heye S., Nuyens D. et al. Impact of vascular calcification on corrected QT interval at the time of renal transplantation. Am J Nephrol. 2012. 35(1):24-30.</mixed-citation><mixed-citation xml:lang="en">Claes K.J., Heye S., Nuyens D. et al. Impact of vascular calcification on corrected QT interval at the time of renal transplantation. Am J Nephrol. 2012. 35(1):24-30.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Di Iorio B., Bellasi A., Russo B. Mortality in kidney disease patients treated with phosphate binders: a randomized study. Clin J Am Soc Nephrol. 2012. 7(3):487-93.</mixed-citation><mixed-citation xml:lang="en">Di Iorio B., Bellasi A., Russo B. Mortality in kidney disease patients treated with phosphate binders: a randomized study. Clin J Am Soc Nephrol. 2012. 7(3):487-93.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Di Iorio B., Bellasi A. QT interval in CKD and HD patients. Clin Kidney J. 2013. 6(2):137-43.</mixed-citation><mixed-citation xml:lang="en">Di Iorio B., Bellasi A. QT interval in CKD and HD patients. Clin Kidney J. 2013. 6(2):137-43.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Di Iorio B., Torraca S., Piscopo C. et al. Dialysate bath and QTc interval in patients on chronic maintenance hemodialysis: pilot study of single dialysis effects. J Nephrol. 2012. 25(5):653-60.</mixed-citation><mixed-citation xml:lang="en">Di Iorio B., Torraca S., Piscopo C. et al. Dialysate bath and QTc interval in patients on chronic maintenance hemodialysis: pilot study of single dialysis effects. J Nephrol. 2012. 25(5):653-60.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Di Lullo L., Rivera R., Barbera V. et al. Sudden cardiac death and chronic kidney disease: From pathophysiology to treatment strategies. Int J Cardiol. 2016. 217:16-27.</mixed-citation><mixed-citation xml:lang="en">Di Lullo L., Rivera R., Barbera V. et al. Sudden cardiac death and chronic kidney disease: From pathophysiology to treatment strategies. Int J Cardiol. 2016. 217:16-27.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Flachskampf F. Non-invasive assessment of cardiac structure and function - what nephrologists must know. 53th ERA-EDTA. Uremic cardiomyopathy. May, 22 2016, http://eraedta.conference2web.com/webcast/2016/2097, accessed 12.08.2016</mixed-citation><mixed-citation xml:lang="en">Flachskampf F. Non-invasive assessment of cardiac structure and function - what nephrologists must know. 53th ERA-EDTA. Uremic cardiomyopathy. May, 22 2016, http://eraedta.conference2web.com/webcast/2016/2097, accessed 12.08.2016</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Flueckiger P., Pastan S., Goyal A. et al. Associations of ECG interval prolongations with mortality among ESRD patients evaluated for renal transplantation. Ann Transplant. 2014. 19:257-68.</mixed-citation><mixed-citation xml:lang="en">Flueckiger P., Pastan S., Goyal A. et al. Associations of ECG interval prolongations with mortality among ESRD patients evaluated for renal transplantation. Ann Transplant. 2014. 19:257-68.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hage F.G., de Mattos A.M., Khamash H. et al. QT prolongation is an independent predictor of mortality in end-stage renal disease. Clin Cardiol 2010. 33: 361-366.</mixed-citation><mixed-citation xml:lang="en">Hage F.G., de Mattos A.M., Khamash H. et al. QT prolongation is an independent predictor of mortality in end-stage renal disease. Clin Cardiol 2010. 33: 361-366.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Huang C.W., Lee M.J., Lee P.T. et al. Low Potassium Dialysate as a Protective Factor of Sudden Cardiac Death in Hemodialysis Patients with Hyperkalemia. PLoS One. 2015. 10(10):e0139886.</mixed-citation><mixed-citation xml:lang="en">Huang C.W., Lee M.J., Lee P.T. et al. Low Potassium Dialysate as a Protective Factor of Sudden Cardiac Death in Hemodialysis Patients with Hyperkalemia. PLoS One. 2015. 10(10):e0139886.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ishii J., Takahashi H., Kitagawa F. et al. Multimarker approach to risk stratification for long-term mortality in patients on chronic hemodialysis. Circ J. 2015. 79(3):656-63.</mixed-citation><mixed-citation xml:lang="en">Ishii J., Takahashi H., Kitagawa F. et al. Multimarker approach to risk stratification for long-term mortality in patients on chronic hemodialysis. Circ J. 2015. 79(3):656-63.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Jadoul M., Thumma J., Fuller D.S. et al. Modifiable practices associated with sudden death among hemodialysis patients in the DOPPS. Clin J Am Soc Nephrol. 2012. 7(5):765-74.</mixed-citation><mixed-citation xml:lang="en">Jadoul M., Thumma J., Fuller D.S. et al. Modifiable practices associated with sudden death among hemodialysis patients in the DOPPS. Clin J Am Soc Nephrol. 2012. 7(5):765-74.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">January C.T., Wann L.S., Alpert J.S. et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation. 2014. 130(23):e199-267.</mixed-citation><mixed-citation xml:lang="en">January C.T., Wann L.S., Alpert J.S. et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation. 2014. 130(23):e199-267.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Kestenbaum B., Rudser K.D., Shlipak M.G. et al. Kidney function, electrocardiographic findings, and cardiovascular events among older adults. Clin J Am Soc Nephrol. 2007. 2: 501-508.</mixed-citation><mixed-citation xml:lang="en">Kestenbaum B., Rudser K.D., Shlipak M.G. et al. Kidney function, electrocardiographic findings, and cardiovascular events among older adults. Clin J Am Soc Nephrol. 2007. 2: 501-508.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Khosoosi Niaki M.R., Saravi M., Oliaee F. et al. Changes in QT interval before and after hemodialysis. Caspian J Intern Med. 2013. 4(1):590-4.</mixed-citation><mixed-citation xml:lang="en">Khosoosi Niaki M.R., Saravi M., Oliaee F. et al. Changes in QT interval before and after hemodialysis. Caspian J Intern Med. 2013. 4(1):590-4.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kim H.W., Park C.W., Shin Y.S. Calcitriol regresses cardiac hypertrophy and QT dispersion in secondary hyperparathyroidism on hemodialysis. Nephron Clin Pract. 2006. 102(1):c21-9.</mixed-citation><mixed-citation xml:lang="en">Kim H.W., Park C.W., Shin Y.S. Calcitriol regresses cardiac hypertrophy and QT dispersion in secondary hyperparathyroidism on hemodialysis. Nephron Clin Pract. 2006. 102(1):c21-9.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kinoshita T., Asai T., Suzuki T. et al. Time course and prognostic implications of QT interval in patients with coronary artery disease undergoing coronary bypass surgery. J Cardiovasc Electrophysiol. 2012. 23(6):645-9.</mixed-citation><mixed-citation xml:lang="en">Kinoshita T., Asai T., Suzuki T. et al. Time course and prognostic implications of QT interval in patients with coronary artery disease undergoing coronary bypass surgery. J Cardiovasc Electrophysiol. 2012. 23(6):645-9.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Lafrance J.P., Rahme E., Iqbal S., et al. Magnitude of discordance between registry data and death certificate when evaluating leading causes of death in dialysis patients. BMC Med Res Methodol. 2013. 13:51.</mixed-citation><mixed-citation xml:lang="en">Lafrance J.P., Rahme E., Iqbal S., et al. Magnitude of discordance between registry data and death certificate when evaluating leading causes of death in dialysis patients. BMC Med Res Methodol. 2013. 13:51.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">McDonald S., Excell L., Livingston B. 33rd Annual Report- 2010 Report. ANZDATA 2010. www.anzdata.org.au/anzdata/AnzdataReport/33rdReport/ANZDATA33rdReport.pdf, accessed 28.07.2016</mixed-citation><mixed-citation xml:lang="en">McDonald S., Excell L., Livingston B. 33rd Annual Report- 2010 Report. ANZDATA 2010. www.anzdata.org.au/anzdata/AnzdataReport/33rdReport/ANZDATA33rdReport.pdf, accessed 28.07.2016</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Nie Y., Zou J., Liang Y. et al. Electrocardiographic Abnormalities and QTc Interval in Patients Undergoing Hemodialysis. PLoS One. 2016. 11(5): e0155445.</mixed-citation><mixed-citation xml:lang="en">Nie Y., Zou J., Liang Y. et al. Electrocardiographic Abnormalities and QTc Interval in Patients Undergoing Hemodialysis. PLoS One. 2016. 11(5): e0155445.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Pun P.H., Abdalla S., Block G.A. et al. Cinacalcet, dialysate calcium concentration, and cardiovascular events in the EVOLVE trial. Hemodial Int. 2016. 20(3):421-31.</mixed-citation><mixed-citation xml:lang="en">Pun P.H., Abdalla S., Block G.A. et al. Cinacalcet, dialysate calcium concentration, and cardiovascular events in the EVOLVE trial. Hemodial Int. 2016. 20(3):421-31.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Pun P.H., Horton J.R., Middleton J.P. Dialysate calcium concentration and the risk of sudden cardiac arrest in hemodialysis patients. Clin J Am Soc Nephrol. 2013. 8(5):797-803.</mixed-citation><mixed-citation xml:lang="en">Pun P.H., Horton J.R., Middleton J.P. Dialysate calcium concentration and the risk of sudden cardiac arrest in hemodialysis patients. Clin J Am Soc Nephrol. 2013. 8(5):797-803.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Ramesh S., Zalucky A., Hemmelgarn B.R. Incidence of sudden cardiac death in adults with end-stage renal disease: a systematic review and meta-analysis. BMC Nephrol. 2016. 17(1):78.</mixed-citation><mixed-citation xml:lang="en">Ramesh S., Zalucky A., Hemmelgarn B.R. Incidence of sudden cardiac death in adults with end-stage renal disease: a systematic review and meta-analysis. BMC Nephrol. 2016. 17(1):78.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Roberts M.A., Polkinghorne K.R., McDonald S.P., Ierino F.L. Secular trends in cardiovascular mortality rates of patients receiving dialysis compared with the general population. Am J Kidney Dis. 2011. 58(1):64-72.</mixed-citation><mixed-citation xml:lang="en">Roberts M.A., Polkinghorne K.R., McDonald S.P., Ierino F.L. Secular trends in cardiovascular mortality rates of patients receiving dialysis compared with the general population. Am J Kidney Dis. 2011. 58(1):64-72.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Sagie A., Larson M.G., Goldberg R.J. et al. An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study). Am J Cardiol. 1992. 70:797-801.</mixed-citation><mixed-citation xml:lang="en">Sagie A., Larson M.G., Goldberg R.J. et al. An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study). Am J Cardiol. 1992. 70:797-801.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Salvi V., Karnad D.R., Kerkar V. et al. Comparison of two methods of estimating reader variability in QT interval measurements in thorough QT/QTc studies. Ann Noninvasive Electrocardiol. 2014. 19(2):182-9.</mixed-citation><mixed-citation xml:lang="en">Salvi V., Karnad D.R., Kerkar V. et al. Comparison of two methods of estimating reader variability in QT interval measurements in thorough QT/QTc studies. Ann Noninvasive Electrocardiol. 2014. 19(2):182-9.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Temiz G., Yalçın A.U., Mutluay R. et al. Effects of cinacalcet treatment on QT interval in hemodialysis patients. Anatol J Cardiol. 20155.</mixed-citation><mixed-citation xml:lang="en">Temiz G., Yalçın A.U., Mutluay R. et al. Effects of cinacalcet treatment on QT interval in hemodialysis patients. Anatol J Cardiol. 20155.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Vandenberk B., Vandael E., Robyns T. et al. Which QT Correction Formulae to Use for QT Monitoring? J Am Heart Assoc. 2016. 5(6). pii: e003264.</mixed-citation><mixed-citation xml:lang="en">Vandenberk B., Vandael E., Robyns T. et al. Which QT Correction Formulae to Use for QT Monitoring? J Am Heart Assoc. 2016. 5(6). pii: e003264.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Wheeler D.C., London G.M., Parfrey P.S. et al. Effects of cinacalcet on atherosclerotic and nonatherosclerotic cardiovascular events in patients receiving HD: EVOLVE trial. J Am Heart Assoc. 2014. 3(6): e001363.</mixed-citation><mixed-citation xml:lang="en">Wheeler D.C., London G.M., Parfrey P.S. et al. Effects of cinacalcet on atherosclerotic and nonatherosclerotic cardiovascular events in patients receiving HD: EVOLVE trial. J Am Heart Assoc. 2014. 3(6): e001363.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
