nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-493Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESФакторы риска развития впервые возникшего сахарного диабета после трансплантации почки у детейRisk factors for new-onset diabetes after transplantation in childrenГалкинаА. О.GalkinaA. O.Ed3565@yandex.ruПетросянЭ. К.PetrosyanE. K.noemail@neicon.ruРумянцевА. Л.RumyantsevA. L.noemail@neicon.ruМолчановаЕ. А.MolchanovaE. A.noemail@neicon.ruМолчановаМ. С.MolchanovaM. S.noemail@neicon.ruВаловА. Л.ValovA. L.noemail@neicon.ruШумиловП. В.ShumilovP. V.noemail@neicon.ruГБОУ ВПО Российский национальный исследовательский медицинский университет им. Н.И. ПироговаРоссияPirogov Russian National Research Medical UniversityRussian FederationФГБУ Российская детская клиническая больницаРоссияRussian Children’s Clinical HospitalRussian Federation201529082024173265272Copyright © Галкина А.О., Петросян Э.К., Румянцев А.Л., Молчанова Е.А., Молчанова М.С., Валов А.Л., Шумилов П.В., 20242024Галкина А.О., Петросян Э.К., Румянцев А.Л., Молчанова Е.А., Молчанова М.С., Валов А.Л., Шумилов П.В.Galkina A.O., Petrosyan E.K., Rumyantsev A.L., Molchanova E.A., Molchanova M.S., Valov A.L., Shumilov P.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/493

Сахарный диабет после трансплантации органов (СДПТ) - известное осложнение иммуносупрессивной терапии, являющееся фактором, влияющим на выживаемость аллотрансплантата, хорошо исследованное во взрослой популяции, но меньше в педиатрической. Цель исследования. Определить частоту встречаемости СДПТ и факторы, влияющие на его развитие у детей после аллотрансплантации трупной почки, а также влияние сахарного диабета после трансплантации на выживаемость аллотрансплантата. Материалы и методы. За период с 2008 по 2013 гг. нами проанализированы данные генеалогического анамнеза, лабораторных показателей: уровень глюкозы, холестерина, триглицеридов, мочевины, креатинина, наличие и степень активности ЦМВ, определенную ПЦР-методом до и после трансплантации, а также массо-ростовые показатели с определением ИМТ у 164 детей с аллотрансплантатом почки. Результаты. Частота развития СД у детей с аллотрансплантатом почки составила 9,76%. Среди факторов риска СДПТ нами достоверно выявлены наследственная предрасположенность к сахарному диабету (СД), метаболическому синдрому (МС) (р=0,042 и р=0,048, соответственно), более высокий ИМТ (р=0,009). Более того, продемонстрировано, что возникший после трансплантации почки СД у детей снижает выживаемость аллотрансплантата (p=0,01).

New-onset diabetes after transplantation (NODAT) is a well-known complication of immunosuppressive therapy after transplantation, being a risk factor of allograft survival. NADAT is well-studied in the adult population, but significantly less studied in the pediatric one. Aim. To determine the frequency and factors influencing the development of NODAT in children and its impact on the survival rate of the allograft. Materials and Methods. During 5 year period (2008-2013) we analyzed genealogical data, blood glucose, cholesterol, triglycerides, urea, creatinine, CMV infection using specific PCR before and after transplantation, as well as mass-growth parameters, BMI calculation in 164 children with kidney allograft. Results. The incidence of diabetes in children with kidney allograft was 9.76%. Among the risk factors NODAT we identified a genetic predisposition to diabetes, metabolic syndrome (р=0.042 и р=0.048), high BMI (р=0.009). We also demonstrated that diabetes in children developed after kidney transplantation reduces allograft survival.

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The authors declare that there are no conflicts of interest present.