nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-595Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESБиомаркеры острого почечного повреждения: клинические аспекты (Обзор литературы)Biomarkers of acute kidney injury: clinical aspects ReviewКолесниковС. В.KolesnikovS. V.igdrasil03@mail.ruБорисовА. С.BorisovA. S.noemail@neicon.ruФГБУ «ННИИПК им. акад. Е.Н. Мешалкина» Минздрава России, НовосибирскРоссияMeshalkin State Research Institute of Circulation Pathology, NovosibirskRussian Federation201320092024153184190Copyright © Колесников С.В., Борисов А.С., 20242024Колесников С.В., Борисов А.С.Kolesnikov S.V., Borisov A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/595

Острое почечное повреждение (ОПП) является распространенным, тяжелым, дорогостоящим в лечении и опасным для жизни состоянием, поражающим критически больных пациентов. В последние десятилетия внимание исследователей приковано к поиску биомаркеров ОПП, способных к раннему и адекватному мониторингу нарушенной функции почек, что необходимо для своевременного начала заместительной почечной терапии и улучшения прогноза. В литературном обзоре изложены результаты применения современных биомаркеров ОПП в клинической практике у различных категорий пациентов с ОПП. Авторами обобщены результаты доказательного использования биомаркеров ОПП на основе современных статистических методов оценки их информативности, представлены данные метаанализа, проанализированы проблемы клинической пригодности маркеров ОПП и перспективы их дальнейшего применения.

Acute kidney injury (AKI) is a common, serious, costly and deadly disease involving critically ill patients. Over the last decade, the attention of researchers and clinicians was focused on the search for biomarkers AKI which are potent for early and adequate monitoring of impaired kidney function, necessary for the timely initiation of renal replacement therapy and improve prognosis. In the review we present the results of the application of modern AKI biomarkers in clinical practice in various categories of patients with AK. The authors summarized the results of the use of evidence-based studies employing applying modern statistical methods (AUC-ROC) to assess their information content, meta-analysis to evaluate the clinical utility of the AKI markers and prospects for their further use.

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The authors declare that there are no conflicts of interest present.