nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-602Research ArticleНАБЛЮДЕНИЯ ИЗ ПРАКТИКИCASE REPORTSРецидивирующий атипичный гемолитико-уремический синдром, манифестировавший поражением поджелудочной железыRecurrent atypical hemolytic uremic syndrome, manifested in severe pancreas lesionКучиеваА. М.KuchievaA. M.nefrologia_2013@mail.ruКозловскаяН. Л.KozlovskayaN. L.noemail@neicon.ruДемьяноваК. А.DemyanovaK. A.noemail@neicon.ruДобросмысловИ. А.DobrosmyslovI. A.noemail@neicon.ruГБОУ ВПО «Первый МГМУ им. И.М. Сеченова» Минздрава РоссииРоссияSechenov First Moscow State Medical UniversityRussian Federation201320092024153236239Copyright © Кучиева А.М., Козловская Н.Л., Демьянова К.А., Добросмыслов И.А., 20242024Кучиева А.М., Козловская Н.Л., Демьянова К.А., Добросмыслов И.А.Kuchieva A.M., Kozlovskaya N.L., Demyanova K.A., Dobrosmyslov I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/602

Представлено клиническое наблюдение рецидивирующего атипичного гемолитико-уремического синдрома, первым проявлением которого было развитие острого панкреатита. Обсуждаются возможные взаимосвязи между поражением поджелудочной железы и развитием острой тромботической микроангиопатии.

We report a case of recurrent atypical hemolytic uremic syndrome presented in pancreas injury. The possible interactions between the thrombotic microangiopathy and occurrence of acute pancreatitis are discussed.

atypical hemolytic uremic syndromethrombotic microangiopathyacute pancreatitisanticoagulant therapyатипичный гемолитико-уремический синдромтромботическая микроангиопатияострый панкреатитантикоагулянтная терапияReferencesAfshar-Kharghan V. Unleashed platelets in aHUS // Blood. 2008. Vol. 111. P. 5266.Afshar-Kharghan V. Unleashed platelets in aHUS // Blood. 2008. Vol. 111. P. 5266.Amara U., Flierl M.A., Rittirsch D. et al. Molecular intercommunication between the Complement and Coagulation systems // The J. of Immunology. 2010. Vol. 185. P. 5628–5636.Amara U., Flierl M.A., Rittirsch D. et al. Molecular intercommunication between the Complement and Coagulation systems // The J. of Immunology. 2010. Vol. 185. P. 5628–5636.Besbas N., Karpman D., Landau D. et al. A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, and related disorders // Kidney Int. 2006. Vol. 70. P. 423–431.Besbas N., Karpman D., Landau D. et al. A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, and related disorders // Kidney Int. 2006. Vol. 70. P. 423–431.Caprioli J., Noris M., Brioschi S. et al. Genetics of HUS: the impact of MCP, CFH and IF mutations on clinical presentation, response to treatment, and outcome // Blood. 2006. Vol. 108. P. 1267–1279.Caprioli J., Noris M., Brioschi S. et al. Genetics of HUS: the impact of MCP, CFH and IF mutations on clinical presentation, response to treatment, and outcome // Blood. 2006. Vol. 108. P. 1267–1279.Chandler W.L., Jelacic S., Boster D.R. et al. Prothrombotic coagulation abnormalities preceeding the hemolytic-uremic syndrome // N. Engl. J. Med. 2002. Vol. 346. P. 23–32.Chandler W.L., Jelacic S., Boster D.R. et al. Prothrombotic coagulation abnormalities preceeding the hemolytic-uremic syndrome // N. Engl. J. Med. 2002. Vol. 346. P. 23–32.Fakhouri F., Fremeaux-Bacchi V. Does hemolytic uremic syndrome differ from thrombotic thrombocytopenic purpura? // Nat. Clin. Pract. Nephrol. 2007. Vol. 3. P. 679–687.Fakhouri F., Fremeaux-Bacchi V. Does hemolytic uremic syndrome differ from thrombotic thrombocytopenic purpura? // Nat. Clin. Pract. Nephrol. 2007. Vol. 3. P. 679–687.Grabowski E.F. The hemolytic-uremic syndrome – toxin, thrombin and thrombosis // N. Engl. J. Med. 2002. Vol. 346. P. 58–61.Grabowski E.F. The hemolytic-uremic syndrome – toxin, thrombin and thrombosis // N. Engl. J. Med. 2002. Vol. 346. P. 58–61.Hosler G.A., Cusumano A.M., Hutchins G.M. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are distinct pathologic entities. A review of 56 autopsy cases // Arch. Pathol. Lab. Med. 2003. Vol. 127. P. 834–839.Hosler G.A., Cusumano A.M., Hutchins G.M. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are distinct pathologic entities. A review of 56 autopsy cases // Arch. Pathol. Lab. Med. 2003. Vol. 127. P. 834–839.Huber-Lang M., Sarma F.S., Zetoune D. et al. Generation of C5a in the absence of C3: a new complement activation pathway // Nat. Med. 2006. Vol. 12. P. 682–687.Huber-Lang M., Sarma F.S., Zetoune D. et al. Generation of C5a in the absence of C3: a new complement activation pathway // Nat. Med. 2006. Vol. 12. P. 682–687.Kitchens C.S., Erkan D., Branda~o L.R. et al. Thrombotic storm revisited: preliminary diagnostic criteria suggested by the Thrombotic storm study group // Am. J. Med. 2011. Vol. 12. P. 290–296.Kitchens C.S., Erkan D., Branda~o L.R. et al. Thrombotic storm revisited: preliminary diagnostic criteria suggested by the Thrombotic storm study group // Am. J. Med. 2011. Vol. 12. P. 290–296.Kitchens C.S. Thrombotic storm: when thrombosis begets thrombosis // Am. J. Med. 1998. Vol. 104. P. 381–385.Kitchens C.S. Thrombotic storm: when thrombosis begets thrombosis // Am. J. Med. 1998. Vol. 104. P. 381–385.Licht C., Pluthero F.G., Li L. et al. Platelet-associated complement factor H in healthy persons and patients with atypical HUS // Blood. 2009. Vol. 114. P. 4538–4545.Licht C., Pluthero F.G., Li L. et al. Platelet-associated complement factor H in healthy persons and patients with atypical HUS // Blood. 2009. Vol. 114. P. 4538–4545.Loirat C., Noris M., Fremeaux-Bacchi V. Complement and the atypical hemolytic uremic syndrome in children // Pediatr. Nephrol. 2008. Vol. 23. P. 1957–1972.Loirat C., Noris M., Fremeaux-Bacchi V. Complement and the atypical hemolytic uremic syndrome in children // Pediatr. Nephrol. 2008. Vol. 23. P. 1957–1972.Mutch N.R., Robbie L.A., Booth N.A. Human thrombi contain an abundance of active thrombin // Thromb. Haemost. 2001. Vol. 86. P. 1028–1034.Mutch N.R., Robbie L.A., Booth N.A. Human thrombi contain an abundance of active thrombin // Thromb. Haemost. 2001. Vol. 86. P. 1028–1034.Noris M., Caprioli J., Bresin E. et al. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype // Clin. J. Am. Soc. Nephrol. 2010. Vol. 5. P. 1844–1859.Noris M., Caprioli J., Bresin E. et al. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype // Clin. J. Am. Soc. Nephrol. 2010. Vol. 5. P. 1844–1859.Noris M., Remuzzi G. Atypical hemolytic-uremic syndrome // N. Engl. J. Med. 2009. Vol. 361. P. 1676–1687.Noris M., Remuzzi G. Atypical hemolytic-uremic syndrome // N. Engl. J. Med. 2009. Vol. 361. P. 1676–1687.Stahl A.L., Vaziri-Sani F., Heinen S. et al. Factor H dysfunction in patients with hemolytic uremic syndrome contributes to complement deposition on platelets and their activation // Blood. 2008. Vol. 111. P. 5307–5315.Stahl A.L., Vaziri-Sani F., Heinen S. et al. Factor H dysfunction in patients with hemolytic uremic syndrome contributes to complement deposition on platelets and their activation // Blood. 2008. Vol. 111. P. 5307–5315.Swisher K.K., Doan J.T., Vesely S.K. et al. Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports // Haematologica. 2007. Vol. 92. P. 936–943.Swisher K.K., Doan J.T., Vesely S.K. et al. Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports // Haematologica. 2007. Vol. 92. P. 936–943.Van Geet C., Proesmans W., Arnout J. et al. Activation of both coagulation and fibrinolysis in childhood hemolytic uremic syndrome // Kidney. Int. 1998. Vol. 54. P. 1324–1330.Van Geet C., Proesmans W., Arnout J. et al. Activation of both coagulation and fibrinolysis in childhood hemolytic uremic syndrome // Kidney. Int. 1998. Vol. 54. P. 1324–1330.

The authors declare that there are no conflicts of interest present.