nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-979Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESХроническая болезнь почек у больных с хронической сердечной недостаточностью (Обзор литературы)Chronic kidney disease in chronic heart failure patients ReviewРезникЕ. В.ReznikE. V.elenaresnik@gmail.com. RGMUGT2@mail.ruГендлинГ. Е.GendlinG. E.noemail@neicon.ruГущинаВ. М.GuschinaV. M.noemail@neicon.ruСторожаковГ. И.StorojhakovG. I.noemail@neicon.ruКафедра госпитальной терапии № 2 ГОУ ВПО РГМУ Росздрава, ГКБ № 12, г. МоскваRussian Federation2010170620251211324Copyright © Резник Е.В., Гендлин Г.Е., Гущина В.М., Сторожаков Г.И., 20252025Резник Е.В., Гендлин Г.Е., Гущина В.М., Сторожаков Г.И.Reznik E.V., Gendlin G.E., Guschina V.M., Storojhakov G.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/979

У больных с хронической сердечной недостаточностью (ХСН) часто развивается хроническая болезнь почек (ХБП), что оказывает неблагоприятное прогностическое влияние. Основными звеньями патогенеза ХБП при ХСН являются снижение сердечного выброса, активация нейрогуморальных систем, воспаление и оксидативный стресс. Для замедления прогрессирования ХБП пациентам с ХСН необходимы строгий контроль АД и гликемии, назначение ингибиторов ангиотензин-превращающего фермента или антагонистов рецепторов ангиотензина II. Изучается нефропротективное и прогностическое значение блокаторов А1-рецепторов аденозина, антагонистов рецепторов V2 вазопрессина, блокаторов рецепторов к эндотелину, препаратов эритропоэтина.

Chronic kidney diseases are often and associated with bad prognosis in chronic heart failure patients. Decreasing of cardiac output, neurohumoral activation, inflammation and oxidative stress take part in pathophysiology of CKD in CHF. Blood pressure and glycemia control, angiotensin-II converting enzyme inhibitors and angiotensin II receptor blockers may improve outcomes in these patients. Nephroprotective and prognostic value of adenosine 1 and endotelin receptor blockers, antagonists of V2 vasopressin receptors, erythropoietin needs in further evaluation.

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The authors declare that there are no conflicts of interest present.