References

nid

Нефрология и диализ

Nephrology and Dialysis

1680-44222618-9801

Российское диализное общество

nid-982

Research Article

ОРИГИНАЛЬНЫЕ СТАТЬИ

ORIGINAL ARTICLES

Риск прогрессирования стероид-резистентного нефротического синдрома у детей ассоциирован с малой массой тела при рождении

Risk of progression of steroid-resistant nephrotic syndrome in children is associated with low birth weight

Приходина

Л. С.

Prikhodina

L. S.

prikhodina@rambler.ru

Длин

В. В.

Dlin

V. V.

noemail@neicon.ru

Игнатова

М. С.

Ignatova

M. S.

noemail@neicon.ru

ФГУ «МНИИ педиатрии и детской хирургии Росмедтехнологий», г. МоскваRussian Federation

2010

17062025

1213945

2025

Приходина Л.С., Длин В.В., Игнатова М.С.

Prikhodina L.S., Dlin V.V., Ignatova M.S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.nephro.ru/jour/article/view/982

В работе представлены результаты ретроспективного 10-летнего наблюдения за течением стероид-резистентного нефротического синдрома у 65 детей, у 5 из которых отмечалась малая масса тела при рождении (<2500 г), обусловленная недоношенностью. У пациентов с малой массой тела при рождении в отличие от детей, рожденных с нормальной массой тела, установлен высокий относительный риск (ОР) быстрого снижения функций почек (СКФ >10 мл/мин/1,73 м2/год), составляющий 2,53 (p < 0,05), и низкая пятилетняя почечная выживаемость (0 и 61%; р = 0,00084). Полученные результаты исследования свидетельствуют о влиянии малой массы тела при рождении на течение и прогноз стероид-резистентного нефротического синдрома у детей. Малая масса тела при рождении может рассматриваться в качестве фактора риска прогрессирования заболевания с быстрым снижением почечных функций.

The study presents the results of a retrospective one-center 10-years follow up study for outcome of idiopathic steroid-resistant nephrotic syndrome in 65 children including 5 patients who had low birth weight (<2500 g) due to prematurity. Low birth weight group had the high relative risk (RR) of low renal function (eGFR >10 ml/min, RR = 2,53; p < 0,05) and low 5-year cumulative renal survival (0 vs 61%; р = 0,00084) compared to normal birth weight patients. Low birth weight that reflects adverse effects on development in utero is a risk factor for progression of idiopathic SRNS in children that is often accompanied by a decline of renal function.

детистероид-резистентный нефротический синдроммалая масса тела при рождениипрогрессированиеchildrensteroid-resistant nephrotic syndromelow birth body weightprogression

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The authors declare that there are no conflicts of interest present.