nidНефрология и диализNephrology and Dialysis1680-44222618-9801Российское диализное обществоnid-996Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESНефротоксические эффекты высокоактивной антиретровирусной терапии (Обзор литературы)The nephrotoxic effects of highly active antiretroviral therapy: ReviewЮщукН. Д.YuchyukN. D.noemail@neicon.ruВолгинаГ. В.VolginaG. V.E-mail: VolginaGV@mail.ruТомилинаН. А.N.a. TomilinaI. .noemail@neicon.ruГаджикулиеваМ. М.GadzhikulievaM. M.noemail@neicon.ruКочарянК. А.KocharyanK. A.noemail@neicon.ruГОУ ВПО Московский государственный медико-стоматологический университет РосздраваРоссияGOU VPO Moscow State University of Medicine and Dentistry, Roszdrav of the Russian Federation, MoscowRussian FederationГОУ ВПО Московский государственный медико-стоматологический университет Росздрава; ФГУ НИИ трансплантологии и искусственных органов РосмедтехнологийРоссияGOU VPO Moscow State University of Medicine and Dentistry, Roszdrav of the Russian Federation, Moscow; V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowRussian Federation201017062025123154163Copyright © Ющук Н.Д., Волгина Г.В., Томилина Н.А., Гаджикулиева М.М., Кочарян К.А., 20252025Ющук Н.Д., Волгина Г.В., Томилина Н.А., Гаджикулиева М.М., Кочарян К.А.Yuchyuk N.D., Volgina G.V., N.a. Tomilina I..., Gadzhikulieva M.M., Kocharyan K.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephro.ru/jour/article/view/996

Высокоактивная антиретровирусная терапия (ВААРТ) значительно снизила летальность и риск прогрессии спид. Наряду с этими положительными эффеками, увеличился и риск повреждения почек. Различают следующие наиболее распространенные варианты последнего: острое повреждение почек, тубулоинтерстициальный нефрит, кристаллурия, нефролитиаз, синдром Фанкони и хроническая почечная недостаточность. Кроме того, ожидается, что улучшение выживаемости пациентов с ВИЧ, приведет к увеличению частоты развития хронических, связанных с ВААРТ метаболических осложнений, таких как диабет и дислипидемия, которые, в свою очередь, могут способствовать сосудистым заболеваниям почек и снижению функции почек. В обзоре описаны частота и механизмы неблагоприятных побочных почечных эффектов антиретровирусной терапии.

Highly active antiretroviral therapy (HAART) decreases considerably the mortality and the risk of AIDS progression. However HAART increases the risk of kidney damage. The most common variants of the damage are acute kidney injury, tubulointerstitial nephritis, crystalluria, nephrolithiasis, Fanconi syndrome and chronic renal failure. Furthermore, it is expected that improved survival of such patients is anticipated with increased risk of chronic HAART-associated metabolic complications such as diabetes and dyslipidemia, which, in turn, can contribute to vascular kidney diseases of and decreased renal function. This review describes the occurrence and the mechanisms of renal adverse effects of antiretroviral therapies.

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The authors declare that there are no conflicts of interest present.