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Том 8 №1 2006 год - Нефрология и диализ

Молекулярные механизмы интерстициального фиброза при прогрессирующих заболеваниях почек (Обзор литературы)

Чеботарева Н.В. Бобкова И.Н. Козловская Л.В.

Аннотация: Прогрессирование хронических заболеваний почек с нарастанием почечной недостаточности, требующей заместительной почечной терапии на терминальной стадии, является одной из основных проблем в теоретической и практической нефрологии. Всестороннее изучение иммуновоспалительных механизмов поражения почек, в частности большого спектра провоспалительных и профиброгенных молекулярных медиаторов тканевого повреждения, позволило более детально представить значение процессов клеточной пролиферации, накопления и расщепления экстрацеллюлярного матрикса (ЭЦМ) в развитии фиброзно-склеротических изменений почечной ткани, особенно быстром при несостоятельности механизмов самозащиты почки (ингибиторов цитокинов, антиоксидантов, белков теплового шока и др.).

Для цитирования: Чеботарева Н.В., Бобкова И.Н., Козловская Л.В. Молекулярные механизмы интерстициального фиброза при прогрессирующих заболеваниях почек (Обзор литературы). Нефрология и диализ. 2006. 8(1):26-35. doi:

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Ключевые слова: хронический гломерулонефрит, интерстициальный фиброз, мочевые показатели, моноцитарный хемотаксический протеин-1 (МСР-1), трансформирующий фактор роста - β1 (TGF-β1)

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