Clinical and morphological peculiarities and efficacy of treatment of children with focal segmental glomerulosclerosis in Kazakhstan
Abstract
In the last decades the frequency of the focal segmental glomerulosclerosis (FSGS) increases. It is established that the dependence of the response on therapy and prognosis of the FSGS depend on morphological type. The aim of our study was to assess the frequency of types of FSGS and the response on therapy in Kazakh children. We have observed 16 Kazakh children with FSGS that was manifested with the nephrotic syndrome (NS) in 11 children, nephritic syndrome (NiS) in 4 children and combination of the NS and NiS in 1 child. The most frequent morphological type of FSGS was tip-lesion - 7 (43,8%). Typical type was observed in 6 (37,5%) children and collapsing glomerulopathy in 1 (6,3%) child. In 2 children FSGS was probably associated with podocytes’ and collagen type IV gene mutations and was not assessed as a primary disease. 9 children with the NS have received cyclosporine A, methylprednisolone pulses and oral prednisolone. Complete remission was achieved in 8 children. All children with NiS have received ACEi and one of them received mofetil mycophenolate with methylprednisolone pulses. A decrease in proteinuria was found in some cases. Thus, the FSGS in Kazakh children more is more often manifested clinically with the nephrotic syndrome, more rarely with the nephritic syndrome, and morphologically - with tip-lesion and typical type. Cyclosporine in combination with pulses of methylprednisolone and oral prednisolone are effective in achievement of complete remission of the nephrotic syndrome, and mofetil myciphenolate with ACEi - in nephritic syndrome (partial remission).
About the Author
A. Ye. Naushabayeva
Научный центр педиатрии и детской хирургии МЗ РК; г. Алматы, Казахстан
Russian Federation
Russian Federation
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Review
For citations:
Naushabayeva A.Ye. Clinical and morphological peculiarities and efficacy of treatment of children with focal segmental glomerulosclerosis in Kazakhstan. Nephrology and Dialysis. 2009;11(2):103-108. (In Russ.)
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