Cardiorenal relationship in the early stages of chronic kidney disease
Abstract
There are structural and functional changes in myocardium of patients with chronic kidney disease (CKD) which cause high cardiovascular morbidity and mortality. The aim of this study was to reveal the correlations between the left ventricular hypertrophy (LVH), duration of hypertension, GFR and renal vascular resistance in patients on early stages of CKD. 102 patients (40 males, 62 females, mean age 44,2 ± 8,3 years) with CKD 1-3 stages (by NKF K/DOQI classification, 2002) were included in the study. The GFR was estimated by the serum creatinine level using the Cockcroft-Gault formula; left ventricular hypertrophy was determined according to echocardiography criteria. We also examined renal vascular resistance by Doppler ultrasonography in segmentar and intralobal arteries of kidneys. We diagnosed LVH and chronic heart failure in patients with higher renal vascular resistance 5 times more frequently and ischemic heart disease 4 times more frequently than in patients with normal renal resistance. There were a significant correlation between LVMI and RI and PI in intralobal arteries (r = 0,7, p < 0,01 and r = 0,57, p < 0,01 respectively) and negative correlation between LVMI and minimum diastolic velocity (MDV, r = -0,53, p < 0,05), LVMI and GFR (r = -0,34, P < 0,05).
About the Authors
Z. E. Grigoryan
МУЗ «Консультативно-диагностическая поликлиника»
Russian Federation
Russian Federation
M. E. Evsevieva
Кафедра внутренних болезней № 2 Ставропольской Государственной Медицинской Академии; г. Ставрополь
Russian Federation
Russian Federation
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For citations:
Grigoryan Z.E., Evsevieva M.E. Cardiorenal relationship in the early stages of chronic kidney disease. Nephrology and Dialysis. 2007;9(2):173-177. (In Russ.)
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