Preview

Nephrology and Dialysis

Advanced search

Vascular dysfunction in pathogenesis of osteopenia in children with chronic glomerulonephriritis

Abstract

In order to investigate the role of vascular dysfunction in pathogenesis of osteopenia in children with chronic glomerulonephriritis we examined 6 healthy children without osteopenia and 34 children with osteopenia: 9 patients with nephrotic syndrome and arterial hypertension, 9 patients with nephrotic syndrome without arterial hypertension, 11 patients with chronic interstitial kidney diseases (5 - with arterial hypertension, 6 - without it), 5 children without chronic diseases. In all of them the blood level of marker of bone formation osteocalcin , urinary levels of marker of bone resorbtion C-telopeptide and marker of vascular dysfunction molecule of cellular vascular adhesion-1 (VCAM-1) were measured by immunoenzyme assay. We found significant increase of a level VCAM-1 and significant decrease in level of markers of bone remodeling in children with chronic glomerulonephriritis, especially in those with nephrotic syndrome with arterial hypertension. We found that vascular dysfunction suppresses bone metabolism in children with chronic glomerulonephriritis, especially in those with arterial hypertension.

About the Authors

N. N. Kartamysheva
ГУ НЦЗД РАМН, г. Москва
Russian Federation


A. N. Sikatev
ГУ НЦЗД РАМН, г. Москва
Russian Federation


T. V. Sergeeva
ГУ НЦЗД РАМН, г. Москва
Russian Federation


A. G. Kucherenko
ГУ НЦЗД РАМН, г. Москва
Russian Federation


I. E. Smirnov
ГУ НЦЗД РАМН, г. Москва
Russian Federation


A. N. Tsygin
ГУ НЦЗД РАМН, г. Москва
Russian Federation


E. N. Tsygina
ГУ НЦЗД РАМН, г. Москва
Russian Federation


O. V. Chumakova
ГУ НЦЗД РАМН, г. Москва
Russian Federation


References

1. Джагер А., Стехоуер С.Д.А. Влияние ранних признаков высокого риска сердечно-сосудистых осложнений у больных при наличии и отсутствии сахарного диабета. Метаболизм миокарда 2000; 5: 3-9.

2. Лоренс Риггз Б., Джозеф Мелтон III Л. Остеопороз. Пер. с англ. М.:-СПб.: БИНОМ, Невский диалект 2000: 560 с.

3. Минченко Б.И., Марченкова Л.А. Биохимические маркеры метаболизма костной ткани. Лабораторная медицина 2000; 3: 45-59.

4. Моисеева Т.Ю. Особенности минерализации костной ткани растущего организма. Дисс. докт. мед. наук. М.: 2004.

5. Момбули Ж.В., Ванут П.М. Функция эндотелия после применения ингибиторов ангиотензинпревращающего фермента. Сердечно-сосудистое ремоделирование. 2000: 32-35.

6. Alagiakrishnan K., Juby A., Hanley D. et al. Role of vascular factors in osteoporosis. J Gerontol A Biol Sci Med Sci 2003; 58(4): 362-366.

7. Cappuccio F.P., Kalaitzidis R., Duneclift S., Eastwood J.B. Unravelling the links between calcium excretion, salt intake, hypertension, kidney stones and bone metabolism. J Nephrol 2000; 13(3): 169-177.

8. Jee W.S.S., Ke I.I.Z., Li X.J. Long-term anabolic effects of prostaglandin-E2 on tibial diaphyseal bone in male rats. Bone Miner 1991; 15: 33-55.

9. Yang R.-S., Liu T.-K., Lin-Shiau S.-Y. Increased bone growth by local prostaglandin E2 in rats. Calcif Tissue Int 1993; 52: 57-61.


Review

For citations:


Kartamysheva N.N., Sikatev A.N., Sergeeva T.V., Kucherenko A.G., Smirnov I.E., Tsygin A.N., Tsygina E.N., Chumakova O.V. Vascular dysfunction in pathogenesis of osteopenia in children with chronic glomerulonephriritis. Nephrology and Dialysis. 2006;8(2):170-175. (In Russ.)

Views: 7


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1680-4422 (Print)
ISSN 2618-9801 (Online)