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Influence of low protein diet on progression of chronic renal failure

Abstract

Еще в 1869 г. L. Beale [23] писал, что ограничение потребления белка облегчает состояние больных с нарушенной функцией почек, а F. Volhard [154] указывал, что у больных с хронической почечной недостаточностью (ХПН) «возможно отсрочить» повышение концентрации мочевины в крови на длительный период времени, уменьшая потребление азота до 3-5 г/сут (20-30 г/сут белка). В ряде случаев ему удавалось, ограничивая потребление белка, снизить высокий уровень мочевины в крови, что сопровождалось исчезновением симптомов уремии. L. Ambard, известный своими работами в области физиологии и патофизиологии почек, в 1909 г. предложил определять «дебит мочевины» - произведение концентрации мочевины на диурез в соотношении к уровню мочевины в крови. В норме константа Ambard равнялась 0,07, а ее увеличение характеризовало степень нарушения функции почек. Двумя годами позднее он отмечал, что больные с уремией часто выглядят истощенными и усугубляют свое состояние, если употребляют в пищу мясо [5].

About the Authors

V. M. Ermolenko
РМАПО, г. Москва
Russian Federation


T. A. Kozlova
РМАПО, г. Москва
Russian Federation


N. A. Michailova
РМАПО, г. Москва
Russian Federation


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Ermolenko V.M., Kozlova T.A., Michailova N.A. Influence of low protein diet on progression of chronic renal failure. Nephrology and Dialysis. 2006;8(4):310-320. (In Russ.)

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