Features of lectin-dependent thrombocyte’s aggregation in patients with mixed form of chronic glomerulonephritis

Abstract

32 patients with mixed form of chronic glomerulonephritis were examined during periods of high activity of nephritis and periods of remission achieved by active therapy. All patients were divided into 2 groups according to renal function: kidney function of 13 patients wasn’t compromised; 19 patients had I stage of CRF diagnosed. To reveal structure peculiarities of thrombocyte’s receptor thrombocyte aggregation inducted by various types of lectins at different stages of nephritis was determined. At periods of high activity of nephritis irrespective of kidney function, a significant reduction of speed, degree and time of thrombocyte aggregation was determined while adding Con A. This may testify low content of mannospecific carbohydrate residues. When patients without CRF were brought into remission, the increase in speed and degree of thrombocyte aggregation was revealed, which seemingly was caused by the restoration of quantity of mannospecific carbohydrate residues. Determination of speed and degree of thrombocyte aggregation inducted by Con A can serve as activity marker of chronic glomerulonephritis.