Bone remodeling as model of intercellular actions
Abstract
Bone remodeling is a complex regulated process consisting of intercellular action of two cell lines: osteoblasts providing bone formation and osteoclasts critical cells for bone resorption. Cytokines and growth factors particularly interleukin-1, members of TNF-superfamily and TNF-receptor superfamily play an important role in this process. Emerging date on the genesis of bone remodeling are redefining our understanding of the mechanisms of bone damage. New observations regarding maneuvers that downregulate such injurious bone responses may direct further studies that develop new diagnostic and therapeutic modalities.
About the Authors
N. N. Kartamysheva
НИИ педиатрии НЦЗД РАМН, г. Москва
Russian Federation
Russian Federation
O. V. Tchumakova
НИИ педиатрии НЦЗД РАМН, г. Москва
Russian Federation
Russian Federation
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Review
For citations:
Kartamysheva N.N., Tchumakova O.V. Bone remodeling as model of intercellular actions. Nephrology and Dialysis. 2004;6(1):43-46. (In Russ.)
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