Predictors of results of endovascular correction of renal artery stenosis

Relevance: endovascular correction of renal artery stenosis (ECRAS) is currently insufficiently implemented in clinical practice due to the lack of uniform indications and contraindications for intervention and patient management protocols. Today, prediction of the results of ECRAS are also not well understood. Objective: to identify significant predictors of outcomes of endovascular correction of hemodynamically significant renal artery stenosis using methods of univariate and multivariate analysis. Materials and methods: ECRAS results were analyzed in 167 patients (62.93±0.69 years old, from 25 to 82 years old, 44.9% men) who underwent 205 interventions. The observation time was 29.15±1.62 months. Using the methods of univariate (Kaplan-Meier) and multivariate analysis (Cox-regression), the effect of various prognostic factors on the survival of the renal artery (RA) was studied. RA survival was understood as maintaining its patency. The cessation of patency of the RA was observed in the event of hemodynamically significant restenosis or occlusion of the RA. Results and conclusions: patient survival rate after ECRAS was: 1-year-old - 99%, 3- and 5-year-old - 93%, and RA survival: 92%, 90%, and 79%, respectively. According to univariate analysis, significant (p<0.05) predictors of ECRAS results before the intervention were age (over 70 years), multifocal atherosclerosis, glomerular filtration rate (GFR) and stage of chronic kidney disease (CKD), a single functioning kidney; on the third day after the intervention - blood pressure (BP) control group; after 1 month - GFR; after 12 months - GFR, stage of CKD, control group and average blood pressure, number of antihypertensive drugs (AHD). According to multivariate analysis, the significant independent predictors of ECRAS results before the intervention were: the CKD stage and a single functioning kidney, and after 12 months - a single functioning kidney and the number of AHD.

предиктор, прогнозирование, скорость клубочковой фильтрации, хроническая болезнь почек, атеросклероз, стеноз почечной артерии, стентирование, артериальная гипертензия, predictor, forecasting, glomerular filtration rate, chronical kidney disease, atherosclerosis, renal artery stenosis, stenting, hypertension

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