Lipid abnormalities in patients on continuous ambulatory peritoneal dialysis
Abstract
During 2 years the effects of continuous ambulatory peritoneal dialysis (CAPD) on serum lipids and lipoproteins in 46 uremic patients were studied. The concentrations of very low density lipoproteins (VLDL) cholesterol (CHOL), LDL CHOL, serum CHOL and serum triglycerides (TG) increased significantly. High density lipoprotein CHOL have been reduced. We examined the effects of simvastatin, an HMG-CoA reductase inhibitor, and lipanor (ciprofibrat) on lipoprotein parameters in 20 uremic patients treated with CAPD. The patients with elevated cholesterol (n = 10) were administrated with 5 mg/day simvastatin for 6 months, the patients with elevated triglycerids obtained lipanor 50 mg/day. Significant decrease in serum total lipid, TG, and CHOL levels were observed when compared to pretreatment values. Our results confirm the adverse effect of CAPD on serum lipids. We conclude that simvastatin and ciprofibrat effective to the management of dyslipidemia in uremic patients treated with CAPD.
About the Authors
V. M. Ermolenko
Кафедра нефрологии и гемодиализа, кафедра биохимии Российской медицинской академии последипломного образования МЗ РФ; Московская городская больница им. С.П. Боткина
Russian Federation
Russian Federation
G. A. Yarovaya
Кафедра нефрологии и гемодиализа, кафедра биохимии Российской медицинской академии последипломного образования МЗ РФ; Московская городская больница им. С.П. Боткина
Russian Federation
Russian Federation
E. V. Shutov
Кафедра нефрологии и гемодиализа, кафедра биохимии Российской медицинской академии последипломного образования МЗ РФ; Московская городская больница им. С.П. Боткина
Russian Federation
Russian Federation
E. S. Grabskaya
Кафедра нефрологии и гемодиализа, кафедра биохимии Российской медицинской академии последипломного образования МЗ РФ; Московская городская больница им. С.П. Боткина
Russian Federation
Russian Federation
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Review
For citations:
Ermolenko V.M., Yarovaya G.A., Shutov E.V., Grabskaya E.S. Lipid abnormalities in patients on continuous ambulatory peritoneal dialysis. Nephrology and Dialysis. 2002;4(2):118-120. (In Russ.)
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