Clinico-morphological characteristics of focal segmental glomerulosclerosis/hyalinosis
Abstract
Clinico-morphological characteristic of idiopathic focal segmental glomerulosclerosis/hyalinosis (FSGH) was investigated by histological, immunohystochemical and electron microscopy methods. Two stage of FSGH were devided. The first stage characterized by the predominantly lesion of juxtamedullar glomeruli with mild fibroplastic transformation (FT). Tubulointerstitial component (TC) was weakly expressed or absent. 53,2% cases were immunonegative, in 21,8% fixation IgM was detected. Activity index (AI) was 1,6 ± 0,6, sclerosis index (IS) - 3,7 ± 0,8. In 71,4% cases nephrotic syndrome was present. Second stage of FSGH was characterized by the lesion of juxtomedullar as well as medullar with high intensity of FT and TC. Immunonegative were only 7,7% of cases, fixation of IgM revealed in 73,1%. AI was 3,3 ± 0,8; IS - 10,6 ± 2,2. The nephrotic syndrome (34,3%), hypertonic (21,8%) and mixed form (34,3%) were detected. Decrease of glomerular filtration rate and concentrative function of kidney was found.
About the Authors
B. R. Djanaliev
Кафедра патологической анатомии ММА имени И.М. Сеченова
Russian Federation
Russian Federation
V. A. Varshavsky
Кафедра патологической анатомии ММА имени И.М. Сеченова
Russian Federation
Russian Federation
E. P. Proskurneva
Кафедра патологической анатомии ММА имени И.М. Сеченова
Russian Federation
Russian Federation
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Review
For citations:
Djanaliev B.R., Varshavsky V.A., Proskurneva E.P. Clinico-morphological characteristics of focal segmental glomerulosclerosis/hyalinosis. Nephrology and Dialysis. 2002;4(1):33-38. (In Russ.)
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