Low molecular weight heparin-fragmin in treatment of children with nephrotic syndrome
Abstract
There is no consensus on the optimal therapeutic and prophylactic approach for thrombotic complications in nephrotic syndrome, so the investigation was performed to evaluate the efficacy and safety of low molecular weight heparin-fragmin in nephrotic children. Fragmin was given in prophylactic dose (2500-5000 ME/24 h once a day) for 3 weeks with measurement of anti Хa activity. There was no evidence of bleeding and/or thrombocytopenia at the time of treatment. In all patients fibrinogen level decreased after fragmin treatment. Prothrombin complex was in normal limits even if respiratory infection was developed with increasing of disease activity. This study demonstrates the efficacy and safety of fragmin in therapy of nephrotic syndrom in children in above-mentioned dose.
About the Authors
T. S. Voznesenskya
НИИ педиатрии НЦЗД РАМН
Russian Federation
Russian Federation
A. G. Ziabkina
НИИ педиатрии НЦЗД РАМН
Russian Federation
Russian Federation
T. V. Sergeeva
НИИ педиатрии НЦЗД РАМН
Russian Federation
Russian Federation
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Review
For citations:
Voznesenskya T.S., Ziabkina A.G., Sergeeva T.V. Low molecular weight heparin-fragmin in treatment of children with nephrotic syndrome. Nephrology and Dialysis. 2002;4(1):38-40. (In Russ.)
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