The role of the etiology and other factors in the progression of chronic renal insufficiency
Abstract
The aim of this study is to determine the effects of the primary kidney disease and others factors including age and sex on the onset and progression rate of chronic renal insufficiency (CRI) as well as on the survival rate of hemodialysis patients. 1559 patients with CRI were observed. The age of 60% of them was 20-50 years. The primary kidney disease in 30,6% of patents was glomerulonephritis (GN), in 14,8% - pyelonephritis. In 15,5% of cases the primary kidney disease was unknown. 629 patients were treated with hemodialysis. The correlation between both the onset and progression rate of CRI and primary disease was found. The highest speed of progression was observed in patients with GN and it was the lowest in patients with policystic kidney disease. The CRI developed earlier in patients with nephritic and mixed type of GN when compared to patients with hypertonic and latent types of GN. The age, sex, urinary infections, surgical interventions and associated diseases were the major factors that affected survival of the patients. The life expectancy correlated directly with glomerular filtration and urinary sodium excretion and inversely to serum urea and creatinin level, as well as blood pressure. 5-year survival rate of hemodialysis patients was 82% in the group with pyelonephritis, 73% - in the group with glomerulonephritis, 63% - in the group with amyloidosis, 61% - in the group with hypertensive nephrosclerosis. 59% of hemodialysis patients with pyelonephritis and 40% with glomerulonephritis survived for 10 years. 5-year survival rate of young hemodialysis patients (below 50 years) was 82%, and 10-year survival rate in this group of patients was 50%. 5-year survival rate in the older group of hemodialysis patients (above 50 years) was 50%, their 10-year survival rate turned to be equal 6%. The ratio of male to female in the beginning of the hemodialysis treatment was 61:39, after 5 and 10 years of hemodialysis it was 63:37 and 66:34 respectevely.
About the Author
R. A. Aliev
Уронефрологическое отделение Турецко-американского медицинского центра, г. Баку
Russian Federation
Russian Federation
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For citations:
Aliev R.A. The role of the etiology and other factors in the progression of chronic renal insufficiency. Nephrology and Dialysis. 2001;3(3):358-364. (In Russ.)
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