Toxic Metals: Mechanisms Of Nefrotoxicity
Abstract
Kidney is the «target» organ for xenobiotics especially for toxic metals. Citotoxicity of these metals is caused by three interacting mechanisms: intensification of lipids peroxidation; depression of oxidative phosphorylation in mitochondrias; pathology of calcium homeostasis. Correspondingly, therapy with antioxidants, membrane stabilisers, drugs affecting function of mitochondrias and blocators of calcium channels should be included in prophylactics and pathogenetic therapy of chronic xenobiotic poisoning.
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For citations:
Aksionova M.E. Toxic Metals: Mechanisms Of Nefrotoxicity. Nephrology and Dialysis. 2000;2(1-2):39-43. (In Russ.)
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